Mods / Disease

• RRise of the Xenomorphsby Eremus007After the events in Alien: Resurrection, the ship carrying the aliens crashed in the forests of the United States of America, and as it crashed, it took the Aliens with it, and so the planet was safe. At least, that’s what we were made to believe. One Royal Facehugger survived the crash, and is n...134.1k downloadsupdated 10 y ago
• AA Demon Awakensby R34LM(2024 Update- It has been brought to my attention that this scenario no longer works on the latest builds of the game. Unfortunately, I no longer possess the files to rebuild the scenario and, to be honest, my interest in doing so is simply not there, especially considering that, from what I can...130.9k downloadsupdated 12 y ago
• LLycanthropyby ArcticRazorMyths and legends from hundreds of different cultures tell stories of people becoming ravenous nocturnal beasts. Most of these beliefs have been attributed to curses or spiritual power... but not anymore.80.9k downloadsupdated 15 mo ago
• [[Outdated] Cult of Cthulhuby Morrolan! - I've been told this mod no longer works, users beware - ! "Ph'nglui mglw'nafh Cthulhu R'lyeh wgah'nagl fhtagn" - In his house at R'lyeh, dead Cthulhu waits, dreaming. Will the cult of Cthulhu be able to awaken the great old one, or will they be rooted out?70.8k downloadsupdated 12 y ago
• NNecromorphsby Wilfredo PaulinoAn extraterrestrial plague, which forms deceased bodies into nightmarish alien-zombie-mutants and is caused by Marker artifacts. (Dead Space) Update: New Necromorphs, abilities and events have been added.67.6k downloadsupdated 12 y ago
• AAnti-plagueby Белый КотAfter watching enough simulations about how easily humanity can be destoyed by different plagues, people all over the world decided to make a special computer program to analize pandemic situation and do what is necessary. it was actually a very good decition, because quite soon after that a grou...65.6k downloadsupdated 11 y ago
• BBeyond Humanby indigofenixSummary: Guide a benevolent gene-manipulating virus in its campaign to bring about the next stage in human evolution in this heavily event-driven scenario. Many options and playstyles, with over 10 different endings - what will humanity's future hold? Long version: A genetic engineer, seeking to...58.6k downloadsupdated 8 y ago
• AAfter The Plagueby brothercakeNobody knows how the plague started, but we all know how it ended. How it deciminated whole continents before killing all its hosts. Now the world is in total anarchy, there's no global travel, and only remote populations survive in large numbers. |-o-| You must take control, establish order and...57.6k downloadsupdated 12 y ago
• CClockwork Virusby ExeterAs a strange unclassifiable virus the likes of which mankind has never seen before, infect humanity and kill them through a series of horrific flesh-to-metal transformations. Based on the 'Clockwork Virus' from the SCP Foundation Wiki.56.1k downloadsupdated 3 y ago
• 膜膜蛤必被续by BlackCat我就讲中国有一句话叫“闷声发大财”。我什么话也不说，这是最好的。但是我想我见到你们这样热情啊，一句话不说也不好。所以刚才你一定要，在宣传上将来如果你们报道上有偏差，你们要负责。52.2k downloadsupdated 11 y ago
• TThe Mercer Virusby Canton"Humanity is stagnant. Dying. I would give it one body. One mind. Think about it -- no more conflict. No more disease. No more suffering. Don't you see? I'm giving it a second chance." -Alex Mercer Where he failed, you will succeed.47.0k downloadsupdated 11 y ago
• TThe Last Of Usby Blastoise914Ophiocordyceps unilateralis has mutated so that it can infect humans. The Cordyceps fungus causes a unique brain infection that exhibits parasitic qualities. As a result, the host's body is taken over by the pathogen. Can you infect the world and spread the Cordyceps fungus to all living beings?45.3k downloadsupdated 11 y ago
• NNeurax Worm: Aftermathby knightfluttershyThe Neurax Worm has enslaved humanity! The World now worships it as their god and master...but there is still hope. Somewhere in the world, a virus breaks out. A virus that seems harmless to humans...but is very lethal to a certain mind controlling parasite. Be careful-the world still worships th...44.2k downloadsupdated 11 y ago
• DDarknet Computer Virusby SUNSET CODAWe live in a very unstable world today. One single deadly computer virus could wipe out all the technology and automated services we have, and that's exactly what this scenario explores. Two college students create a virus that will fish information from any computer it infects, and can be sent a...43.2k downloadsupdated 12 y ago
• 冠冠状病毒by 啊！雪莉！2003年SARS疫情已经过去，然而时间已经过去17年，2020新的冠状病毒变种出现在世界上，现在已经有疫苗和先进的医疗设备来治疗这种疾病，而这种病毒和SARS有一定的相似性，这难道是人类的末日么？41.3k downloadsupdated 12 y ago
• SSCP-751 (Organ Eater)by Eremus007SCP Documentation number 751 Item: SCP-751 Object class: Euclid Agent, there has been a containment breach at site C-751. A very dangerous parasite known to us as SCP-751 has escaped due to the unprofessional care of Dr.---------- and his co-workers. One of our interns, Dr. Alexander Fredricks, h...41.0k downloadsupdated 8 y ago
• RResident evilby Lil nuggetAfter seeing no decent Resident evil scenarios, I decied to make my own. I hope it lives up to your standards. The symptoms are based heavily on the T-virus. All feedback and constructive criticism is accepted. Note:This scenario might be too easy for some players. This my first time using the sc...36.9k downloadsupdated 8 y ago
• TThe Thingby JahtzeeThe Thing V1.3 A team of Canadian scientists has discovered the frozen remains of a crashed spacecraft in Greenland. Although they don't know it yet, the alien body found within is still very much alive... 'The Thing' is a parasitic extraterrestrial lifeform that is able to assimilate other organ...36.7k downloadsupdated 12 y ago
• SSCP-632 (A Bad Headache)by infernalthingSCP-632 is an Euclid classed SCP which is a spider species that release their millions of microscopic eggs attached to thin web strands carried away by wind. The larvae enter through human skin pores and travel to the brain causing headaches. They release endorphine when pressure is applied makin...34.9k downloadsupdated 12 y ago
• PPlants Vs. Zombies Ultimateby 76561198836208876A while back I searched the Plague Inc. custom scenarios to see if there were any good PVZ scenarios and I didn't find any. That is why I made this, to fill a hole in my heart and BRAINSSS. Dr. Zomboss (formerly called Carl) was tired of working his dead-end job as an unpaid intern and having no...33.8k downloadsupdated 3 y ago
• NNature's Revengeby Jack of HeartsIn attempts to restore the Earth to its natural form the government has secretly created an artificial virus that alters a person's ideas and actions to be more eco-friendly. However, one forgotten line of code has significantly changed its purpose.32.9k downloadsupdated 12 y ago
• 阻阻止高考！by 765611984520949972079年，中国的教育模式由于其高效性已经普及世界，高考作为其最终检测方式已经将全体人类的思维僵化，你能打破这一现状吗？（版本更新次数：2）32.2k downloadsupdated 7 y ago
• SSemi-Realistic Zombie Plagueby anitachallRealism for the win! I tried my best to science the shit out of this. Dont forget to explore symptom and ability trees, i tried to make each kinda worth while. Note: This is still kinda WIP30.5k downloadsupdated 11 y ago
• RRabiesby SMG Guy *Ask me to throw guns*While technology is rapidly developing, humans have already forgotten many infectrous diseases. However, due to the quick decrease of forest area, animals in South East Asia, already infected by Rabies, started to attack humans. Although there is Rabies vaccine to cure it, the death percentage is...25.2k downloadsupdated 12 y ago
• CCOVID-19 Coronavirus Outbreakby Fenix酱In December 2019, a new strain of coronavirus, termed COVID-19 (2019-nCoV), emerged in Wuhan, China and spread globally. To date, 378,679 has been infected and over 3,000 lost their life (JHU coronavirus resource center). This scenario was created for raising our awareness to the coronavirus, and...25.0k downloadsupdated 7 y ago
• SSCP-610by FoxySezRawrSCP-610 is a contagious disease that affects the victim's skin, making them grow large amounts of infectious scar tissue and eventually causing death. Once fully infected, the disease turns the victim into a creature actively seeking out new people to infect or staying put and transforming their...24.3k downloadsupdated 12 y ago
• 貮貮刺螈by 羽落鸽在这个貮刺螈快速潜入生活的世界里，人类将何去何从？23.8k downloadsupdated 11 y ago
• TTrump's Awakeningby LatverionThe multi-billionaire magnate Donald Trump has decided to run for the presidency of the United States of America, the most powerful country in the world (At least until 2017). We're screwed. _______ I actually have put effort on this scenario (Unlike some other Trump scenarios). I'll keep updatin...23.7k downloadsupdated 11 y ago
• CComputer Virusby pipolwes000As a sentient computer virus, infect and takeover the world's computers, and kill all humans.22.9k downloadsupdated 12 y ago
• BBacteria: Google Translatedby 76561199016102431Bacteria plague but most stuff is google translated 150 times.22.9k downloadsupdated 13 mo ago
• MMonster Girl Diseaseby bransonA strange, magical virus has appeared. It enters humans and changes their DNA, transforming their bodies into monster girls! Unlock new monster girl types to help spread the plague!22.3k downloadsupdated 9 y ago
• PPhoenix Virusby RazeSynopsis: Scientists in Japan have found a virus frozen in ice in the middle of somewhere... Upon further analysis, this virus appears to able to emit its own bio-electricity. With some research, they've come to the conclusion that this virus can be used to further their 'immortality' project wit...22.2k downloadsupdated 10 y ago
• 为为sbeam献上钱包by NotherDecade【摸了】sbeam已经风靡全球，而你，作为一名优秀的sbeamer，让全人类都屈服于G胖的淫威吧！ If you don't know, “sbeam” is a joke(meme) about “steam” in China. This is a local name, “sbeam” is equal to “steam”. I'm sorry I can't make an English version(or any language other than Chinese). Because it is based on the Chinese network popular lan...22.1k downloadsupdated 10 y ago
• AAlien Hive Mindby TrivorowowowowowoYou are an alien parasite, which crash landed on earth. Your goal: upgrade these puny humans, and turn them into a partial hive mind ready for interstellar travel. ----------------------------------------------- Features! *Questionable scientific terminology *Alien Parasites *Weird stuff *Stuff t...21.7k downloadsupdated 9 y ago
• DDon't let the Bugs biteby Eremus007He looked up to the sky, wondering if we were the only ones in the universe. He closed the curtains and went to bed. If he would have gazed for another minute, he would have seen a green shooting star. Would he have wished he knew about alien lifeforms? Meanwhile, that shooting star wasn't an ord...21.4k downloadsupdated 11 y ago
• 吸吸血鬼异变（东方project）by North13537（中文描述在下面）In this modern society,there is no youkai’s paradise.In order to reinvigorate the scarlet family,Remilia·Scarlet has to fight against the whole human society on her own. Although Remilia still can’t create new vampire,this time she has some unique ability of devil——scarlet pact,which can...21.2k downloadsupdated 9 y ago
• NNazi Zombiesby Bilbo Of SmashingtonI have recently developed an updated version of this scenario that, while largely simmilar to this one, fixes a lot of the balancing problems with this version. Find it named 'Nazi Zombies 2.0' if you're interested. Based off CoD zombies, from Treyarch, use this plague to wipe out humanity as the...20.7k downloadsupdated 11 y ago
• FFan Girl Epidemicby Kitsumi03Fan girls start in small numbers but as celebrities gain popularity, fan girls grow in numbers. Can you create a worldwide fan girl epidemic?20.6k downloadsupdated 11 y ago
• MM.A.t.H.by Mega MunchyOne of the most head-hurting school subjects become mankinds deadliest disease, MATH!!! Infect the world & kill it off with numbers, symbols, equations, & many more. Can humanity outsmart Math?20.6k downloadsupdated 11 y ago
• PPokémon Goby TitanKämpferThe newest mobile app Pokémon Go goes viral... But is it already enough to kill humanity? Kill the humanity with this simple app, before the goverments can ban it world wide! Notice: I'VE GOTTEN SO MUCH POSITIVE REVIEWS AND COMMENTS! BUT PLEASE, DO NOT SEND ME A FRIEND INVITATION - I'M ONLY ACCEP...20.2k downloadsupdated 10 y ago
• AAmong Us Transformationby ALL-CONSUMING VOIDThank you so much for the feature, NDEMIC! It's a plague that turns you into an Among Us character. All countries have been renamed alongside all symptoms. If anything's in all lowercase that's the editor being weird, not me20.2k downloadsupdated 5 y ago
• ☣☣ Jacksepticeye Virus ☣by AngelboyVRWellcome to the ☣ Jacksepticeye Virus ☣ scenario by xXAngelboyXx Changelog: >>> Added new traits updated grammar and added 4 eastereggs into the trait sections, have fun finding them ;) Once there was a Youtuber with the idea to take over the world and call it Bossatronia. he started with the fir...20.0k downloadsupdated 11 y ago
• TThe Ebola Virusby Chimax83Ebola was a very feared virus in 2014. It could only be spread by blood and contact with bodily fluids of someone who was infected. A cure was developed soon after that. Now, a new strain of the virus exists, shielding it from the previous cures made. Can you be the one to end the world with the...19.9k downloadsupdated 11 y ago
• CCult Simulatorby DeDevilTailsSo-called 'new religious movements' are a strange thing. They spread much like an infectious disease does, and can be just as detrimental to society at large. This scenario is about making your very own cult and bringing the entire world under its control. This is a very in-depth scenario so don'...19.6k downloadsupdated 8 y ago
• NNano machinesby MushyYou're an AI made up from nano machines. You can choose to help humans or destroy them, but will they accept you or will they keep trying to destroy you? Will you choose to be safe and destroy them before they overwrite you or will you help them and trust everything will be fine? Pay attention to...19.0k downloadsupdated 9 y ago
• DDragon's rebirthby EtheruryuMake reborn dragons ? It is now possible, thanks to a prion infectivity reptiles and has mutagenic properties that allow it to fasconner DNA of its host at will. The time has come for the dragons to wake up !19.0k downloadsupdated 12 y ago
• TTerraria corruptionby MrCompInspired by the game Terraria. Description: For some odd reason, the corruption from Terraria became reality and started spreading on plants in our real world. It needs to adapt to survive. What will happen if it infects humans? Features & gameplay: This scenario has many custom events, news arti...18.8k downloadsupdated 10 y ago
• NNecroax Wormby neilb67You are not a Necroa Virus, nor a Neurax Worm, you are the Necroax Worm, controlling infected's brains and reanimating the dead, and controlling the zombies brains too! Undiscovered for thousands of years, humans have given it the meaning to spread. Can you destroy all of mankind?18.5k downloadsupdated 4 y ago

165 disease mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.