Mods / Active Items

• DD666by micromarioDescription: Reroll your soul Itempools: Treasure and devil Effects: (Active) If you have red health, the item takes two hearts away and gives you a random devil deal item If you have soul health, the item takes three hearts away and gives you a random devil deal item If you don't have health, th...4.3k downloadsupdated 10 y ago
• [[REP+] Always Restockby 76561199164471930Now there is always a restock machine in the shop This mod ensures that you will always find a restock machine in shops, both in normal mode and in Greed Mode. The restock machine is automatically generated in all shops and adapts by adjusting its position when you play as the Tainted Keeper.4.3k downloadsupdated 9 mo ago
• SShratty!by 76561199045035657Meet UPDATED FATTY! Now in the basement, instead of the usual Fatty and some versions of it, we have ogres! Plus, Donkey also found a month instead of a Pony, and now there is a lot more noise in the basement due to chatter. You'll have to deal with it) Hope you enjoy playing with it. <34.2k downloadsupdated 4 y ago
• OOxygen Not Includedby Aks ♐Combining the worlds of The binding of Isaac and Oxygen not included, This mod introduces a new character, the Duplicant, and other nifty items coming from the oxygen not included universe! Current features~ ~~~~~~~~~~~~~~~ New character: Duplicant Damage: -1 Speed: -0.3 HP: 3 ~~~~~~~~~~~~~~~ New...4.2k downloadsupdated 10 y ago
• MMystery Gift (BOOSTER PACK #1)by StripedUPDATE: This mod was released officially as a part of March 2017's booster pack! No need to download anymore, but will leave this mod page up regardless. A fun little gift box active item just in time to be late for Christmas! When opened, spawns a random item from the current room's item pool! B...4.2k downloadsupdated 10 y ago
• TTerraria teksturaby AsukaМод меняет предметы Айзека на предметы террарии The mod changes Isaac's items to terraria items The mod changes 176 items Over 56 familiars Over 240 costumes (from over 50 different items) 6 transformations Keys, bombs, coins All hearts 15 trinket Redrawn all tarot cards and inverted tarot cards...4.2k downloadsupdated 3 y ago
• IItems Reforged [Afterbirth+]by KaliItems Reforged! This mod aims to rebalance and tweak items that would otherwise be detrimental to a run, while remaining faithful to the vanilla experience. Supports External Item Descriptions! Supports Mod Config Menu! Supports Revelations! Supports Fiend Folio! & More! All changes are configura...4.2k downloadsupdated 6 y ago
• SSyringes! A New Consumable [Afterbirth+ Only]by AgentCuccoA brand new type of consumable! - Syringes behave similar to pills, they give temporary buffs or debuffs to the players, and they are undiscovered until used for the first time. - At the beginning of a run, a pool of 13 random syringes is determined for the rest of the run. - Syringes have a 33%...4.1k downloadsupdated 6 y ago
• DDogma Clickerby Phno 🐙"Having trouble with your TV? Just switch the bloody channel. Easy as that :v" It should be completely normal and logical that you can defeat an enemy, which comes out of the tv, instantly if you just turn off the tv. Right? Right. So, now this is possible with the clicker. The clicker remains it...4.1k downloadsupdated 3 y ago
• BBox Cutterby nickBOX CUTTER Let your soul escape Type: Active Cooldown: None Effect: Take one red heart damage and spawn a half soul heart. Pools: Shop, Secret, Curse An activated item, Box Cutter has no cooldown. Instead, it uses your life as a resource. Every time you activate Box Cutter, it will deal you a red...4.1k downloadsupdated 10 y ago
• LL4D2 Hunter Larynx [FIXED]by 76561198326237573Now you can really hear his pain. "At last, sheer auditory annihilation. Scream with the familiar unhinged rage of the Hunter from Left 4 Dead 2 whenever you use the larynx and watch all your unsightly enemies instantly dissipate into a fine red mist." Different levels of charge use different voi...4.1k downloadsupdated 3 y ago
• DDon Quixote Limbus Company as Death Card and Necronomiconby 76561198381080953Changes the Necronomicon and Death Card (and also Black Hearts) sound effect into Don Quixote from Limbus Company screaming "Limbus Company". This truly was our Limbus Company (the antibirth music mod i used in the video -4.1k downloadsupdated 2 y ago
• OOneShot - Niko (Afterbirth+)by DarkLowRepentance version made by Umbreon DC Niko from OneShot joins the disaster! Included: • Character - Niko Niko from OneShot! Has 1 heart and 2 soul hearts Starts with Messiah's Lightbulb More Speed and Luck Less Damage and Range/Tear Speed • Activated Collectible - Lightbulb (Messiah's Lightbulb)...4.1k downloadsupdated 8 y ago
• [[REP] Characters Only!!!! The Binding of Pokemon Legendsby 76561198429240276This mod only contains the characters from The Binding of Pokemon Legends. To play the full version of the mod go to the following link :) Credits and support to the original authors of the mod: The Binding of Pokemon (Afterbirth+) Mod by Thor Maan de Kok. The Binding of Legends (Rebirth) by Spin...4.0k downloadsupdated 3 y ago
• FFiend Folio [RUS]by Dick NukemFiend Folio Изменения внесены только в части переведенных строк для мода EID (External Item Descriptions) Как установить: 1. Скачать все другие необходимые моды, а именно: Fiend Folio: Reheated - 500 New Monsters! Custom Stage API External Item Descriptions - настроить на русский язык 2. Установи...4.0k downloadsupdated 3 y ago
• TTantrumby ☢ Nato Potato ☢Tantrum is a 6 room charge active item that deals 30 damage to every enemy in the room, gives them the fear effect for 10 seconds and boosts your stats by 20% for 10 seconds. It can be found in curse rooms, secret rooms and rarely in red chests. Idea and sprite by aalqui. This is included in POTA...4.0k downloadsupdated 7 y ago
• OONESHOTby 76561198880252580This mod features 2 new characters, Niko and The World Machine both of them have exclusive to them active and passive items Alongside with that, this mod adds 10 new oneshot themed items (hopefully) more characters & items soon! We also made a custom menu! It features a custom intro, custom ui fo...3.9k downloadsupdated 3 mo ago
• MMama Mega Greed Mode Buffby kittenchillyMakes Mama Mega explode after every wave in Greed Mode! This gives the item a significant buff and more of a practical use in Greed Mode.3.9k downloadsupdated 5 y ago
• AAwfulTweaks [RGON]by Mr. HeadcrabThis mod requires Be sure to follow the full install instructions on repentogon.com Are you sick of the standard, well-thought-out challenge mods out there? Have you found yourself wanting a mod made primarily for the enjoyment of anyone watching you play? This might be the mod for you! This mod...3.9k downloadsupdated 4 mo ago
• SStart Item Settingsby minishrek4This mod is based on the "Start Item Options" mod. it adds some settings to change what items spawn, and how many. options include how many items spawn. 0-28 how many items you can take. items that will always spawn. what item pools items are spawning from. min/max quality + more this is a WIP an...3.9k downloadsupdated 13 mo ago
• BBlue Archive Reskinsby 76561199102200098Blue Archive (BA) Resprites for Bethany, Magdalene, and Jacob & Esau! This is a rework of my older mods, I redid the graphics and added a little more to them! I plan on adding more students and other item resprites in the future so please look forward! Current students included-- Koharu , Momoi &...3.9k downloadsupdated 2 y ago
• LLight's Items 2by LightFrogLight's Items: Pack 2 Light's Items Pack 2 adds five new and unique items to The Binding Of Isaac: Afterbirth+. The Items: Torn Blanket 'Spooky' Passive Item Adds a chance for slain enemies to become ghosts, fighting for you for the current room. Found in boss rooms. Egg Timer 'Hard Boiled' Activ...3.9k downloadsupdated 9 y ago
• GGiga Bombby NeoDementA simple active item that allows the player to drop a Giga Bomb when used. 4 room charge. I made this because after getting 100% in Repentance, I realised I'd never had a Giga Bomb in my inventory at any point. So I felt like a more common way to acquire them would be good. UPDATE 07/07/2021 Giga...3.9k downloadsupdated 5 y ago
• Ffreaky dudes instead of effectsby 76561199016204414changes the giantbook popup of the following items to very freaky and sexy black men: - nencronomicon - monster manual - dead sea scrolls - sun card - book of belial - moms bra - anarchist cookbook - bible - death effect (skull) - Satanic bible - rainbow poop very funny.3.9k downloadsupdated 23 mo ago
• EElegy of Emptinessby damagazThe Elegy of Emptiness is an active item that can be found in Treasure rooms. Using this item grants a statue which is based on one of Isaac's transformations. Each transformation has a different effect: Beelzebub gains a fly statue which creates blue flies, Leviathan gains a demon statue which s...3.8k downloadsupdated 8 y ago
• AAlexelcapo Modby TremensMod de Alexelcapo. Este mod contiene: Nuevo personaje: Alexelcapo 1 Item activo 2 Items pasivos 1 Familiar(Halfonso) 1 Habilidad especial del familiar Sonidos de muerte, daño y uso de item activo. Y muchos de sus memes. Descripción de los items: -Falta daño: Al agarrarlo reduce el daño del person...3.8k downloadsupdated 9 y ago
• WWhistle Piece - Yondu's Arrowby Avid pooper pantI saw a Lazy Mattman video, where he mentioned Yondu from the guardian of the galaxys arrow. So I thought why not try, resulting in my first very simple mod. This mod introduces a new collectible item, "Yondu's Headpiece", an active item that spawns the Yaka arrow next to isaac. By using the item...3.8k downloadsupdated 3 y ago
• PPeppino Larynxby Apollo JusticeFor those like me that have been infatuated with Pizza Tower, I decided to make a mod that changes the Larynx sound effects to the funny Italian man's screams3.8k downloadsupdated 4 y ago
• AAntibirth for AB+ (and Repentance)by im_temDo not install this if you want to play Antibirth, go to antibirth dot com instead Antibirth was made by P.E.N.I.S team, not me or even better, get yourself Repentance instead of running this, dammit! ----- Antiborne is now real, even for Afterbirth+ (now also for Repentance!) Let's be honest, yo...3.8k downloadsupdated 4 y ago
• TTelefraggerby DrakonnasThis mod adds a new item that lets you kill enemies by teleporting into them! Telefragger is an active item that instantly moves you a short distance in the direction you are walking in. If you happen to teleport into an enemy, they die! *Update* Teleporting into a boss does not kill it. Instead,...3.7k downloadsupdated 10 y ago
• BBosses Unleashedby VideoGameNewsEver wanted to unleash the power of a boss onto your foes? Well LOOK NO MORE!!! Bosses Unleashed!!! This mod have over 90 NEW items that can be found in the treasure and shop rooms in both normal or greed mode. Here is the list of all new items. Enjoy! Larry Jr The Hollow Monstro Chub C.H.A.D The...3.7k downloadsupdated 10 y ago
• SSIUUUUUUUU for Larynxby Hideo KojimaSIUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU Requested by: u/hxllxqxxn3.7k downloadsupdated 4 y ago
• RRosaries Over Coinsby 76561198963408565Change "all" coins with rosaries Changed: All coin trinkets All coin pickups All Slot Machines got rosaries instead of coins A Quarte - Rosary Necklace A Dollar - Heavy Rosary Necklace Wooden Nickel - Wooden Rosar (Changed Kipper's HP temporarily removed)3.7k downloadsupdated 8 mo ago
• EExtinguisher of Soulsby SprSnpr_Extinguish Their Souls!!! This is a mod that changes the sprites and sound effects of the Urn of Souls to resemble a fire extinguisher. That's all. Everything related to the Urn of Souls has been updated- except for one thing. Judas and Dark Judas' birthright gives them a unique sprite and effect...3.7k downloadsupdated 3 y ago
• TThe Binding of Pokimon Mystery Dungeon [Afterbith + Edition]by NarxThe Binding Of Pokimon Mystery Dungeon is a mod that turns Isaac's basement into pokemon mystery dungeon world, includes PMD levels, bosses soundtrack sound effects and much more... DOWNLOAD FULL VERSION HERE: mega. nz/file/yhEADZpa#X9R9MN2_tNITsbixkOxlmknccSU1cBjsD5GEUmaVbwI FEATURES: -Playable...3.6k downloadsupdated 6 y ago
• UUnnerfed Item Mimicsby usernamenotavailableUnnerfs Blank Card and Placebo to back to how they used to be before Repentance, meaning all cards and pills take 4 rooms to recharge. Also changes Clear Rune to act like that as well because why not. Note that this will essentially make some of the new runes like Soul of Lilith extremely overpow...3.6k downloadsupdated 5 y ago
• LLazy MattMan (playable character)by 76561198881685834The worm, The myth, The lucky sun of a gun. LazyMattman is here to enjoy the content! But who knows the luck of what may happen next?3.6k downloadsupdated 2 y ago
• CCatalog (now in game as Keeper's Box!)by TremisUPDATE: This item is now functionally in the game as Keeper's Box. Item is now obsolete as a result but I couldn't be happier! Hope everyone enjoys this as a permanent part of Isaac! Item Description: A holiday-themed item that hearkens back to simpler times. It can be found in shops, libraries,...3.6k downloadsupdated 9 y ago
• BBaby Plum to :plumagony:by Mr. HeadcrabChanges Baby Plum to look like the emote :plumagony: Also edits Fruity Plum and Plum Flute and it's sound effect3.5k downloadsupdated 14 mo ago
• DDark Spiny Shellby 76561198368618066Dark Esau decided to take a break on his revenge on Jacob, and is letting the Spiny Shell from Mario kart do all the work instead. Prepare to race against a crazy flying shell, which destiny is to destroy you, at any prize. You can even obtain a second shell with Birthright, if it's not enough! U...3.5k downloadsupdated 5 y ago
• BBetter "Converter" Sprite [No Longer Needed!]by EMORYGlorious leader Edmund McMillen has spoke. The "Converter" is supposed to look like a DC to AC power converter. This notion is ridiculous, since the "Converter" looks more like a blood pressure monitor or a paint bucket with broken handles. This simply tweaks the sprite to better represent what t...3.5k downloadsupdated 9 y ago
• HHomer's Epic Itemsby 76561198448106326A mod that includes Greek mythology themed items and characters. And now it's a semi-manufactures but in future it will have more and more rich content. Including but not limited to new characters,cards,rooms and monsters. This mod is compatible with EID. Wish you can enjoy this mod!3.5k downloadsupdated 3 y ago
• AA Greed's Guideby RubbleType: Active Item Recharge: 6 Rooms Name: A Greed's Guide Description: Everything Money and More! This item can do many things: Spawn: 1 Penny 2 Pennies A nickel A dime, A gold key (or 2) A gold bomb 1-3 Greed Gapers Greed Super Greed A Lucky Penny 1-2 Chests Items: Head of the Keeper, Midas Touc...3.5k downloadsupdated 10 y ago
• JJack in the Boxby EstrogenGirlJack in the Box Mod Design and Art by CatnipOverdose Coding and Trailer by AstroPenguin642 This mod adds an active item to the game called Jack in the Box. It is recommended to play this mod either blind, or after watching the video, as the effects of the item are fun to figure out. Jack in the B...3.4k downloadsupdated 9 y ago
• FFlux Capacitorby MundanePantherFlux Capacitor Active Item When used, teleports the player either back or forward in time to the previous or next floor. Part of the "Back to the Basement" mod pack. A mod collection for The Binding of Isaac - Afterbirth Plus Twitter - @rhysdee Web - www.rhysd.com3.4k downloadsupdated 10 y ago

621 active items mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.