Mods / Pickups

• DDa Rules - A Sandbox Menu Thingy [Rep/Rep+/AB+]by JSGDa Rules is a sandbox-style menu that allows you to mess around with almost anything in the game, from monsters to visual effects. Sure, you can do "Every item is"...BUT you can also replace, resize, push, rotate, at tach, path, animate, change costumes and a LOT more than that. Theres extra effo...483.7k downloadsupdated 4 mo ago
• [[REP- ONLY] Fiend Folio: Reheated - 500 New Monsters!by ErflyFOREWORD This version of the MOD is for Repentance only. However, there is an updated REPENTANCE+ VERSION linked here! Why settle for less items, less monsters, and less characters? More can be found in Fiend Folio: RELOADED! Check it out! Fiend Folio MOD is back in town baby! The original MOD ha...411.2k downloadsupdated 3 mo ago
• RReactionAPIby 76561199214964579ReactionAPI NOTE: This mod is an API. It has no visible impact on the game, and should only be enables when required by another mod. An API that greatly eases the creation of 'Reaction to Quality Items' Mods. This mod represents the brain of those mods, the part that scans the room for items and...290.7k downloadsupdated 23 mo ago
• [[Rep] The Binding of Isaac: Epiphanyby 76561199520140339The Binding of Isaac: Epiphany: Wave 7: The Binding of Isaac: Epiphany is a mod that aims to add a new variant for all characters in Repentance, called "Tarnished" characters. We have 9/17 characters completed so far, and 1 new character is being added per wave. Each of these characters have a fu...265.0k downloadsupdated 7 mo ago
• RReaction Port Packby 76561199214964579This pack depends on ReactionAPI in order to function, and cannot display reactions on it's own. Be sure to enable both! Reaction Port Pack is a package of well-known Reaction to Quality Items mods, but the quality detection system is powered by ReactionAPI, which improves on some issues found wi...258.2k downloadsupdated 16 mo ago
• IItems Drop on Death - Animationby 76561198986749186This mod adds an animation when the player dies, dropping their items on the ground. It is only visual and no pickups actually drop! It also doesn't change or add any sound effects, and does not modify the actual player animation. It simply adds the item drop animation on top of player death anim...232.3k downloadsupdated 2 mo ago
• LLuckier Penniesby AtaristicMakes lucky pennies more visible.221.8k downloadsupdated 6 y ago
• RReverie - Touhou Combinationsby CuerzorReverie is a content mod inspired by Touhou Project series, with a large amount of items and characters with unique effects! 200+ new items and trinkets 3 new characters and their tainted version...or you may find someone else? 7 new alt-floor bosses 2 new secret bosses 9 new consumables A new en...172.6k downloadsupdated 14 mo ago
• VVery Haunted Chestsby AtaristicMakes haunted chests more visible and crusty.151.6k downloadsupdated 6 y ago
• LLazy MattPack [RGON]by Mr. HeadcrabThis mod requires Be sure to follow the full install instructions on repentogon․com This pack contains all* the items commissioned by Lazy Mattman! Many of these items are unique Quality 5s, items that won't appear naturally unless certain conditions are fulfilled *D-Section is uploaded as a stan...148.2k downloadsupdated 7 mo ago
• CCat Coin | Reskin for coinsby banziReplaces all coin sprites with funny cat! Compatible with 'Specialist Dance for Good Items' mod! Compatible with 'Mod Config Menu - Impure' mod! Volume sliders now implemented! Dime dance music credit: Specialist Dance for Good Items - Mod Config Menu - Impure -147.6k downloadsupdated 2 mo ago
• AAlphabirth Pack 2: All That Is Unholyby FacemanFoothandThe Binding of Isaac Alphabirth: All That Is Unholy is the second official modpack from Team Alpha! This pack adds: > 29 new items! > 11 enemy variants! > 2 new transformations! > 1 new character! (Be weary of Black Hearts!) > 4 new runes! > and 4 new challenges that unlock content upon completio...142.9k downloadsupdated 9 y ago
• AAlphabirth Pack 1: Mom's Closetby DeadInfinityThe Binding of Isaac Alphabirth: Mom's Closet is the first of many packs to be developed by TeamAlpha! Download the complete Alphabirth collection here: This one in particular adds: > 31 new items! (including 3 unlockables) > 2 new trinkets! > 1 enemy variant! > 1 new transformation! > 1 new pick...142.4k downloadsupdated 9 y ago
• TThe Sheriff (+Tainted)by catinsuranceGet the remaster of this mod with new content, reworks, and fixes, by clicking HERE! The Sheriff is a new gunslinger character with a revolver and no time for tears. Discover 30+ unique synergies, some of which granting unique guns and abilities! Ammo and bullets The Sheriff has 6 maximum ammo in...131.6k downloadsupdated 19 mo ago
• [[RGON] Repentance Plus!by Mr. SeemsGoodThis mod requires REPENTOGON to operate, for optimization and modding convenience purposes. More Unlocks to Spice Up Your Game! Repentance Plus is a mod that adds: 59 new items; 23 new trinkets; 41 new cards; 6 new pills; 17 new heart pickups; 4 new chest variants; and a bit more? into the game!...129.3k downloadsupdated 9 mo ago
• GGiant Props!by Mr. SeemsGoodPLEASE READ BEFORE COMMENTING THE ONLY WAY TO CONFIGURE THE MOD IS TO USE THE EXTERNAL PROGRAM CALLED BASEMENT RENOVATOR. IF YOU WANT TO INCREASE SPAWN RATES OF MODDED ENTITIES, YOU NEED TO EDIT ROOM WEIGHTS WITH THIS PROGRAM AND IMPORT A NEW .STB FILE INTO THE MOD FOLDER. THERE IS NO OTHER, EASI...129.0k downloadsupdated 15 mo ago
• NNemesisby SinstharNemesis is a new playable character, with her own shooting style ! She works almost like Lilith : she can't shoot, her familiar (some sort of flying mixture) shooting for her. All the items that normally change your tears are now useless ; you must loot Holy Flasks to modify the tears you shoot....111.7k downloadsupdated 5 y ago
• 三三只熊中文控制台/Szx Chinese Consoleby Kev.SunThe whole mod description in English or in Chinese locates in the discussion forum due to the line limit here. The whole mod description in English or in Chinese locates in the discussion forum due to the line limit here. The whole mod description in English or in Chinese locates in the discussio...106.9k downloadsupdated 14 mo ago
• VVisible Cards Reduxby Zombieseatflesh7This is a complete rewrite of kas333's Visible Cards on the Floor Description Have you ever wanted an easier way to identify cards without having to pick them up? This mod gives every card a unique sprite when it is on the ground, so you can easily tell them apart. Changes From Original By defaul...106.2k downloadsupdated 4 mo ago
• DDeliveranceby BaicherraNo, this mod doesn’t add any new floors, huge bosses(?) or anything like that. We’ve put some cute monsters and items which we'd like to see in the game! In general, Deliverance adds: 44 new items! 8 trinkets, 4 cards, new heart and a new pill! 30+ new enemies! 900+ new rooms! Secrets! Mod Suppor...99.9k downloadsupdated 11 mo ago
• AAlphabirth Pack 3: The End Timesby FacemanFoothandThe Binding of Isaac Alphabirth: The End Times is the third official modpack from Team Alpha! This pack adds: > 20 new items! > 7 new enemies! > 2 new pickups! > and 1 new challenge that unlock content upon completion! This mod requires AlphaAPI to play: We highly recommend you play with all of o...99.7k downloadsupdated 9 y ago
• UUnique Coinsby krameraadImproves shading and changes coins to look more like real US coins, and more different from eachother. • Pennies: copper colored • Nickels: larger diameter than pennies • Dimes: smaller diameter than pennies Double pennies are no longer two pennies copy-pasted next to eachother and have a unique...96.2k downloadsupdated 4 y ago
• GGodmode Unleashed [AB+]by MINDS3TFor the Repentance version, GO HERE! Current features: 29 Items! 7 Bosses! 7 New Floors! 2 New Pickups 1 New Pill! 20 New Enemies! 5 New Characters! 1 New Challenge! Revamped special items system! Wait, what did you do to special items?? Don't worry, I made quite a few more items categorized as s...95.3k downloadsupdated 2 y ago
• NNo Health Capby ☢ Nato Potato ☢Want to have more than 12 hearts? The 'No Health Cap' mod lets you do just that! This mod has its own simulated health bar which it displays below your regular one, it kicks into action once you have more than 11 hearts total and starts recording your pickups and damage to make it so your health...92.6k downloadsupdated 9 mo ago
• BBetter Lucky Penniesby 76561198395761104More visible lucky pennies.91.2k downloadsupdated 5 y ago
• Ttoday i will kaboomby Xtrikethis mod replaces the giga bombs with the "today i will/clueless" meme90.7k downloadsupdated 3 y ago
• EExternal Item Description: Alphabirthby PatatifiqueThis mod adds descriptions to Alphabirth Items and makes your life easier. Are you tired of having to go to the Alphabirth wiki everytime you find one of those new items ? Then this mod is made for you ! Enjoy the Aplhabirth mod with clear descriptions for EVERY ITEMS. Alphabirth External Item De...88.3k downloadsupdated 9 y ago
• JJoJo's Kira and DIOby [TBG] Alvys14BlackWith this mod you can play as DIO from Jojo's Bizarre Adventure: Stardust Crusaders! DIO will start throwing knives and with the item THE WORLD. This item will stop time for 3s as DIO was able at the start and will summon his stand for 10s. DIO as vampire has also recovery life powers when he kil...87.0k downloadsupdated 6 y ago
• IInstant Restartby 76561198335323471Reset on R is a small and lightweight mod that lets you instantly restart your run by pressing the R key, without going back to the main menu. 🔁 Perfect for speedrunners, item rerolls, or quickly resetting for a better run. 🛠 Compatibility: ✅ Compatible with The Binding of Isaac: Repentance ✅ Upd...83.3k downloadsupdated 18 mo ago
• NNo Pickup Capby ☢ Nato Potato ☢Want to have more than 99 coins/keys/bombs? The 'No Pickup Cap' mod lets you do just that! This counterpart to the 'No Health Cap mod' keeps track of your coins, bombs and keys and lets you store as many as you want! Like the 'No Health Cap' mod you can use the Mod Config Menu or the console to s...80.4k downloadsupdated 4 mo ago
• RRetribution: 190 Itemsby XalumWarning The Repentance+ DLC broke the modding api in a whole load of different ways, there is no guarentee of compatibility between this mod and the Repentance+ DLC until these issues have been fixed. If you play with Retribution while using Repentance+ you do so at your own risk and should expec...80.4k downloadsupdated 3 y ago
• EEevee: Reunited - Character Demoby BennyStatus Update from Benny The mod has, unfortunately, been cancelled for the foreeable future. There has been a lot of work put into the mod since the demo's last update, but due to mental health issues, I cannot comfortably continue development. Having a second coder on the team or me returning t...80.0k downloadsupdated 3 y ago
• EExtra-Scared Scared Heartsby je suis une pomme de terreDescription You know those hearts that run away from you? Ever thought that was a bug? This mod gives them a face to make them more distinct and silly. Now with 20+ different heart types! Configuration You can turn off the hearts with spider legs using the Mod Config Menu.79.0k downloadsupdated 21 mo ago
• [[REP(+)] The Binding of Isaac Reshaken - Vol 1.5: Shattered Souls+!by 76561198995475535Over a year in the making, Team Milkshake presents to you Volume 1 of Isaac Reshaken! Isaac Reshaken is a content pack MOD that adds over 40 new high quality items, trinkets, consumables, and foes! Including: Features! 20+ shiny new items 10+ fancy new spirit orb consumables :0 10+ tasty new trin...74.3k downloadsupdated 3 mo ago
• ((AB+ ONLY) Fiend Folio - 250 New Monsters! ...and more?by ErflyFOREWORD: This version of the MOD is for Afterbirth+ ONLY However, there is a REPENTANCE VERSION linked here! Why settle for 250 new monsters when you could have 500 new monsters, 140 new items and so much more! Check it out! It's finally time to dive into Fiend Folio! From those who worked on Re...66.4k downloadsupdated 4 y ago
• ++18 XapDM0:Dby 76561198375019062( ͡°👅 ͡°) NEW GLOBAL MOD FOR ISAAC64.8k downloadsupdated 7 y ago
• BBetter Healthby Fragrant FlaaffyShiny new health bar graphics for your HUD and matching ingame heart sprites remade to match the colours! Complete with a brand new charge bar for version 2.0 and edits to the shading! :) Hope this all works fine! Please post in the comments below~ Thanks <364.1k downloadsupdated 5 y ago
• GGruesome Mimicsby AtaristicMakes mimic chests more visible with a gory Dark Brotherhood symbol. Oh, it's just a bloody handprint. As a bonus, makes it so that mimic chests don't change color when the spikes pop out!63.7k downloadsupdated 6 y ago
• HHeart tokens for the Lost!by 76561198390663903Adds a new pickup for the lost (that replaces all red hearts) that allows him to use Devil Beggars and Blood Donation Machines! Simply grab a token, then walk up to a machine! Sacrificial rooms work the same, but cost two tokens rather than one! Compatible with ModConfig! And Goat Plush!! Exclama...63.7k downloadsupdated 3 y ago
• FFaster Animationsby VeeyuBasic QoL that speeds up most potential time wasting animations, giving you a faster arcade and faster game breaks :) Allows you to spam the shell game! Compatible with Rep, Rep+, Repentogon and AB+ Click for the Lite version that only speeds up animations that happen while the game timer is paus...62.9k downloadsupdated 19 mo ago
• TTotally Unnecessary But Nonetheless Epic Giga Bomb Synergiesby 76561198876704734Funnyman Modding Enterprises is BACK! With another BANGER! (no pun intended) (they also do commissions so hit them up lol) This mod adds 12 new synergies between Giga Bombs and bomb related items. The list is as follows (and yes, they do stack.): Bob's Curse Fills the room with toxic gas that dea...62.8k downloadsupdated 22 mo ago
• TThe Binding Of Pokemon + (NO LONGER SUPPORTED)by TechTHIS VERSION OF THE MOD IS NO LONGER SUPPORTED, THANK YOU FOR HAVING DOWNLOADED THIS AMAZING MOD AND PLAYED IT!!! If you want to play the sequel, here it is, The Binding Of Pokemon + Legends Expansion (WIP) It'll be worked on by the amazing Nalejandro3 ! I'll still help on things too ! Mod by Tho...60.7k downloadsupdated 6 y ago
• SSilasby MaddogsBring the world of mad science into The Binding Of Isaac with Silas! You can use four different potions to storm through the levels: Green potions create creep at a long range Red potions are thrown far, but explode on contact Yellow potions can apply any status effect at medium distance Blue pot...59.0k downloadsupdated 10 y ago
• [[Rep] Sacred Dreams Act Iby 76561198354826432Prepare to delve into Isaac's dreams in this unofficial (duh) prequel to the original game: A new Character! Unlockable achievements! 20+ items! New trinkets! New pickups! New music! And more... The Dream Guard starts with a pocket active item: Sand Pouch Use it to apply a new status effect somno...57.9k downloadsupdated 23 mo ago
• JJohn Rod For Paperclipby 76561199097252825A popular Manga Series Jojo's Unique character John Rod Over Paper Clip Trinket57.9k downloadsupdated 4 mo ago
• SSewing machineby UdolfieMake your familiars stronger ! The Sewing Machine is a brand new machine which allows you to upgrade your familiars during a run ! This mod include also 3 new items, 5 new trinkets and 3 new cards related to the Sewing Machine. -------------------------------- The sewing machine act like a slot m...57.2k downloadsupdated 3 y ago
• BBaelby hippocrunchyYou've decided to throw away your old identity and wear a completely new face. The only problem is that it follows you everywhere. As Bael, the pools are flooded with over 80 Cursed Cat items! A mix of high risk/reward, useless, to just plain bad. The Cat insists you must take every free item you...56.8k downloadsupdated 4 mo ago
• 118+ MODby 76561199059088718This is a mod that changes the game's sprites to fit the 18+ theme. It affects the appearance of enemies, bosses, characters, items, and many other small details. This mod is a new version of an old project, invented on April 16, 2022, on which I worked. For a long time, I did not touch this mod...54.2k downloadsupdated 15 mo ago

405 pickups mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.