The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth pickups mods
Everything filed under pickups by its own author, ordered by how much it is used.
405 pickups mods, most downloaded first · newest update 29 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
405 pickups mods
- ULTRAKILL Gabriel Announcerby Jake_VoxReplaces all announcer lines with Gabriel from Ultrakill! Gabriel lines all voiced by me! Special thanks to @McSpudVA for voicing Minos in the ascent. He's awesome go show him some love :)27.3k downloadsupdated 20 mo ago
- Special Chest Pools! (Haunted and Spiked chest item pools!)by TheTurtleMelonHaunted chests and Spiked/Mimic chests now how their own themed item pools and trinket pools! (15% chance for an item, 15 % chance for a trinket) Doesn’t it seem odd that both spiked/mimic chests and haunted chests drop the same loot as regular chests, I mean who even opens spiked chests intentio...26.8k downloadsupdated 3 y ago
- POTATO PACK 1: Interesting Itemsby ☢ Nato Potato ☢A collection of over 50 items/trinkets/pickups/etc I've made, with a few tweaks here and there to make sure there's no compatibility problems between the items or with the other potatopacks and so the items can be used by any player when using True Co-op. The pack includes: Happy Shroom, Tear Bub...26.7k downloadsupdated 4 mo ago
- teto over azazelby 76561199493364271This is a simple mod that swaps some of Azaze sprites for Kasane Teto. and he swaps tainted azazel sprites for the utau teto version he changes the "soul of azazel" for teto drills This is my first mod and probably has several bugs. I hope you like my mod :].26.6k downloadsupdated 7 mo ago
- Ame & Kangel reskinby SadoThis mod replaces Eve/Tainted Eve with Ame/Kangel From Needy Streamer Overload! This mod changes a lot of things visually, this may cause problems with other mods, consider it disabling them or deleting the things you don't like in order to enjoy this reskin.26.5k downloadsupdated 3 y ago
- [AB+] Lost And Forgottenby ENFOR== Mod Comatibility Hack is required for this mod to work properly == Repentance Version The Binding Of Isaac | Lost And Forgotten ! NOW COMPATIBLE WITH SEWING MACHINE MOD ! ----------(o)---------- This mod combines my previous mods Lost Items Pack and Lost Items Pack Expansion alongside with a l...26.0k downloadsupdated 6 y ago
- Improved Hearts [REP+]by 76561198881933736Improved Hearts! This mod changes the UI sprites and pickups for all hearts in the game. ---------- Mod Compatibility ---------- Fiend Folio MOD: Reheated Extra-Scared Scared Hearts Deliverance ---------- Credits ---------- Graphic Designer, Artist: Eddie Moonbert. ✦ Artwork/Thumbnail: Steam Artw...25.7k downloadsupdated 10 mo ago
- siren trophyby 76561198825922892siren trophy siren trophy repentance plus version:25.7k downloadsupdated 4 y ago
- Satoru Gojoby HoloSatoru Gojo Gojo is a brand new playable character for The Binding of Isaac. Start the game with the Infinite Void domain expansion and play as him to uncover his new unlockable items and more! The mod is still in beta and not all items have been added or completely finished yet. Gojo Stats: - St...25.4k downloadsupdated 3 y ago
- [ECO update] Eclipsed - betaby 76561198367165319Eclipsed ECO update Play as Nadab & Abihu - explosive brothers or as Unbidden - cosmic spirit Features: +4 characters +100 items +30 trinkets +80 consumables +9 challenges +16 curses +6 new beggars +40 unlocks Characters: 2 new characters with unique gameplay, as well as their tainted versions wi...25.1k downloadsupdated 2 mo ago
- Cadaver: The Rotten Expansionby LukanineCadaver is a mod for The Binding of Isaac: Repentance that adds 11 new unlocks, a playable character, and their tainted counterpart! Explore the basement with Cadaver, Isaac's rotting corpse, and gain access to Golden Souls, Rotten Chests, and more! CADAVER Cadaver only has one rotten eye, so he...25.0k downloadsupdated 3 y ago
- Whore Of Babylon: Isaac's Secret Stash 18+by 76561199663887439WoB: Isaac's Secret Stash +18 Is a Huge Mod for +18 for The Binding of Isaac! NOTE: THIS MOD DEPICTS THE CHARACTERS AS +18 Year Olds, PLEASE DO NOT HATE ON THE CREATOR OF ANY OF THESE SPRITES Official Discord Server: Credit || The Team: MinyGold FilteredTea M4RS-4600 Barley Aioros jinman ThabithT...24.7k downloadsupdated 2 y ago
- Angelaby AltzThis mod adds a new character named Angela. She is a holy apprentice on her way to becoming a true angel. Angela's path is littered with an unholy presence that could lure her towards evil doings. • 13 New Items! • 2 Transformations • Beggar Tweaks • Mechanics ITEMS • Angela Halo: +0.3 Speed • Ha...24.5k downloadsupdated 6 y ago
- Unique Pillsby 76561198876704734this mod reskins each of the 13 different types of pills (horse pill variants included) to each look like wildly different kinds of medicine. It also reskins all 20 non-cyanide Fiend Folio pill types.24.2k downloadsupdated 18 mo ago
- Minty Lucky Pennyby ZekavaI didn't like the other lucky penny mods so I made my own.24.0k downloadsupdated 5 y ago
- Full Pickup Preventionby NikoOverview Hate wasting pickups? Does some evil force rip you to shreds every time you accidentally pick up a penny when already at 99 coins because your in a room full of pickups and you just wanted to touch the locked chest over there that looks so enticing and must have a good item in it right?...23.7k downloadsupdated 3 y ago
- Colored Runes (Resprite)by darkly77Makes vanilla rune sprites colored. Hagalaz Destroy breakables (rocks, pots, skulls) Jera Duplicate pickups/chests Ehwaz Trapdoor/crawlspace Dagaz +1 soul heart, remove curses Ansuz Reveal map Perthro Reroll pedastals (D6) Berkano Summon blue flies & spiders Algiz Shield for 20s Black Rune stays...23.6k downloadsupdated 4 y ago
- Beyondby ÉoleBeyond is a mod for The Binding of Isaac: Repentance that brings more than 60 items, 35 trinkets and 6 characters to the fray. The current version is 1.9! Most of the mod content is locked away behind 80+ achievements! The development of the mod is mostly over for now, unless I feel motivated aga...23.5k downloadsupdated 2 y ago
- [RGON+] Arachna (25+ Unlocks!) | Update 2.0: Woven Anew!by rvstyBecome the lord of the spiders with Arachna - a new character, that revolves around web and spiders. Now back with full Repentance+ and REPENTOGON support! Arachna starts with a new item in her pocket active - Arachna's Spool. She can throw it at enemies to create web that slows them down and tur...23.4k downloadsupdated 4 mo ago
- On-Time Cracked Keyby Chinpokomon_Trinkets dropped in Mom's bedroom, will each be transformed into a Cracked Key once you sleep in Mom's bed. Because life is too short for another run if you forgot this one minor thing. Source code is availible on BitBucket.23.3k downloadsupdated 4 y ago
- 11 new items!by AlphiusThis mod adds 11 new items and 2 new trinkets. Here is a list of all the items added: Cursed D6 - "Reroll with caution" Cursed Box - "Solves all problems...?" Free Shipping - "Order online" Quatrefoil - "Lucky me" Life Insurance - "Good investment" Glyph of Consolation - "May you no longer suffer...23.0k downloadsupdated 9 y ago
- BlackMarketby MaddogsIntroducing a new active item and passive item, Black Market and Rusty Scalpel! Because you didn't need those organs anyways, and a dollar is a dollar! Black Market Active item, 4 charges Upon use, Sells all heart pickups in the room to the devil for coins based upon their level, and sells any or...22.9k downloadsupdated 10 y ago
- Luck Expandedby DevMaking this work in vanilla was quite a challenge and required some extremely hacky workarounds, but it's finally here. Repentogon is NOT required, though it is recommended for a small extra performance gain What does this mod do? The quality of pedestal items now scales with luck across all room...22.8k downloadsupdated 13 d ago
- More Soul and Black Heart Typesby Iris HeartIntroduces double soul hearts, half and double black hearts into the game. Full soul and black hearts have a 2% chance to turn into double versions of themselves. Black hearts also have a 2% chance to turn into half black hearts instead. Humbeling Budle raises chance of soul and black hearts beco...22.6k downloadsupdated 5 y ago
- Anathema (Vitiated Characters) [RGON+]by 76561199012785050THIS MOD REQUIRES REPENTOGON TO WORK, IF YOU DON'T HAVE IT INSTALLED, PLEASE DO: (This mod is a complete overhaul of the (now unlisted) orignal "Anathema Mod", also known as "Vitiated Characters". Most aspects of this mod were touched up, reworked, or ditched entirely in favour of a greater, and...22.6k downloadsupdated 3 mo ago
- !Rebirth Items Vectorized ! Redone!by EMORYRebirth Vectorized! replaces all item sprites with rasterized vector art similar to that of the original Flash game, but with vibrancy of Rebirth's sprites. New art for all of Isaac's items! Check out www.emoryillustrated.com/ for a gallery of all the artwork Mods that modify 005.100_collectible....22.4k downloadsupdated 3 y ago
- Limbo Deals 2by The_Evil_PickleThis mod adds a third kind of deal room that can appear after boss fights: a Deal with the Old Gods (or Limbo deal for short). It won’t replace devil or angel deals - it appears when no other deal opens, or in rare cases alongside one of the other deals. Items in these rooms are free, and you can...22.2k downloadsupdated 4 y ago
- Agnis - The Extracorporeal [Rep/Rep+/AB+]by JSGDisclaimer: this character is a challenge, Agnis is not OP (not supposed to!), it's complicated as hell, introduces mechanics that are new to the game and it's VERY hard to master...it falls in the same category as the lost or the keeper....if you dont want that kind of difficulty and are expecti...22.1k downloadsupdated 5 y ago
- POTATO PACK 2: Game Tweakersby ☢ Nato Potato ☢A collection of the mods I've made that modify the game mechanics, most of which are totally customizable using the Mod Config Menu. The pack includes: No Health Cap, No Pickup Cap, No Pocket Cap, No Curses, No Costumes, No Empty Pedestals, Custom Starting Items, Custom Base Stats, Custom Stat Ca...21.9k downloadsupdated 11 d ago
- cat bombsby 76561198994593714completing the cat pickup trio... - replaces every bomb with (un)canny cat, including troll bombs - also replaces bomb sfx incompatibilities: - (troll) bomb resprites (duh) - little horn/big horn resprites (due to their spritesheets having been edited)21.8k downloadsupdated 2 mo ago
- Gurzil - The Transmutator [Rep/Rep+/AB+]by JSGGurzil is a character that turns gridentities (Walls, Rocks, Vases, Skulls, Poop and Polyps of the womb) into turrets. There are limits tho: * He can only have 2 turrets of each kind at the same time on the same room. Items that add more tears increase this limit (Ex: Mutant spider increases the...21.7k downloadsupdated 5 y ago
- Fun Golden Penniesby [YS7E] Master YupaSpawns all coins for a golden penny at once. Pennies will home in on isaac. Homing is disabled for keeper characters where coins can be left on the ground as health.21.3k downloadsupdated 3 y ago
- Issac missing poster itemby Vyro OneHi guys,have you ever wondered "I want to get the lost,but how the hell can I get the missing poster?" With this mod you guys are starting with the missing poster (with issac character ) and u can get the lost To enable the mod u need to enable the mod and disable all the mods u have. Steps: Step...20.3k downloadsupdated 9 y ago
- Transformations Plusby NiroThis mod buffs 12 transformations in fun and unique ways! It currently buffs all the transformations except for Super Bum, Adult, and Guppy. All the buffs are additions to what the transformations already do. You can disable buffs that you don't want with Mod Config Menu! Beelzebub gives a damage...20.3k downloadsupdated 3 y ago
- Restored Collectionby 76561198374458982Relics thought to be lost have been found, and are now in the basement! Restored Collection is a collection items, pickups, and more, restored from Antibirth to Repentance, featuring 23 items and 1 trinket! Features 23 collectibles to discover, ranging from items cut from Antibirth to items based...19.7k downloadsupdated 1 mo ago
- BetterGoldenCoinsby 76561199092966895中文版介绍放在后面哦。 Tired of running around to collect the Golden Pennies? Let me introduce this mod "Better Golden Coins!" for you. Every 0.5 seconds, the Golden Coins in the room will automatically find their way to the player. The mod might slightly make the game a little unbalanced, but don't care ab...19.6k downloadsupdated 4 mo ago
- Blue Baby Reworkby 76561198412573006Welcome to the description! As of Repentance Blue Baby is one of the worst characters, as the added difficulty is not traded off for any interesting mechanics (e.g. red hearts turning into blue flies with The Keeper), so I decided it was time for a rework. In this mod, playing as ??? (tainted or...19.4k downloadsupdated 5 y ago
- [Ultimate Sprite Collection]by ViscerAAt long last. It's been a fun ride! Now I'm gonna take a well deserved break, haha19.0k downloadsupdated 5 y ago
- [REP] The Binding Of Pokemon + Legends Expansionby 76561198429240276A MOD MADE WITH A LOT OF LOVE AND AFFECTION BY FANS, AND FOR FANS. This mod is the official sequel to "The Binding of Pokemon" from Afterbirth+ now available for Repentance. Contains characters and items from "The Binding of Legends" (Rebirth) and lots of community-contributed Pokémon content. If...18.8k downloadsupdated 3 y ago
- Even Playfield (items for monsters)by PixelPlzThe monsters learned to use items against you! Inspired by Risk of Rain 2, Even Playfield adds a unique way to spice up your runs. Each room gives your enemies a new set of items that affects them, including stat increases, new attacks, familiars and much more. Fight against wacky combos, take on...18.5k downloadsupdated 12 mo ago
- Twisty Tuning Forkby AshLet's get rifty! The Twisty Tuning Fork is an item with a 2 room recharge that can be found in item rooms and devil deals. When used, it'll summon a interdimensional rift from the same dimension Multidimensional baby comes from! Meaning it will double anything you shoot through it! It'll last the...18.1k downloadsupdated 10 y ago
- Deep laboratories [REP]by MogumiDeep Laboratories is a full reskin of The Binding of Isaac: Repentance, giving a complete visual overhaul to stages, enemies, bosses and more in an alternative technological version! Warning: the mod is big! And it replaces most of the game sprites, so having too many mods may cause various visua...18.0k downloadsupdated 2 mo ago
- Man Bombsby Danny BoyChanges the troll bombs and the giga bomb to the Roblox Man face Inspired by my friend Dinnerbone Enjoy que pro17.9k downloadsupdated 5 y ago
- [REP] T.K.C.G Our Game is Fu*king Thrivingby 愤怒的穷哥们!! This mod does not support "Repentance+" DLC !! !! This mod does not support "Repentance+" DLC !! PS: This MOD requires a pre MOD: CulLib This Mod add 120 new Item,30+characters This Mod has no English EID at all,Because English isn't my strong suit :( If you have any complaints on this mod, pl...17.9k downloadsupdated 16 mo ago
- the binning of isek: aferberts plussby Ao JonesiREPPENISS VERSION SOON MAYBE The Full Graphical Overhaul is officially back, and better than ever! One day, as Isaac descends to the basement once again, he notices that things are... off. Everything looks like his drawings or something far worse... This mod gives the entire game a new, interesti...17.6k downloadsupdated 8 y ago
- D!Edith (TAINTED UPDATE)by 76561199101563685As a result, this mod does not and will not work on Repentance+ until REPENTOGON is ported to it! Stiff as a statue, D!Edith's (not to be confused with the character with the identical design and name from Antibirth) gimmick involves being incapable of shooting tears while moving. Charging weapon...17.5k downloadsupdated 5 mo ago
- Curiosity Crate [Rep|Rep+]by CaMpeRA new and shiny box has arrived in the basement and it's loaded with interesting stuff! If you ever thought to yourself why there wasn't a giant sawblade to rip and tear your enemies or bunch of toys that can fight for you in the basement, well now you can get those and more! This collection incl...17.0k downloadsupdated 4 mo ago
- ENA MOD (26+ Unlocks) [REP/REP+]by 76561198410624511ENA has come to Isaac with 26+ new unlockables! Featuring: 1 Character (+Tainted) 19 Collectibles 4 Trinkets 1 Pickup 1 Consumable 1 Machine 2 Challenges Turron! You can also unlock everything in the "dead sea scrolls" menu Isaacguru Wiki: REPENTOGON (not required) Mod works just fine without REP...16.9k downloadsupdated 11 mo ago
405 pickups mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

