Mods / Familiars

• DDa Rules - A Sandbox Menu Thingy [Rep/Rep+/AB+]by JSGDa Rules is a sandbox-style menu that allows you to mess around with almost anything in the game, from monsters to visual effects. Sure, you can do "Every item is"...BUT you can also replace, resize, push, rotate, at tach, path, animate, change costumes and a LOT more than that. Theres extra effo...454.7k downloadsupdated 4 mo ago
• [[REP- ONLY] Fiend Folio: Reheated - 500 New Monsters!by ErflyFOREWORD This version of the MOD is for Repentance only. However, there is an updated REPENTANCE+ VERSION linked here! Why settle for less items, less monsters, and less characters? More can be found in Fiend Folio: RELOADED! Check it out! Fiend Folio MOD is back in town baby! The original MOD ha...404.1k downloadsupdated 3 mo ago
• ((+REP) Josuke and Crazy Diamondby melonNOTICE: Updated with a bugfix to make it playable with rep, a few minor improvements, functionality for Birthright, and a tainted version. The current version of the API has major bugs with stats and sounds, but I may update again once those are fixed. Check the changelog. With this mod, play as...291.6k downloadsupdated 6 y ago
• [[AB+ only] Chargebars for Brimstone & Coby WofsaugeThis mod changes the appearence of the official chargebars back to the design before boosterpack#5 ~~This is the original mod, that was added in the game patch "Booster pack #2". It is not compatible with Repentance!. Since Booster#5, it changes the sprites of the chargebars and allows for custom...253.8k downloadsupdated 9 y ago
• NNeko Tainted Lost (and The Lost!)by TrujiDo you ever like playing and dying as Tainted Lost is too painful? Would you like it to be... cuter? This mod changes Tainted Lost into catghost (?) alongside turning the holy card into nyan card. Now also featuring The Lost and some other ghostly items! Have fun and good day! 09/01/2023: Ugh I'v...247.5k downloadsupdated 4 y ago
• RRevelations (AB+ only)by SentinelWARNING This mod REQUIRES the StageAPI and Mod Compatibility Hack mods to function. Get them here and here. IF YOU HAVE STRANGE ERRORS AFTER INSTALLING THE MOD, TRY DELETING THE MOD'S FOLDER AND RESTARTING THE GAME (see below) Announcements The Chapter 3 character, Bertran, got released as a stan...215.1k downloadsupdated 5 y ago
• UUnique Minisaacsby Warhamm2000Changes every Giant Cell minisaac sprite to match parent's. Every one of them is cute! Tainteds too! Except for Samsons and Moses. These minis are grumpy Supports some modded characters by default as well! Lilith has babies, boys and girls, every one is possible (Tainted Lilith has babies too, bu...192.6k downloadsupdated 15 mo ago
• [[REP+] Andromeda (+28 Unlocks)by HybridFeatures Here’s a quick look at what this mod has to offer: Andromeda, a unique character based around Planetariums with a tainted version Full unlocks for both characters, including new items, trinkets, runes, and more Hundreds of custom costumes Special unlocks for Heaven's Call Dead Sea Scroll...189.1k downloadsupdated 6 mo ago
• RReverie - Touhou Combinationsby CuerzorReverie is a content mod inspired by Touhou Project series, with a large amount of items and characters with unique effects! 200+ new items and trinkets 3 new characters and their tainted version...or you may find someone else? 7 new alt-floor bosses 2 new secret bosses 9 new consumables A new en...166.5k downloadsupdated 14 mo ago
• OOriginal Style Meat Boy and Bandage Girlby 76561199017419812I have no idea how to write description click this link if you wanna change lil deli into tofu boy160.2k downloadsupdated 5 y ago
• AAlphabirth Pack 2: All That Is Unholyby FacemanFoothandThe Binding of Isaac Alphabirth: All That Is Unholy is the second official modpack from Team Alpha! This pack adds: > 29 new items! > 11 enemy variants! > 2 new transformations! > 1 new character! (Be weary of Black Hearts!) > 4 new runes! > and 4 new challenges that unlock content upon completio...142.4k downloadsupdated 9 y ago
• AAlphabirth Pack 1: Mom's Closetby DeadInfinityThe Binding of Isaac Alphabirth: Mom's Closet is the first of many packs to be developed by TeamAlpha! Download the complete Alphabirth collection here: This one in particular adds: > 31 new items! (including 3 unlockables) > 2 new trinkets! > 1 enemy variant! > 1 new transformation! > 1 new pick...142.1k downloadsupdated 9 y ago
• LLazy MattPack [RGON]by Mr. HeadcrabThis mod requires Be sure to follow the full install instructions on repentogon․com This pack contains all* the items commissioned by Lazy Mattman! Many of these items are unique Quality 5s, items that won't appear naturally unless certain conditions are fulfilled *D-Section is uploaded as a stan...139.5k downloadsupdated 6 mo ago
• RRevelations Ch. 2 [Rep]by FilloaxThis is the Repentance version of the mod, for the Afterbith+ version see here. This mod REQUIRES the StageAPI mod to function, and the REPENTOGON mod is heavily recommended for performance, features and to avoid download failures, and will be required in Chapter 3. IF YOU HAVE STRANGE ERRORS AFT...131.0k downloadsupdated 2 y ago
• [[RGON] Repentance Plus!by Mr. SeemsGoodThis mod requires REPENTOGON to operate, for optimization and modding convenience purposes. More Unlocks to Spice Up Your Game! Repentance Plus is a mod that adds: 59 new items; 23 new trinkets; 41 new cards; 6 new pills; 17 new heart pickups; 4 new chest variants; and a bit more? into the game!...127.5k downloadsupdated 9 mo ago
• TThe Sheriff (+Tainted)by catinsuranceGet the remaster of this mod with new content, reworks, and fixes, by clicking HERE! The Sheriff is a new gunslinger character with a revolver and no time for tears. Discover 30+ unique synergies, some of which granting unique guns and abilities! Ammo and bullets The Sheriff has 6 maximum ammo in...127.0k downloadsupdated 19 mo ago
• SSiren, Playable Character (Rep/AB+)by SuddenlySquid================================================ Mod is compatible with Repentance or Afterbirth+ but has updates in Repentance ================================================ - Overview - The Siren was a boss in the wonderful Antibirth mod (which later became Repentance). She charmed many of us...120.5k downloadsupdated 5 y ago
• NNemesisby SinstharNemesis is a new playable character, with her own shooting style ! She works almost like Lilith : she can't shoot, her familiar (some sort of flying mixture) shooting for her. All the items that normally change your tears are now useless ; you must loot Holy Flasks to modify the tears you shoot....111.3k downloadsupdated 5 y ago
• [[REP/REP+] Unique Items APIby BennyCreate your own Unique Item with ease! This mod does nothing on its own! The items shown above are examples of what the API can do when applied to some pre-existing mods. Make your own or find a mod that makes use of the API. Below is a list of mods that are known to do so, and will be updated ov...110.6k downloadsupdated 17 mo ago
• NNeko Lilith :3by JiftooTurns Lilith and the incubus into cats :3 Inspired by neko tainted lost and cain. (No compatibility with mods that change charactermenu.png and incubus spritesheet. If there's a way to make resprite mods compatible, please tell me. There should be a way, right?) Bonus: KSYC RKA3 - weird XL floor...105.9k downloadsupdated 5 y ago
• AAuri [REP/REP+] (Maintained)by 76561198337269080..One day, while Isaac was playing with toys and Isaac's mother was watching TV. There was a soft knock on the door. When Isaac and his mother opened it, they saw a mysterious little girl. She looked very tired and hungry.. Features - Add 5+ new characters - 400+ unique costumes for each characte...105.3k downloadsupdated 4 mo ago
• AAlphabirth Pack 3: The End Timesby FacemanFoothandThe Binding of Isaac Alphabirth: The End Times is the third official modpack from Team Alpha! This pack adds: > 20 new items! > 7 new enemies! > 2 new pickups! > and 1 new challenge that unlock content upon completion! This mod requires AlphaAPI to play: We highly recommend you play with all of o...99.4k downloadsupdated 9 y ago
• DDeliveranceby BaicherraNo, this mod doesn’t add any new floors, huge bosses(?) or anything like that. We’ve put some cute monsters and items which we'd like to see in the game! In general, Deliverance adds: 44 new items! 8 trinkets, 4 cards, new heart and a new pill! 30+ new enemies! 900+ new rooms! Secrets! Mod Suppor...98.7k downloadsupdated 10 mo ago
• 三三只熊中文控制台/Szx Chinese Consoleby Kev.SunThe whole mod description in English or in Chinese locates in the discussion forum due to the line limit here. The whole mod description in English or in Chinese locates in the discussion forum due to the line limit here. The whole mod description in English or in Chinese locates in the discussio...98.2k downloadsupdated 14 mo ago
• GGodmode Unleashed [AB+]by MINDS3TFor the Repentance version, GO HERE! Current features: 29 Items! 7 Bosses! 7 New Floors! 2 New Pickups 1 New Pill! 20 New Enemies! 5 New Characters! 1 New Challenge! Revamped special items system! Wait, what did you do to special items?? Don't worry, I made quite a few more items categorized as s...95.1k downloadsupdated 2 y ago
• NNeko Tainted Apollyon [+RGB]by shizo meltdownCute Apollyon kitty cats... What else is there to say?（=´∇｀=） This mod features: - Neko T. Apollyon sprites with a small (poorly) animated abyss kitty - resprites of 'Echo Chamber', 'Abyss' and 'Apollyon's Best Friend' ..and with the latest upate: - Neko Apollyon - resprites for Lil Portal, Void...92.8k downloadsupdated 23 mo ago
• DDancing Sissy!by 76561198447262219Fully compatible with Kissy Longlegs! Adds a chance that after clearing the room or encountering a good item, Sissy Longlegs will start dancing! By default, the chance of a regular dance is 20% and the chance of a rainbow dance is 2%, but you can configure everything in Mod Config Menu! Thanks fo...90.2k downloadsupdated 3 y ago
• DDarkShesauby BaicherraART PREVIEW MADE BY KinoZukna! PLEASE FOLLOW Don't you like the usual Dark Esau? Well, this mod changes Dark Esau Gender, turning your gameplay into an unforgettable fun(or hellish torment). Included: -New sprites; -New animations; -boss/stage portrait; -Death screen portrait;89.8k downloadsupdated 5 y ago
• [[REP+] Mastema (+26 Unlocks)by HybridIn the Book of Jubilees, Mastema was a fallen angel who carried out punishments, tempted humans, and tested their faith, all under God’s permission. Now, he’s made his way to the basement for you to play as! Mastema As Mastema, your life always hangs in the balance. Treasure rooms, shops, devil a...89.3k downloadsupdated 6 mo ago
• JJoJo's Kira and DIOby [TBG] Alvys14BlackWith this mod you can play as DIO from Jojo's Bizarre Adventure: Stardust Crusaders! DIO will start throwing knives and with the item THE WORLD. This item will stop time for 3s as DIO was able at the start and will summon his stand for 10s. DIO as vampire has also recovery life powers when he kil...86.2k downloadsupdated 6 y ago
• RRetribution: 190 Itemsby XalumWarning The Repentance+ DLC broke the modding api in a whole load of different ways, there is no guarentee of compatibility between this mod and the Repentance+ DLC until these issues have been fixed. If you play with Retribution while using Repentance+ you do so at your own risk and should expec...78.7k downloadsupdated 3 y ago
• EEevee: Reunited - Character Demoby BennyStatus Update from Benny The mod has, unfortunately, been cancelled for the foreeable future. There has been a lot of work put into the mod since the demo's last update, but due to mental health issues, I cannot comfortably continue development. Having a second coder on the team or me returning t...78.2k downloadsupdated 3 y ago
• SSodom And Gomorrahby XalumEnter the Basement once more with Sodom and Gomorrah. Experience a brand new 2-in-1 challenge character with strong influences from the cut Antibirth character Edith, and unlock a tainted character raized by the heavens. Features 2 brand new challenge characters complete with Birthright entries 3...72.3k downloadsupdated 4 y ago
• [[REP(+)] The Binding of Isaac Reshaken - Vol 1.5: Shattered Souls+!by 76561198995475535Over a year in the making, Team Milkshake presents to you Volume 1 of Isaac Reshaken! Isaac Reshaken is a content pack MOD that adds over 40 new high quality items, trinkets, consumables, and foes! Including: Features! 20+ shiny new items 10+ fancy new spirit orb consumables :0 10+ tasty new trin...72.2k downloadsupdated 3 mo ago
• MMaid in the Mist Candleby TheUpperHalfReplaces the Paschal Candle with a lil' Maid in the Mist familiar. Cosmetic change only.71.1k downloadsupdated 5 y ago
• OOff-screen Indicatorsby PixelPlzHave you ever just sat around blindly shooting at Delirium while he's off-screen somewhere? Have you ever lost track of your Ludovico Technique tear in a big room? Then this mod is for you! Features: Indicators for the following things when they're off-screen: - Bosses - Enemies - Ludovicho Techn...69.6k downloadsupdated 3 y ago
• LLoadoutby LytebringrThe Loadout Mod provides a quick graphical catalog of all items from all mods that can be given to or taken away from the player. Test synergies with ease. Explore the unknown depths of any mod you have activated. This mod is meant for testing purposes only and not for use during a run. With that...67.8k downloadsupdated 10 y ago
• ((AB+ ONLY) Fiend Folio - 250 New Monsters! ...and more?by ErflyFOREWORD: This version of the MOD is for Afterbirth+ ONLY However, there is a REPENTANCE VERSION linked here! Why settle for 250 new monsters when you could have 500 new monsters, 140 new items and so much more! Check it out! It's finally time to dive into Fiend Folio! From those who worked on Re...66.0k downloadsupdated 4 y ago
• BBold Brim Beamsby SprSnpr_Be BOLD with your Brimstone! I've always found the Brimstone beam to look slightly... flat. This mod darkens the edges of Brimstone's beam in order to give it a more defined look. This mod affects every version of Brimstone in the game- save for The Beast and Cage Vis' Brimstone.64.1k downloadsupdated 3 y ago
• [[Rep/+] Job 2.5 - Over 25 (+45) New Unlocks!by AgentCuccoA brand new, vanilla reminiscent expansion! Play as Job, starting with high fire rate and the new Book of Despair item, and uncover over 25 new unlockables, including items, trinkets, a tainted and more! Features: - A brand new character reminiscent of Vanilla game design, Job. - An unlockable Ta...62.0k downloadsupdated 11 mo ago
• ++18 XapDM0:Dby 76561198375019062( ͡°👅 ͡°) NEW GLOBAL MOD FOR ISAAC61.5k downloadsupdated 7 y ago
• SSigmonstroby 76561199149887702Monstro comitted to the grind and got his body back... Resprites and reanimates monstro, monstro 2 and both delirium forms. (lil' monstro too, but he has yet to get his lil delirium form) -Thumbnail art by lambchop_is_ok60.9k downloadsupdated 5 y ago
• TThe Binding Of Pokemon + (NO LONGER SUPPORTED)by TechTHIS VERSION OF THE MOD IS NO LONGER SUPPORTED, THANK YOU FOR HAVING DOWNLOADED THIS AMAZING MOD AND PLAYED IT!!! If you want to play the sequel, here it is, The Binding Of Pokemon + Legends Expansion (WIP) It'll be worked on by the amazing Nalejandro3 ! I'll still help on things too ! Mod by Tho...60.7k downloadsupdated 6 y ago
• SSewing machineby UdolfieMake your familiars stronger ! The Sewing Machine is a brand new machine which allows you to upgrade your familiars during a run ! This mod include also 3 new items, 5 new trinkets and 3 new cards related to the Sewing Machine. -------------------------------- The sewing machine act like a slot m...56.6k downloadsupdated 3 y ago
• [[Rep] Sacred Dreams Act Iby 76561198354826432Prepare to delve into Isaac's dreams in this unofficial (duh) prequel to the original game: A new Character! Unlockable achievements! 20+ items! New trinkets! New pickups! New music! And more... The Dream Guard starts with a pocket active item: Sand Pouch Use it to apply a new status effect somno...56.3k downloadsupdated 23 mo ago
• UUnlock all items and characters! (Updated for Repentance Plus!)by 76561198389860083Compatible with last patch of Repentance+! Im updated it again, finally. It still can be buggy for someone, but qualities of items, pools and etc. is fixed, have fun! Version to unlock only items This mod unlock ALL ITEMS AND CHARACTERS in game without affecting on achievements If you turn off th...53.8k downloadsupdated 21 mo ago
• IIPECAC Community Modby pedroff_1(If you're looking for the Afterbirth+ Version, click here!) (If you have the Transformations+ API and/or Mod Compatibility Hack, those are no longer required nor supported) Welcome to the IPECAC Community Mod! The IPECAC Community Mod is a mod focused around the community, and as such, a large p...50.8k downloadsupdated 3 y ago
• SSucQTbusby IvyHas the plain old, angry-looking Succubus of Afterbirth been bothering you with its completely normal appearance? Are you mad that Succubus's deal cost was raised to 2 hearts in Repentance and want something to really make it worth the HP? Worry no more, because there is now a solution for these...50.5k downloadsupdated 6 y ago

442 familiars mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.