The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth cards mods
Everything filed under cards by its own author, ordered by how much it is used.
248 cards mods, most downloaded first · newest update 29 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
248 cards mods
- LSD Consumableby ArcticPlease leave a comment, I'd love to know what you think of my first mod! It's acid! Take it and freak out. Think your parents are trying to kill you! This mod adds a consumable with a 1/32 chance to replace cards and runes. Using it will make you see crazy sh*t, man. On top of that, it applies a...3.9k downloadsupdated 9 y ago
- 10 cards packby 7656119880340664810 new cards have appeared in the basement! ·This mod adds 10 new cards with new effects to the game! Cards list: - God card *Effects: It has a 95% chance of giving you a coin and a 5% chance of giving you godhead *Spawn chance: 0.5% - Mirror card *Effects: Changes all your items (like D4) *Spawn...3.8k downloadsupdated 7 y ago
- Antibirth for AB+ (and Repentance)by im_temDo not install this if you want to play Antibirth, go to antibirth dot com instead Antibirth was made by P.E.N.I.S team, not me or even better, get yourself Repentance instead of running this, dammit! ----- Antiborne is now real, even for Afterbirth+ (now also for Repentance!) Let's be honest, yo...3.8k downloadsupdated 4 y ago
- The Binding of Pokimon Mystery Dungeon [Afterbith + Edition]by NarxThe Binding Of Pokimon Mystery Dungeon is a mod that turns Isaac's basement into pokemon mystery dungeon world, includes PMD levels, bosses soundtrack sound effects and much more... DOWNLOAD FULL VERSION HERE: mega. nz/file/yhEADZpa#X9R9MN2_tNITsbixkOxlmknccSU1cBjsD5GEUmaVbwI FEATURES: -Playable...3.6k downloadsupdated 6 y ago
- Unnerfed Item Mimicsby usernamenotavailableUnnerfs Blank Card and Placebo to back to how they used to be before Repentance, meaning all cards and pills take 4 rooms to recharge. Also changes Clear Rune to act like that as well because why not. Note that this will essentially make some of the new runes like Soul of Lilith extremely overpow...3.6k downloadsupdated 5 y ago
- [Ab+ Only] Bugfixes and Improvementsby GuilhermeThis mod is a compilation of my bugfixes and improvements mods, it has a low priority so any mod should overwrite it, maximum compatibility! All following mods are already included in this mod, don't subscribe to them! (Bug fixes) Fixed Bandage Girl Body Fixed Peep/Bloat's eye hitbox Fixed 1 Boss...3.6k downloadsupdated 6 y ago
- Holy Card Is The Weed Cardby possombull"What if isaac.. like.. got caught with a bunch of weed..." We've all wondered this at some point. But very few have dared to come up with a solution. That's all about to change. Replaces holy card's sprites, voiceover and name with that one infamous card from that one infamous vine. mod changes...3.5k downloadsupdated 5 y ago
- Homer's Epic Itemsby 76561198448106326A mod that includes Greek mythology themed items and characters. And now it's a semi-manufactures but in future it will have more and more rich content. Including but not limited to new characters,cards,rooms and monsters. This mod is compatible with EID. Wish you can enjoy this mod!3.5k downloadsupdated 3 y ago
248 cards mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

