The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth enemies mods
Everything filed under enemies by its own author, ordered by how much it is used.
359 enemies mods, most downloaded first · newest update 26 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
359 enemies mods
- Incredible Gassy over Mega Fattyby 76561198338773226IT'S JUST GETTING STARTED! Gemmy retexture mod that will change boring Mega Fatty with the famous superhero Incredible Gassy. Includes: -Gassy Sprites -Champion variants -Gassy title card there is still no 'p embedded, don't worry chud.4.0k downloadsupdated 3 y ago
- Antibirth Room Pack (Antibirth Enemies Expansion Pack)by fly_6Requirement Dumplings mod Coils mod (Most needed mod for work!!!) Antibirth Room Pack - For full Antibirth room experience! This room pack features rooms with unused and not added to Repentance enemies from Antibirth! Credits: 24Chrome - Dumplings and Coil remake mod for Repentance Public Enterta...4.0k downloadsupdated 5 y ago
- kurwa mamoby 76561198989606598replaces mother's shadow yell thing with KURWAAAA yeah thats it3.9k downloadsupdated 21 mo ago
- More Swarmersby Unending ConstipationREQURIES REPENTOGON! Download it at their website Adds 4+ new swarmer-like enemies to overwhelm you! These guys are mostly found in Chapter 3 with a few scattered around the main path Please report any issues in the comments and I'll try to fix them as soon as possible.3.9k downloadsupdated 22 mo ago
- AwfulTweaks [RGON]by Mr. HeadcrabThis mod requires Be sure to follow the full install instructions on repentogon.com Are you sick of the standard, well-thought-out challenge mods out there? Have you found yourself wanting a mod made primarily for the enjoyment of anyone watching you play? This might be the mod for you! This mod...3.9k downloadsupdated 4 mo ago
- [Touhou] Koishi Komeiji as Dark Esau (+Satori as Darker Esau)by 76561199017960970Replaces Dark Esau with Koishi Komeij and birthright Dark Esau to Satori Komeiji from Touhou Project. So if you think being chased by an angry brother isn't good enough, how about an airheaded sister? (replaces the .anm2 as well, keep that in mind)3.9k downloadsupdated 5 y ago
- Meat Wormby CarterG4Turns the Round Worm enemy into Meat Worm - also works with champion variants Includes meat sounds for the worm spit sounds, which may make other enemies sound like meat3.9k downloadsupdated 5 y ago
- Four Souls Big And Little Hornby 76561199058109437Resprites Little Horn and Big Horn into an appearance resembling that of the Big Horn Four Souls Card (I would have done both in their respective cards, however Little Horn did not have a card that looked similar to the Big Horn one) I spent like 5 hours on big horn alone ;-; Changes: -Big Horn -...3.9k downloadsupdated 17 mo ago
- (REP) Modified Armorby ΘΔBig thanks to the author, hgrfff, for the original mod. ---------- Allows the scale of the in-game damage armor given to specific bosses and enemies to be freely modified. By default, this mod gives affected bosses a 30% damage scale, and removes the armor given to regular enemies. The full list...3.9k downloadsupdated 5 y ago
- Dank Lust (a lust variant)by Guilhermethis mod add a variant to lust and super lust the normal lust just chase the player the dank lust creates black creep and spawn spiders he have 25% of chance to replace lust3.8k downloadsupdated 3 y ago
- 10 cards packby 7656119880340664810 new cards have appeared in the basement! ·This mod adds 10 new cards with new effects to the game! Cards list: - God card *Effects: It has a 95% chance of giving you a coin and a 5% chance of giving you godhead *Spawn chance: 0.5% - Mirror card *Effects: Changes all your items (like D4) *Spawn...3.8k downloadsupdated 7 y ago
- Antibirth for AB+ (and Repentance)by im_temDo not install this if you want to play Antibirth, go to antibirth dot com instead Antibirth was made by P.E.N.I.S team, not me or even better, get yourself Repentance instead of running this, dammit! ----- Antiborne is now real, even for Afterbirth+ (now also for Repentance!) Let's be honest, yo...3.8k downloadsupdated 4 y ago
- Buggier Bugs [DISCONTINUED]by 76561198417302118A standalone version of the better flies and spiders from my other mod. Enjoy This mod changes the appearance of most of the fly and spider enemies to make them look a bit cleaner and overall better. Sprites currently used are made by Nioffe but i plan on replacing them with new ones in a future...3.7k downloadsupdated 5 y ago
- Pizza Beastby MADAOIt's PIZZA BEEEEEEEEEEEEEEEEEEEEEEAST!!!3.7k downloadsupdated 3 y ago
- Honeyvee's Resprites + Improved and Reworked Foes Compatibility!by 76561199022951369This mod adds compatibility for Honeyvee's Resprites and Improved and Reworked Foes so you can use them together, fixing any conflicting sprites. Also adds some other things that technically didn't conflict with the mod, but were added anyway for consistency. This mod affects; Soft Hosts (Red Har...3.7k downloadsupdated 13 d ago
- Fightable Mother's Shadowby catinsuranceRequires REPENTOGON For more information, visit FIGHTABLE MOTHER'S SHADOW Ever thought the Mines escape sequence for Knife Piece 2 was too long or tedious? Or maybe, you just wanted to shake up the experience after going alt path every time? This mod turns Mother's Shadow into a boss fight. Defea...3.7k downloadsupdated 12 d ago
- Boss Rushby Oscarfcb4----------------------------------------------------------------------------------------------------- Boss Nightmare! No enemies, only bosses. To hard for you? No worries, in every floor (and in the first treasure room) you'll get two extra items. Good luck! The mod kill all enemies in rooms and...3.7k downloadsupdated 5 y ago
- The Binding of Pokimon Mystery Dungeon [Afterbith + Edition]by NarxThe Binding Of Pokimon Mystery Dungeon is a mod that turns Isaac's basement into pokemon mystery dungeon world, includes PMD levels, bosses soundtrack sound effects and much more... DOWNLOAD FULL VERSION HERE: mega. nz/file/yhEADZpa#X9R9MN2_tNITsbixkOxlmknccSU1cBjsD5GEUmaVbwI FEATURES: -Playable...3.6k downloadsupdated 6 y ago
- [Ab+ Only] Bugfixes and Improvementsby GuilhermeThis mod is a compilation of my bugfixes and improvements mods, it has a low priority so any mod should overwrite it, maximum compatibility! All following mods are already included in this mod, don't subscribe to them! (Bug fixes) Fixed Bandage Girl Body Fixed Peep/Bloat's eye hitbox Fixed 1 Boss...3.6k downloadsupdated 6 y ago
- BROTHERby HengusMA complete reskin of the Mother boss fight, but INSTEAD OF GETTING YOUR ASS KICKED BY A STUPID DUMB BOSS THAT RESEMBLES YOUR MOM, YOU'RE GETTING YOUR ASS KICKED BY THE HULKSTER HIMSELF, BRRRROTHERRRRR! OOOOOH, YEAH, BROTHER! WE'RE GONNA THROW DOWN IN YOUR MOTHER'S CORPSE, BROTHER! WHY AM I HERE?...3.6k downloadsupdated 5 y ago
- Pog Plum Titleby SprSnpr_The newest iteration of memes making their way into the game via community-made nonsense. Heavily inspired by the "POG for Good Items" mod, which can be found here:3.6k downloadsupdated 5 y ago
- Dark Spiny Shellby 76561198368618066Dark Esau decided to take a break on his revenge on Jacob, and is letting the Spiny Shell from Mario kart do all the work instead. Prepare to race against a crazy flying shell, which destiny is to destroy you, at any prize. You can even obtain a second shell with Birthright, if it's not enough! U...3.5k downloadsupdated 5 y ago
- Different Looking Portalby HaptyThis mod changes how the portal spawner looks3.5k downloadsupdated 10 y ago
359 enemies mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

