Mods / Items

• AAmalgamby NeoDementThis item counts as 1 of the 3 items needed towards any transformation! For example, if you have this item, and then pick up two Guppy items, you will become Guppy! It also gives you one soul heart, as a treat. Specifically, this item will contribute towards the Beelzebub, Guppy, Bob, Conjoined,...14.2k downloadsupdated 5 y ago
• TThe Typing of Isaac!by PoondaedalinI hope you can type fast, because the enemies can run faster! St. Dvorak's Tablet can be found in the Treasure Room pool, and its effect causes enemies to display text below their sprites. Typing in the word displayed deals heavy damage to the enemy proportional to Isaac's damage and the length o...14.1k downloadsupdated 2 mo ago
• VVitamin V Item Packby KingBobsonThis mod adds 12 new items and 4 new trinkets to the game, across a variety of pools. Be dazzled! Be amazed! All the ideas in this mod are from various anons. Most of the sprites are from stewartisme, with some anonymous contribution. Includes support for EID and Encylopedia! WARNING: The Univers...14.0k downloadsupdated 4 y ago
• [[AB+ ONLY] Golden Stopwatchby ErflyWorks just like it used to. Functions just like the pre-nerf Stop Watch, but doesn't replace the regular Stop Watch. This means it always slows enemies, slows the music, and gives a little speed upgrade. However, it also means that it's a special item. This item can be found in secret rooms, and...14.0k downloadsupdated 10 y ago
• Aamong us vent-ricle razorby vomitwaterHello? Is this among us? Impostor? Is this the impostor from among us? changes the ventricle razor to be SUS AF13.9k downloadsupdated 6 y ago
• IIsaac is susby 76561199080435951OH MY F*CKING GOD, ISAAC IS SUS THE FINAL UPDATE IS HERE BOY The mod adds a new character and his the taintend version, also add a new item and replace some textures and music (Ghost Mother is Jerma sus, Dogma is sus and we are living in the light but is STOP POSTING ABOUT AMONG US) theres also a...13.9k downloadsupdated 5 y ago
• RRadial Shotsby ☢ Nato Potato ☢Radial Shots allows you to charge up shots and release them in various directions around you, similar to mom's eye, loki's horns or tammy's head. By holding attack each tear you would fire is 'stored', up to 8 tears can be stored, if 8 are already stored shooting occurs as normal, when you realse...13.9k downloadsupdated 9 y ago
• MMore Mushrooms! [AB+]by JSJoshBecause you can never have enough mushrooms! This mod adds 10 new passive mushrooms to the treasure, secret, and boss pools, with a few interesting effects to boot! Also makes fun guy a LOT easier to get! Odd Mushroom (Bulbous) Found in the treasure and secret room pools Increases damage and give...13.8k downloadsupdated 8 y ago
• LLost Items Pack [NEW WOMB UPDATE]by ENFORLost Items Pack Mod Made by Enfor 41 + new items 26 Passive Items 10 Active Items 5 Trinket NEW EXPANSION AVAILABLE ROBOT REWORK !!! WOMB UPDATE NEW CHARACTER ROBOT NEW ITEMS Pubes Testament Blue Heart Pact of Blood Tears of joy Core NEW COSTUMES, SYNERGIES AND BUGFIXES ---- DIVIDED 1 heart + 3 s...13.8k downloadsupdated 7 y ago
• Vv1.5 Ephemeraby 76561198409938407Features Adds 25 new items to the game! 16 passives Bleach, Bush Helmet, Other Eyes, Cap-Cast, Lil' Bishop, Dream Coat, Forked Cord, Carbon Copy, Unholy Mantle, Lab Experiment, Devolution Serum, Blue Tick, Calis, Cabbages and Greens, Pop Rocks, Shadow Monkey 9 actives Static Speaketh, Folder, Fat...13.7k downloadsupdated 12 mo ago
• NNo More Useless Items: Afterbirth+by Flap_Jack2.0 UPDATE! Added support for The Forgotten! Covers all items up to and including Booster Pack 5! Keeper is now rescued from death if you get Abaddon on an item reroll! Thank you all for your continuing support! -------------------------------------------------------------------------------------...13.7k downloadsupdated 5 y ago
• FFriday 13by ElRichMCPassive item that increases your stats depending on your luck13.7k downloadsupdated 10 y ago
• IIt's Going Down Now for Good items (DROP VERSION)by PeridarrenDISTURBING THE PEACE, LOOK INTO MY EYES Wanted a version where it starts at the drop instead? WELL HERE YA GO! The Specialist dance but instead it uses It's Going Down Now from Persona 3 Reload. Full song version If you wish to use it with Reaction Port Pack instead, someone made a mod that adds...13.7k downloadsupdated 20 mo ago
• AAerosmith (Narancia's Stand) (Not yet Repentance-Compatible)by Bagre☆Hi, it's me again with another JoJo's Bizarre Adventure Mod... Aerosmith, is a miniature fighter aircraft full of a deadly arsenal.13.7k downloadsupdated 8 y ago
• IItem Expansion Baseby KyoZM---Base Expansion--- Item: "Demon Heart" Description: "Bleed for me!" Effects: HP+1 DMG+1.5 Item: "Heretic" Description: "Angels Fall!" Effects: DMG+1 Makes Mega Satan path viable with devil precident. Adds Angel statues to devil deal rooms. Item: "Reckoning" Description: "Divine judgement befall...13.6k downloadsupdated 10 y ago
• PPOTATO PACK 4: Bums & Beggarsby ☢ Nato Potato ☢A collection of the bum and beggar related mods I've made, with a few tweaks to ensure compatibility with True Co-op. The pack includes: Dead Beggar, Item Beggar, Brawler Beggar, Doctor Beggar, More Bums, Some More Bums, Even More Bums, A Few More Bums & Dogwhistle. I recommend also getting the B...13.6k downloadsupdated 1 mo ago
• JJupiter is now League of Legendsby TheCreativeGodI just changed Jupiter name and icon to League of Legends13.6k downloadsupdated 18 mo ago
• DDaydream all Dayby 76561198402142170Let's step into this wonderful DAYDREAM, and experience items and characters that can only be imagined in your dreams! Features "Daydream All Day" is a mod with 100+ dreamlike new items, trinkets, and characters. All items are filled with unique effects, allowing you to experience infinite pleasu...13.6k downloadsupdated 15 d ago
• FFlea as Big Fanby SiestasHey there! Silksong was probably my favorite game of the previous year, I love these pretty little things, so I did this mod, hope you like them too. This mod replaces the Big Fan fly with a Flea from Hollow Knight Silksong also, fleas say awoo randomly. Saludos! Silksong fue mi juego favorito de...13.6k downloadsupdated 10 mo ago
• PPotheadby ScayzePot head! Turn enemies into pots! Pot head (yes, really) is an item you can find in item rooms that give Isaac a very low chance to fire a hex tear, that'll turn whatever it hits into a pot! There are currently 4 different types of pot that can spawn and each do their own area effect when "shatte...13.5k downloadsupdated 10 y ago
• EExtended Zodiacby The_Evil_PickleAdds items from the Hiveswap Extended Zodiac. This mod is not currently updating with new content, but I may return to it in the future. I do not intend to make items for all 288 signs, because that would be absurd. I’ll just keep adding new ones until I run out of ideas. Currently, 28 new items...13.5k downloadsupdated 9 y ago
• SSatanic Ritual (Booster Pack #5)by NiroEDIT: This item is now in booster pack 5! The name has changed to 'Sacrificial Altar'. Sacrifice your familiars to satan for devil items! This one time use item sacrifices 2 random familiars in the room, and gives you a random devil item for each familiar. It also sacrifice every blue fly/spider...13.5k downloadsupdated 9 y ago
• IImproved Spritesby 76561198441604374Mod changes 100+ sprites of items thats pretty much it. I will most likely stop updating this mod, as Isaac has become quite boring for me.13.5k downloadsupdated 23 mo ago
• RRemielby ☢ Nato Potato ☢Remiel is an angelic character that has a unique attack type, always gets angel rooms and converts black hearts into bone hearts. Remiel attacks by firing ripples of light, these ripples move slowly and weaken over time, but they deal continuous contact damage and grow to cover a wide area, allow...13.4k downloadsupdated 22 mo ago
• TTech Arrowby NiroTech Arrow Isaac now fires arrows that shoot lasers. Many cool synergies: Tiny Planet Ludovico Anti Gravity Pop! Soy Milk Ipecac Haemolacria Spoon Bender Rubber Cement Monstro's Lung Mom's Knife Brimstone Technology Tech X And more... Credits Code / Art / Idea - by Niro13.4k downloadsupdated 4 y ago
• VVirtue Itemsby 76561199121244854This mod adds 7 new items, each based off a heavenly virtue: Chastity, Temperance, Charity, Diligence, Kindness, Patience and Humility. It also adds a new transformation for those items: Saint. For more details, watch the YouTube video on the mod page, or go to IsaacGuru Requires REPENTOGON13.4k downloadsupdated 2 y ago
• [[RGON]Benighted Soulby 76561198366643385!!!ATTENTION!!! REP+ is unrecommended, it may cause unknown issues REPENTOGON is necessary - What's in it? · 11+1 characters with complete unlock-trees! · 200+ items! · 3 transformations! · 6+1 bosses! · 11 challenges! · 2 curses! · More rooms! · More poops! · More bugs! - What's in the future? ·...13.4k downloadsupdated 17 d ago
• BBee Modby JoeEver felt like the game was missing something? That something was bees! This mod adds three new items, a trinket all related to bees Glazed Heart - 1 HP up - Bees will periodically spawn Honey Pot - Upon breaking will leave a trail of honey and spawn 5 bees Lil Bee - Works like rotten baby but fo...13.3k downloadsupdated 10 y ago
• BBetter Clicker!by im_temThis mod reworks the Clicker item. Now you can choose the character you want to turn into! But be careful with who you choose since Clicker is now one time use item!13.3k downloadsupdated 6 y ago
• EEvery Item Is Xby calvinhobbes1010You ever wanted to challenge yourself with a run where every item you take is only one kind of item (such as Soy Milk)? Do you love (/s) bringing up the debug menu a lot? Do you find yourself in an eternal state of tedium where challenges like this are your only source of joy in life? Well, this...13.3k downloadsupdated 8 y ago
• AAlways Angel/Devil Roomsby littlenewbieGuarantees Angel and Devil rooms by starting with both Goat's Head and Duality.13.2k downloadsupdated 8 y ago
• IIsaac's Keyboardby anchikaiThis mod will no longer receive updates. Play Furtherance instead! Is R Key not enough for you, and you wish you could press all the various keys with an active item instead? Introducing, Isaac's Keyboard! This mod introduces 11 brand new keys to the game that all spawn in the secret room: Esc Ke...13.2k downloadsupdated 5 y ago
• SStart Item Optionsby ۩۞۩ FerMod ۩۞۩This mod adds four initial items options to choose from in the starting room. These items are spawned from the treasure room item pool. Because of this, the treasure room of the first level is always empty. Although, when the level has the 'Curse Of Labyrinth', the second entered treasure room wi...13.2k downloadsupdated 4 y ago
• BBetter Books Spritesby WambarimbaBooks resprited. Animations (like using the Monster Manual or Necronomicon) are not made yet.13.2k downloadsupdated 3 y ago
• DDevoid: Apollyon Reworkby 76561198412573006Devoid This Apollyon rework centralises around making the character more fun to play by introducing a new gimmick to the character, and changing the void active item to both be less complicated usage whilst also tying in with the new gimmick. Locust Portals Apollyon now starts with an innate abil...13.2k downloadsupdated 3 y ago
• SSeraphim Miku respriteby 76561199107851733Replaces the familiar sprite "Seraphim" with a miku13.2k downloadsupdated 1 mo ago
• SSer Junkanby 10⁻³ m³Strange, sentient junk. It appears eager to join you on your quest. Item Name: Ser Junkan Type: Passive, Familiar Item Pool: Treasure Room, Golden Chest. It also has a small chance of replacing regular junk. Description: Ser Junkan follows the player around and targets enemies. Blowing up item pe...13.2k downloadsupdated 9 y ago
• CCursed Orbby 76561198381531725The Cursed Orb is a collectible meant to act as a reverse-ish Sacred Orb. Every item pedestal will spawn doubled, but with a cost! Every item with a quality of 3 or higher gets rerolled. (The tradeoff isn't as big as it sounds, don't worry) Truji made the sprites. If you are playing with rep+, ch...13.1k downloadsupdated 5 y ago
• [[OBSOLETE] Tainted Lazarus Buff v2by TopherEDIT: mod is obsolete now, tainted lazarus finally got finished the mod is still useable, however you'll get a ridiculous amount of items. if you've 100%ed the game, or you hate laz as much as we do, this mod is for you i guess (Not affiliated with the other mod. Try both and see which you prefer...13.1k downloadsupdated 5 y ago
• $$19 fortnite cardby 76561198363305736Who wants it? -------- not supported. use instead13.1k downloadsupdated 5 y ago
• PPudding And Wakaba [REP/RGON/WIP]by 리셰The various uncommon girls arrived to basement! REPENTOGON/REPENTANCE ONLY! Does not work with Afterbirth+! Requires External Item Descriptions(English/Korean/Chinese(wip)) Mod Includes : 11 Characters 80+ Items 15+ Trinkets 15+ Card/Runes 10+ Pills 20 Challenges Items Under construction, Using E...13.1k downloadsupdated 11 mo ago
• DDuke (2 New Characters + 20 Unlocks!!)by ryonTHIS MOD IS NO LONGER MAINTAINED. Some parts might still work, but at this point it is probably pretty broken. We will not be pushing any more updates or fixing any more bugs. Sorry! Do you like flies? Do you wish that your heart was replaced with flies? Maybe the rest of your internal organs too...13.0k downloadsupdated 4 y ago
• AAuri Eid 汉化by 76561198423610277Auri的汉化mod 目前只实现了EID汉化 mod无效请先检查一下mod列表，eid、Auri、AuriEidChinese是否加载并启用了 忏悔+版本，请检查edi本体语言设置是否改为了中文(默认英文) 各角色解锁方式(可能已过时) Auri: 使用以撒获得"满分答卷"(A+) Dark Auri： Auri获得全部困难模式的通关标记 Witch of endor: 在一局游戏里获得3个幸运币 HANG GIRL：使用AURI死于非自伤4次。@Mingmen 提供的测试 Milcah: 使用Auri通关游戏，并受到敌人超过19次的伤害。 不完全看懂， 感觉是这么个意思， 原文： Un...13.0k downloadsupdated 4 mo ago
• SSlouched Beeby 76561198996706177"The mod ever." This mod simply resprites Cube Baby into Honeydrop from Fiend Folio on a chair.13.0k downloadsupdated 3 y ago
• TThe Mirrorsby ☢ Nato Potato ☢This mod adds 5 different mirrors to the game, 3 passive items, 1 active item and 1 trinket, the Portrait Mirror, the Landscape Mirror, the Cursed Mirror, the Hydrophobic Mirror and the Item Mirror. The Portrait and Landscape mirrors add a 'reflection' of Isaac into the game as a familiar/friend,...13.0k downloadsupdated 22 mo ago
• KKissy Longlegsby KodaichiShe loves you (and it shows!) This mod makes Sissy Longlegs able to kiss you, that's basically it. Since the ideal spider-kissing experience varies between individuals, there are various configurable options and features. Detailed Features: + Sissy gives kisses. One for free when you get her, and...12.9k downloadsupdated 5 y ago
• OOMORI (Character Mod)by 76561198813796283THIS MOD REQUIRES REPENTOGON TO WORK “Wow, it really is you. It’s been a while, but you haven’t changed a bit.” ------------------------------------------------------------------------------------------- Everything's better with friends; even the exploration of hellish, metaphorically-rich dreams...12.9k downloadsupdated 10 mo ago
• BBetter milkby 76561199155657668this mode changes soy milk and choccy milk textures to look more like almond milk12.9k downloadsupdated 4 y ago

1.3k items mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.