The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth sound effects mods
Everything filed under sound effects by its own author, ordered by how much it is used.
740 sound effects mods, most downloaded first · newest update 29 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
740 sound effects mods
- [Ab+ Only] Bugfixes and Improvementsby GuilhermeThis mod is a compilation of my bugfixes and improvements mods, it has a low priority so any mod should overwrite it, maximum compatibility! All following mods are already included in this mod, don't subscribe to them! (Bug fixes) Fixed Bandage Girl Body Fixed Peep/Bloat's eye hitbox Fixed 1 Boss...3.6k downloadsupdated 6 y ago
- Killer Queen "Click" Effect for Detonatorby РусскийA simple mod adding "Click" sound for "Remote Detonator". Now feel yourself like user of stand "Killer Queen" and blow them all up! How fun: 1. "~" (open console) 2. g c137(get detonator) 3. spawn 5.40.4(spawn golden bomb) 4. blow up everyone and everything3.6k downloadsupdated 9 y ago
- The Binding of Alejandro: Afterpenes+by Garuriru¡Con este increíble mod nunca más te faltará daño! Bienvenido a la recreación estilo Alexelcapo "Alejandro" de The Binding of Isaac. Este mod sirve como tributo para Alexelcapo y sus fans. Aquí encontrarás elementos característicos de Alexelcapo, como sus memes… Espera… ¡NO PODÉS!. También encont...3.6k downloadsupdated 9 y ago
- Chavo damage soundby 76561198825922892Changes the hurt sound to the one from El Chavo (hat not included)3.6k downloadsupdated 4 y ago
- Low Tier Dad Over Suicide Kingby 76561198381395222Replaces the Suicide King card's voiceline with a brand new one featuring Isaac's one and only father, who recites a teeny tiny part of Low Tier God's speech via some rough sentence mixing.3.6k downloadsupdated 3 y ago
- BROTHERby HengusMA complete reskin of the Mother boss fight, but INSTEAD OF GETTING YOUR ASS KICKED BY A STUPID DUMB BOSS THAT RESEMBLES YOUR MOM, YOU'RE GETTING YOUR ASS KICKED BY THE HULKSTER HIMSELF, BRRRROTHERRRRR! OOOOOH, YEAH, BROTHER! WE'RE GONNA THROW DOWN IN YOUR MOTHER'S CORPSE, BROTHER! WHY AM I HERE?...3.6k downloadsupdated 5 y ago
- moaiby DarianChanges the head sprite used for the Gnawed Leaf and reverse chariot card, also replaces the voiceover for reverse chariot3.6k downloadsupdated 5 y ago
- Catalog (now in game as Keeper's Box!)by TremisUPDATE: This item is now functionally in the game as Keeper's Box. Item is now obsolete as a result but I couldn't be happier! Hope everyone enjoys this as a permanent part of Isaac! Item Description: A holiday-themed item that hearkens back to simpler times. It can be found in shops, libraries,...3.6k downloadsupdated 9 y ago
- Audible Holy Mantleby DannyIsInHell ᑎᐱholy mantle got nerfed to only give invincibility for .5 seconds. This sucks because the visual reaction speed for most humans is around .35 seconds. This mod hopes to fix that by replacing the simple glass shattering noise with an earpiecingly distinct siren that is sure to be noticed. Since aud...3.5k downloadsupdated 6 y ago
- Baby Plum to :plumagony:by Mr. HeadcrabChanges Baby Plum to look like the emote :plumagony: Also edits Fruity Plum and Plum Flute and it's sound effect3.5k downloadsupdated 14 mo ago
- holy mantle vine boom sound effectby 76561199031689984Vine boom sound effect play when holy mantle gets shattered.3.5k downloadsupdated 5 y ago
- Nepu Tear Sounds (Rep/AB+)by malice liddellWhy did I do this? Don't download this. It's stupid & dumb-stupid. (Changed the tear sounds to Neptune saying nepu) Boom, there ya go, an MoI link3.5k downloadsupdated 8 y ago
- 'It's Pizza Time!' over Berserkby 76561198345870300Replaces the music for using Tainted Samson's Berserk, BERSERK!, and Soul of Samson with 'It's Pizza Time!' from Pizza Tower3.5k downloadsupdated 4 y ago
- HertaCubeBabyby Gritt[+] Added Herta as Cube Baby No Sound as a separate Mod. This mod breathes new life into the trusty Cube Baby, transforming it into a smol Herta that will accompany you on your perilous journey through the depths. Prepare to be mesmerized as this once humble cube-shaped familiar receives a comple...3.5k downloadsupdated 3 y ago
- Gabriel's Defeat Speech Over Your Deathby 76561198432528665Gabriel from ULTRAKILL speaks for you when you die. (★) This mod uses lua to play this sound, so this must be 100% compatible with other sound effect/music mods of any type.3.5k downloadsupdated 4 y ago
- Holy Card Is The Weed Cardby possombull"What if isaac.. like.. got caught with a bunch of weed..." We've all wondered this at some point. But very few have dared to come up with a solution. That's all about to change. Replaces holy card's sprites, voiceover and name with that one infamous card from that one infamous vine. mod changes...3.5k downloadsupdated 5 y ago
- [Rep+ compatible] Better Call Saul Transition Musicby TheDevilsrevengeREP+ compatible, i just did a quick run and it seemed like the mod works, Funny little meme mod that changes the floor transition music into the intro of Better Call Saul If the mod doesn't work for you, check if there are any other mods that maybe interfere with it, otherwise leave a comment so...3.5k downloadsupdated 4 y ago
- Homer's Epic Itemsby 76561198448106326A mod that includes Greek mythology themed items and characters. And now it's a semi-manufactures but in future it will have more and more rich content. Including but not limited to new characters,cards,rooms and monsters. This mod is compatible with EID. Wish you can enjoy this mod!3.5k downloadsupdated 3 y ago
- planktonby 76561199370611425chenges death to plankton aaaaaugh3.5k downloadsupdated 22 mo ago
- Jack in the Boxby EstrogenGirlJack in the Box Mod Design and Art by CatnipOverdose Coding and Trailer by AstroPenguin642 This mod adds an active item to the game called Jack in the Box. It is recommended to play this mod either blind, or after watching the video, as the effects of the item are fun to figure out. Jack in the B...3.4k downloadsupdated 9 y ago
740 sound effects mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

