The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth tweaks mods
Everything filed under tweaks by its own author, ordered by how much it is used.
1,627 tweaks mods, most downloaded first ยท newest update 29 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
1.6k tweaks mods
- cuter embryosby 76561199169078226makes embryos cute includes blastocyst & delirium5.0k downloadsupdated 16 mo ago
- Boss Resprite - The Bloatby FerpeA simple resprite of the Bloat based off of its Vs. portrait and one of the Four Souls cards. It does replace his anm2 file but it's just switching some frames around, there are no gameplay changes and you can probably override it and it'll be just fine. It even has its champion and Delirium spri...5.0k downloadsupdated 4 y ago
- Tboi: Rerolledby 76561198941199839Reroll! This mod adds 8 new unique dice and overhauls the sprites of already existing dice!5.0k downloadsupdated 3 y ago
- Siren singing is now Hog Rider!by Hideo KojimaI saw a post on the tboi subreddit made by u/Uh0hSpaghetti0hs about how similar Siren singing is to Hog Rider's, so I decided to turn it into a mod =D5.0k downloadsupdated 4 y ago
- Beast Madness Combatby 76561199086539150This mod aims to change all Harbingers and the Beast into Madness Combat characters :The Beast will be added soon Big thanks to my friend Jebus for all the sound effects please check out their Madness mods as well Changes Bosses: Death Conquest Ultra Death Ultra War Ultra Pestilence Ultra Famine...5.0k downloadsupdated 5 y ago
- [REP] Godhead Unnerfby MiyukkiMake tears aura's damage again depend on your damage, same as before Repentance You can get this modification in my Repentane Unnerf Pack too5.0k downloadsupdated 5 y ago
- The Most Beautiful Flat Stone on the Workshopby possombullWow! Flat stone looks terrible! I hate looking at it! If only there was another way! Introducing the most recent ingenuety- a resprite mod. Simply click download to get started!5.0k downloadsupdated 4 y ago
- Tainted Cain holds Lucky Toe and Justice!by raineAs the title states, this is a simple mod that gives Tainted Cain the Lucky Toe trinket and the VIII - Justice tarot card! Despite his unique crafting mechanic, T. Cain to me felt somewhat underpowered compared to the other tainted characters. This mod remedies that by helping him out with a tiny...5.0k downloadsupdated 5 y ago
- Fluttershy as Apollyon (Tainted Apollyon Update!)by AshleyFluttershy skin for Apollyon & Tainted Apollyon! :35.0k downloadsupdated 16 d ago
- Error Room Musicby 76561199017158324Adds custom music for the i-am-error-room!! I always thought it seemed weird that this room doesnt have its own music. Uses Libet Delay by The Caretaker (legend)5.0k downloadsupdated 15 mo ago
- Delirious R Key!by 76561199022951369Ever wanted to get more completions marks past Delirium? Me too! This mod makes it so after defeating Delirium, it drops a new item called "Delirious R Key". This item works nearly identical to R Key, except that it grants 6 broken hearts. This allows the player to get more completion marks in a...5.0k downloadsupdated 3 mo ago
- 1up sfx to Gi-Hun '' i've Played these games before''by 76561198834299710Changes the 1up sfx with Gi-Hun's phrase ''I'VE PLAYED THESE GAMES BEFORE'' From Squid Games Season 2, get it? cuz you revive so you play again. idk, i just can't stop saying it and i wanted to mod something ---------- Conflicts: everything that changes the sfx of this item ----------- ha-ha, i'm...4.9k downloadsupdated 22 mo ago
- Victory Lapsby โข Nato Potato โขPretty simple, the mod gives you the ability to start a new victory lap at any time, just hold V or use the Mod Config Menu to start a victory lap, you can also set whether 3 or more laps changes the character into the lost and change the hold key from V to something else by using the menu. This...4.9k downloadsupdated 5 y ago
- Even more options!by ShirtAndTielerThe combined benefit of "There's Options" and "More Options", with even more! Each treasure room and (relevant) boss reward gives you 3 options to choose from, with some treasure rooms having 4. Like the original items, you can only choose 1! Some decisions are easy, others are harder.... With th...4.9k downloadsupdated 2 y ago
- Old Restockby NeylickPrices will not increase after a shop restock. Compatible with and4.9k downloadsupdated 2 y ago
- Alt Introsby skit_inventorThis mod adds intros from Ridiculon's Repentance OST to the following alt floors: Downpour Dross (shortened intro) Mines (shortened intro) Mausoleum Corpse (shortened intro) Requires Soundtrack Menu Mod to work4.9k downloadsupdated 5 y ago
- Eric Cartman Laugh On Deathby 76561198848346428Eric Cartman laugh on death4.9k downloadsupdated 3 y ago
- The Beast but it's Gokuby 76561199001135640I've had this funny idea in the back of my head, and I had decided to make it. This is not at all supposed to be a very high quality mod and was mainly just something made for fun, but I hope you all enjoy goku from the binding of isaac.4.9k downloadsupdated 4 y ago
- [REP] Tech X Unnerfby MiyukkiLet's make Tech X great item again! With this mod Tech X gives the same damage as player's damage, independently on charge time, the same as before Repentance You can get this modification in my Repentane Unnerf Pack too4.9k downloadsupdated 5 y ago
- Disable Greed Buttonby Jenuma--==Description==-- This mod disables and disarms the arena Greed button in Greed mode that starts and stops the waves until the room is clear. This effectively means once you press the button, you have to complete all 8/9 waves (or both boss waves) uninterrupted, but the button will no longer ha...4.9k downloadsupdated 7 y ago
- True SpiderMod NEWby Dr. VindictaI am currently not working on the mod but if anyone wants to help upgrade the code they are free to send me a message and I will credit you for it in this description True Spidermod is a health and damage display it shows up on monsters and bosses and is now fully customisable with MOD CONFIG MEN...4.9k downloadsupdated 23 mo ago
- Mausoleum Visageby 76561198374458982The Visage has been re-added to the Mausoleum! ----------------------- ๐๐๐ฎ๐ฌ๐จ๐ฅ๐๐ฎ๐ฆ ๐๐ข๐ฌ๐๐ ๐ ---------------------- Adds The Visage into the Mausoleum boss pool with a weight of 1 The Gehenna Visage still exists, this mod merely adds it to the Mausoleum, too Contributors Silist and Kittenchilly Specia...4.9k downloadsupdated 2 y ago
- Fallen Angels spawn Imps, insteadby kittenchillySimply makes it so that Fallen Angels spawn Imps instead of the less fitting Angelic Babies.4.9k downloadsupdated 5 y ago
- Tweaked Lemon Mishap spriteby ViscerATweaked sprite for Lemon Mishap. Make sure to leave your feedback in the comments, and don't hesitate to recommend any other sprite tweaks you would like to see from me in the future! For your convenience, I'm uploading every sprite tweak separately, so that if you don't like some of them, . Afte...4.8k downloadsupdated 6 y ago
- Spindown Dice item previewby 76561198367165319Spindown Dice item preview I know there is already is Spindown Dice Preview (Reupload) but I made this spindown preview for myself, and sharing it there Features: multiplayer/co-op Car Battery Curese of Blind Shows next item only on full charge Doesn't show locked and hidden items (shows locked m...4.8k downloadsupdated 3 y ago
- Dynamic Minisaac Tearsby kittenchillyMinisaac's tears are now dynamic and have the same properties as your own tears! They can gain: - Your tear effects (piercing, poison, etc) - Your tear sprites and colors - Your range and shot speed - Your damage divided by 2 - Your fire rate All based on what items you have and how your own tear...4.8k downloadsupdated 3 y ago
- Baby Duke over Rotten Babyby 76561198350429877Resprites and renames Rotten Baby to be more like everyone's favorite floating fly dispenser! Includes a new name, description and textures (despite the youtube video showing no new name) Affects both the normal and Lil Delirium versions of rotten baby.4.8k downloadsupdated 4 y ago
- Blacksouls skin Portraits Modby 76561199529183539Added portraits that were previously missing from character skins and modified the main menu4.8k downloadsupdated 17 mo ago
- Rebalanced Tainted Lostby joshRebalances the items you can find as the Tainted Lost. Yes, this will make the character potentially easier. This does not change the actual quality value for items, so Bag of Crafting is unaffected. Does not change the chances of actually finding specific items (IE Holy Mantle is still around a...4.8k downloadsupdated 14 mo ago
- Flawless Boss Dropsby KadenThe game now rewards skillful players: when you defeat a boss without taking damage then you will get an extra Health Up item! โขAll of the HP Ups have been removed from the boss pool (this also includes items like Halo and Magic Mushroom). โขYou will always get atleast one item from beating a boss...4.8k downloadsupdated 6 y ago
- Start with D20by BarjuhStart each run with D20 Collection with all my Start with mods :4.8k downloadsupdated 3 y ago
- SCROTO MOD + (Boss Resprites n' Tweaks)by 76561198893672165Scroto's note: An update of a resprite mod I made in the past. Now implementing better resprites, new animations, new champions and new portraits! This mod requires REPENTOGON due to the custom VS screens of the final bosses. Special thanks to RATINSURACE for helping me with the code, to CY for h...4.8k downloadsupdated 2 y ago
- Mondongo Babyby TheCamrewNo hay mucho que explicar4.8k downloadsupdated 14 mo ago
- Mom's Foot Reminderby JujuI can't count how many runs I threw away by running into the boss room without thinking on floor 6. This mod fixed that. It will remind you that the upcoming boss fight is Mom's Foot. Whenever you stand next to Mom's Foot boss room, and your current room is cleared, you will hear mom screaming fr...4.8k downloadsupdated 3 y ago
- Enemy Blood Donations (RGON)by 76561198995475535This is an updated verison of the Enemy Blood Donations mod that uses Repentogon's amazing new features. The mod is nearly identical to the old version just now 100% more stable, completely lagless, and bug-free! This mod gives a lot more use to your temperance cards, allowing blood donation mach...4.8k downloadsupdated 22 mo ago
- Horsier Horse Pillsโขby SprSnpr_Say 'neigh' to boring horse pills! I've spruced up the horse pill sound effect with some equine nonsense.4.8k downloadsupdated 5 y ago
- Digglet parabiteby 76561198811060732We all know we hate this enemy, but instead of erasing them from the game, we might as well make them into something we love, so if you're a Pokemon fan, you'll know these adorable Digglet Pokemon.4.8k downloadsupdated 4 y ago
- I.S.A.A.Cby BarneyThe Intuitive System for Assisting in the Annihilation of Creatures! This mod adds a new active item to the treasure room pool that freezes enemies in their place, allowing you to select one to fire a volley of 5 of your tears. IF YOU'RE GETTING A BLACK SCREEN WHEN PLAYING THE GAME, TRY USING THE...4.8k downloadsupdated 4 y ago
- No Empty Chestsby โข Nato Potato โขVery simple. Removes empty chests from the room instantly, preventing them from getting in the way. (eternal chests get a count down timer to see if they reset or not before removing them) There are also the No Empty Pedestals and No Broken Machines mods. This is included in POTATO PACK 2.4.8k downloadsupdated 3 mo ago
- Character Trinketsby 76561198837246867What does this mod do? This mod gives every character a specific trinket to accompany them, they've been picked out to compliment their gameplay styles (without being too strong) and while visually fitting their colours/overall theming. Eden, T.Eden and Jacob/Esau are unchanged however. Eden/T.Ed...4.8k downloadsupdated 2 y ago
- Four Souls Fattiesby 76561199058109437Resprites Fatties and close relatives to be closer to the art shown on the four souls cards with some additions through artisitic liberty to some others that warranted a resprite as well. Changes: -Fatty -Pale Fatty -Conjoined Fatty -Flaming Fatty -The Fat Sack line Takes inspiration from HoneyVe...4.8k downloadsupdated 17 mo ago
- Reveal the Ultra Secret Room more!by kittenchillyThis mod adds new functionality to every item that reveals both the Secret and Super Secret Room by having them reveal the Ultra Secret Room as well! This effects Blue Map, The Mind, Ansuz, and Book of Secrets. Also, Dog Tooth now plays a sound of a dog whining if you are in a room that can lead...4.8k downloadsupdated 14 mo ago
- Strawman Drops Items on Death [REPENTOGON]by fly_6That would be hilarious, but this mod requires REPENTOGON mod to work! Too focused and not payed attention to the fact that your straw Keeper friend is on the verge of death but has already gone to the afterlife, and he was holding the most precious items you gave him? Don't worry! With this mod...4.8k downloadsupdated 23 mo ago
- Knife Piece Reminderby SenfjungeThis mod will remind you to get the Knife Pieces on the path to the new Mother boss. Whenever you enter a cleared boss room (or clear it) in Downpour/Dross/Mines/Ashpit II and don't have the corresponding Knife Piece in your inventory, it will play the Plum Flute sound effect and display a small...4.8k downloadsupdated 9 mo ago
- Drop/Swap Button Reworkedby 76561199032508689Have to keep holding CTRL for 5 seconds to drop trinkets or cards? Annoyed when playing as The Forgotten and have to press CTRL twice to swap active items? This mod allows you to drop your trinkets or cards faster by pressing only one button, and swap active by pressing the ALT key. By default Y...4.8k downloadsupdated 4 y ago
- God โฃโฃ Head on Start [REP / AB+]by AgentCuccoThis mod adds a new item to the game called "God โฃโฃ Head", it basically looks just like normal God Head but does nothing. This mod is a social experiment to see how much people actually download this mod without reading the description, thinking it will indeed give them God Head on start.4.8k downloadsupdated 8 y ago
- Four Souls Boom Fliesby 76561199058109437Resprites bomb flies and close relatives (save for repentance variants) to be closer to resembling their four souls card Changes: -Boom Fly and all of its variants, including familiars4.8k downloadsupdated 6 mo ago
- Restart Until Special Room With Tweaksby 76561199013014771Supports for Repentance/Repentance+! Original Mod: (Delete original mod to use it!) Slightly press R (Right Stick Button) to open config menu, again to close. UP and DOWN (A and y) to move selection, LEFT or RIGHT (X or B) to toggle. CTRL+R (Left Stick Button + Right Stick Button) to keep restart...4.7k downloadsupdated 21 mo ago
1.6k tweaks mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

