The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth tweaks mods
Everything filed under tweaks by its own author, ordered by how much it is used.
1,627 tweaks mods, most downloaded first · newest update 29 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
1.6k tweaks mods
- A little touch up to cards (resprite)by 76561198391425301A little resprite of some cards pickups. The joker resprite to Balatro is from here Although the og laughing joker is cool, it really doesn't work with so little sprite size. Here is a Compendium with all my resprites. PJJ's Resprite Compendium3.9k downloadsupdated 2 y ago
- Mama Mega Greed Mode Buffby kittenchillyMakes Mama Mega explode after every wave in Greed Mode! This gives the item a significant buff and more of a practical use in Greed Mode.3.9k downloadsupdated 5 y ago
- AwfulTweaks [RGON]by Mr. HeadcrabThis mod requires Be sure to follow the full install instructions on repentogon.com Are you sick of the standard, well-thought-out challenge mods out there? Have you found yourself wanting a mod made primarily for the enjoyment of anyone watching you play? This might be the mod for you! This mod...3.9k downloadsupdated 4 mo ago
- MORE detailed - The Stairwayby 76561199175201857Don't you think that the sprite of The Stairway is very simple compared to the others, besides containing a lot of black lines? This mod tries to fix that by modifying the sprite of The Stairway. Don't forget to leave your opinion in the comments and suggestions for other modifications, I will be...3.9k downloadsupdated 4 y ago
- [REP+] Always Map +by 76561199164471930Now compatible with mod config menu I was able to update this mod at the request of a comment to make it compatible with the Mod config menu. You can now decide which map effects are applied and customize them from the Mod config menu. Now the map, compass and blue map will not appear if an effec...3.9k downloadsupdated 2 y ago
- [Colored]Zodiac Items Into Constellations Respriteby 76561198452145624This is the colored version of Zodiac Items into Constellations resprite. More colors=BETTER. Enjoy! in case you want to check out the original version:3.9k downloadsupdated 10 mo ago
- Start Item Settingsby minishrek4This mod is based on the "Start Item Options" mod. it adds some settings to change what items spawn, and how many. options include how many items spawn. 0-28 how many items you can take. items that will always spawn. what item pools items are spawning from. min/max quality + more this is a WIP an...3.9k downloadsupdated 13 mo ago
- familiar overhaulby 76561198876704734I RELEASED A COOP BABY OVERHAUL MOD TO COMPLETE ALL THE CONJOINED FAMILIARS!!! GO DOWNLOAD IT!!! IT HAS 500 RESPRITES IN IT!! resprites like 90% of the familiars in the game, from brother bobby style conjoined familiars through sacks to all the bums. epic win sprites for boiled baby and juicy sac...3.9k downloadsupdated 7 mo ago
- Four Souls Big And Little Hornby 76561199058109437Resprites Little Horn and Big Horn into an appearance resembling that of the Big Horn Four Souls Card (I would have done both in their respective cards, however Little Horn did not have a card that looked similar to the Big Horn one) I spent like 5 hours on big horn alone ;-; Changes: -Big Horn -...3.9k downloadsupdated 17 mo ago
- (Better) HP Over Bossbar [REP+]by 76561198325350958Improved version of the "HP Over Bossbar" by Emperror - Support Mod Config Menu - Works with REP+ and below Changes: - Transparency Setting - Color Presets instead of RGB - Better Scale - Bug and Crash fixes Original mod:3.9k downloadsupdated 20 mo ago
- (REP) Modified Armorby ΘΔBig thanks to the author, hgrfff, for the original mod. ---------- Allows the scale of the in-game damage armor given to specific bosses and enemies to be freely modified. By default, this mod gives affected bosses a 30% damage scale, and removes the armor given to regular enemies. The full list...3.9k downloadsupdated 5 y ago
- Colostomia is now HAMPTERby 76561199017419812r u hate colostomia? wut about hampter? (this mod is sh1tty, and everyone knows that) PHASE 2 COME TO US😳3.9k downloadsupdated 5 y ago
- Your momby lesserStarTurns Mega Fatty into your mom (very ugly)3.9k downloadsupdated 6 y ago
- Tweaked My Reflection spriteby ViscerATweaked sprite for My Reflection. Now it actually resembles a cracked mirror! Well, at least I hope it does. Make sure to leave your feedback in the comments, and don't hesitate to recommend any other sprite tweaks you would like to see from me in the future! For your convenience, I'm uploading e...3.9k downloadsupdated 6 y ago
- Loki's cat earsby c:\re-sprite of loki's horns3.8k downloadsupdated 3 y ago
- [Ab+ Only] Bosses Eternal Edition+by GuilhermeTHIS MOD IS OUTDATED, Click Here FOR THE REPENTANCE VERSION This mod adds a new champion variant for all bosses, including final bosses, all based on the classic game. Eternal bosses are tougher and haves new mechanics and patterns. ATTENTION • This mod is included in Complete Eternal Edition+, d...3.8k downloadsupdated 4 y ago
- Sad Pickups SFXby SoundbinNow melodic pickups sounds are sad just like our good old friend Isaac :(3.8k downloadsupdated 2 y ago
- Tweaked Boomerang spriteby ViscerATweaked item sprite for Boomerang. Now it looks more like a boomerang, while keeping the original sprite's characteristics. Make sure to leave your feedback in the comments, and don't hesitate to recommend any other sprite tweaks you would like to see from me in the future! For your convenience,...3.8k downloadsupdated 6 y ago
- Quick SL(rewind)by 76561199194572216This mod allows you to quickly trigger console commands using the keyboard Backspace = "rewind" F4 = "spawn golden key" F5 = "spawn golden bomb" END = "debug 10"3.8k downloadsupdated 4 y ago
- Start with Holy lightby BarjuhStart each run with Holy light Collection with all my Start with mods :3.8k downloadsupdated 4 y ago
- +Lilith+by gan_regenI promise it's not a horny post, I'm too gay to do that to Lilith. Tried to heighten Lilith's fantasy by adding more items, then balancing it out a bit by reducing her health to 1 red and 1 black heart, and reducing her damage by 1.5 (or 0.75?? for some reason it's been changing on me as I make u...3.8k downloadsupdated 5 y ago
- tainted keeper start with birthrightby 76561198367122054Very simple. Tainted Keeper now starts with birthright.3.8k downloadsupdated 5 y ago
- [REP+ PATCH] Smart Invincibility for Self-Damageby 76561198823847927As of version 1.6, this mod is compatible with Repentance+, and no longer requires REPENTOGON. This mod removes the timing challenge from using self-damage slots while under timed invincibility (Book of Shadows, Chariot Card, etc). If your invincibility runs out while you are touching any vanilla...3.8k downloadsupdated 23 mo ago
- Bad Ice Cream Cube Babyby 76561198981246087Remember Bad Ice Cream? Now you can have the strawberry flavour as a companion while you struggle for life! also check out my other mod ^ ^ enjoy!3.8k downloadsupdated 2 y ago
- Fancy Locust Trinketsby EMORYShiny new sprites for the locust trinkets to make them more distinct3.8k downloadsupdated 4 y ago
- visible stompsby 76561198995475535Next up in the "visible" mod series, we got visible stomps! This mod makes it so that mom and satan's foot stomps are slightly translucent so you can see Isaac through them, because it's really annoying getting hit because they block a third of the screen. I genuinely don't know how this mod hasn...3.8k downloadsupdated 21 mo ago
- LFG Psy Fly Title Screenby SprSnpr_This mod is a combination of: BABY FUCKING PLUUUUM Psy Fly In Menu Please support the original mod creators and don't subscribe to this trash I've made (Grande if you're reading this I'm sorry lol) This mod was made by request3.8k downloadsupdated 5 y ago
- Tip Screen for Shopby 76561199105740664Shows an "add a tip" screen popup after buying a passive/active item in the shop (only in normal/hard mode, not greed/greedier). Purely cosmetic for a joke, doesn't affect gameplay (Although it does cover ~10% of your screen) This has only been tested in REP+/Repentance+ If you want the tipscreen...3.8k downloadsupdated 13 mo ago
- Start with Trisagionby BarjuhStart each run with Trisagion Collection with all my Start with mods :3.8k downloadsupdated 4 y ago
- Drop Button To Phase Through Pickups [Rework]by 76561199032508689Don't want to accidentally bump into an item or key? Mega chest in the way again? Holding the drop button lets you walk right through pickups. This is my reworked version of It basically works the same as the original mod, but with a few changes: Press 'V' on the keyboard to toggle walk through p...3.8k downloadsupdated 3 y ago
- [REP] No Cursesby MiyukkiMod removes all curses from game, it does not give Black Candle! Compatible with Repentance3.8k downloadsupdated 5 y ago
- Joker Duality Fix (+red chests, +teleport 2.0)by StlkngneIf you have Duality, the game doesn't let you choose between an angel or devil room when you use a Joker card. This mod will teleport you to a new room where you can choose. As an added bonus, red chests and Teleport 2.0 are also supported. This mod requires REPENTOGON.3.8k downloadsupdated 2 mo ago
- "Dog covering nose meme" SFXby 76561198324384778Changes the negative sound effect for consuming bad pills, losing on a slot machine or pressing buttons for the semi-popular "dog covering nose meme" audio. I hope you'll like it!3.8k downloadsupdated 4 y ago
- HP/Coin/Key/Item Perfect Start! Modby OnenessGives Full Health, 99 coins, 99 keys, 99 bombs and great items for every player (except Eden, Lost HP) including Apollyon!!! Items at start are: The Compass, Treasure Map, Blue Map, Spider Mod, Transcendence, PHD, and a Goat Head + more For a Perfect start! Note: if trying to use this with my Ite...3.8k downloadsupdated 10 y ago
- Antibirth for AB+ (and Repentance)by im_temDo not install this if you want to play Antibirth, go to antibirth dot com instead Antibirth was made by P.E.N.I.S team, not me or even better, get yourself Repentance instead of running this, dammit! ----- Antiborne is now real, even for Afterbirth+ (now also for Repentance!) Let's be honest, yo...3.8k downloadsupdated 4 y ago
- Tweaked Mom's Knifeby ViscerATweaked sprite for the legendary Mom's Knife. Make sure to leave your feedback in the comments, and don't hesitate to recommend any other sprite tweaks you would like to see from me in the future! For your convenience, I'm uploading every sprite tweak separately, so that if you don't like some of...3.8k downloadsupdated 6 y ago
- Drakob & Jesauby SlimesauceFrom the creator of Hushbob, I bring you Drakob and Jesau! I hate that Hushbob is my legacy now This mod was spawned from a conversation that I had with my friend in his car. I am not sorry. If this reaches front page again i am going to shit my pants and Die3.7k downloadsupdated 6 y ago
- Tweaked Blood Clot spriteby ViscerAIt's not just flipped sprite of Blood Clot. The thumbnail isn't 100% accurate, due to the updates I introduce after receiving feedback. You'll just need to subscribe to see how it looks :3 Make sure to leave your feedback in the comments, and don't hesitate to recommend any other sprite tweaks yo...3.7k downloadsupdated 6 y ago
- VVVVVV's Super Gravitron [Rep/Rep+/AB+]by JSGExpected an Isaac mod?....Late-March Fools!, it's VVVVVV's super gravitron but in Isaac. Ya, basically, just that, I remade an easier version of the VVVVVV's Super Gravitron as an AB+ mod challenge. How can I play it? Access the challenges menu and press tab, then look for "Super Gravitron". Make...3.7k downloadsupdated 4 y ago
- Evil Crawl Space Wall Be Gone!by Flap_JackFor anyone who has been frustrated by the infamous Repentance Crawl Space layout which has an extra item behind a wall, this mod simply removes the wall, so you don't need very specific items to access the extra item. This functionality is also in Rebirth of the Lamb by default, so there's no nee...3.7k downloadsupdated 5 y ago
- Librarby Doorby wrexy*Welcome to the library. *Yes, we know. *The sign is misspelled.3.7k downloadsupdated 4 y ago
- Diamond sword over spirit swordby 76561198372192441Mod changes all spirtes for spirit sword to diamond sword from minecraft (also some sound effects)!3.7k downloadsupdated 4 y ago
- Buggier Bugs [DISCONTINUED]by 76561198417302118A standalone version of the better flies and spiders from my other mod. Enjoy This mod changes the appearance of most of the fly and spider enemies to make them look a bit cleaner and overall better. Sprites currently used are made by Nioffe but i plan on replacing them with new ones in a future...3.7k downloadsupdated 5 y ago
- Energized! Transformationby edinAdds a new transformation, Energized! Acquire 3 battery related items(9 volt, The Battery, Charged Baby, Car Battery, Jumper Cables, 4.5 volt, Battery pack) to activate the transformation While you are Energized, all red heart pickups(except for rotten hearts) will be turned into batteries. Picki...3.7k downloadsupdated 5 y ago
- Pizza Beastby MADAOIt's PIZZA BEEEEEEEEEEEEEEEEEEEEEEAST!!!3.7k downloadsupdated 3 y ago
- Honeyvee's Resprites + Improved and Reworked Foes Compatibility!by 76561199022951369This mod adds compatibility for Honeyvee's Resprites and Improved and Reworked Foes so you can use them together, fixing any conflicting sprites. Also adds some other things that technically didn't conflict with the mod, but were added anyway for consistency. This mod affects; Soft Hosts (Red Har...3.7k downloadsupdated 13 d ago
- Integer Edenby O_oEden's Luck stat is now rounded up to the nearest whole number. Basically, Eden now starts with either 0.00 luck or 1.00 luck. Or, if you're really, really unlucky, -1.00 luck. "The decimals! They do nothing!"3.7k downloadsupdated 9 y ago
- Curse of The Based!by 76561198986475370Changes Curse of the Labyrinth into something more based. Pretty much it, enjoy your basedment adventures! Credit to Nyantuber for being based, and his discord for idea Sub or basedn't3.7k downloadsupdated 5 y ago
1.6k tweaks mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

