Mods / Active Items

• FFlashbackby QWiiKILL THE PAST - SAVE YOUR FUTURE Please put any bug reports in the discussion board called 'Bug Reports'! Have you ever died on a perfectly good run in a room with nothing in it that should've killed you? If you've played this game for any amount of time, the answer is probably yes. Enter Flashba...6.3k downloadsupdated 3 y ago
• TThe Boosting Of Isaacby MrMigglesBoost your Isaac run with 150+ different combinations of between 1 and 4 items at the start of each run! Designed to be a background mod while testing out other mods/characters, or if you just want to play an OP run, the items spawn on pedistals so you can decide which order or how many to pick u...6.3k downloadsupdated 10 y ago
• NNLSS Memes Itempackby DrakonnasAdds NLSS themed items to the game! So far this mod includes 43 all new items, 2 new trinkets and 2 new pill effects! Feedback / bug reports are always appreciated! If you want easy access to all new items, there's a variable called PREVIEW_ITEMS at the top of the main.lua file. Just turn that va...6.3k downloadsupdated 10 y ago
• AActives are Pocketed!by PermamissSets the active item of all characters to be a pocket item instead (if there is not already a pocket item for the character). Compatible with XML mods that change starting item Does not activate in Challenges Clicker/Ankh/etc. normally remove your pocket active; this mod gets around that issue Th...6.2k downloadsupdated 5 y ago
• AAaron's Custom Respritesby AaronRuinsLivesWhat is this? This mod is a collection of resprites made by me in my freetime because why not. It changes everything from items, pickups, UI, and even the title screen! If you have any issues or suggestions, or you want some help with some of your own projects, just DM me on Steam Important This...6.2k downloadsupdated 3 y ago
• MMerry Christmas Challengeby ☢ Nato Potato ☢Just something fun for Christmas. You start with Schoolbag and the Key Pieces. Your goal is to kill Mega Satan. (bonus points if you have the Mega Santa mod) All items that didn't come from a Mystery gift, including actives you dropped, are Mystery Gifts. (except for Polaroid and Negative, use th...6.2k downloadsupdated 22 mo ago
• RRunic Geodeby kittenchillyAdds the Runic Geode, a reusable rune (and soul stone) generator! Includes EID support, respects unlocks, and has actual Book of Virtues wisps! 100% compatible with any other mod that adds new runes or souls! Runic Geode - Active Charge: 6 Quality: 2 Item Pools: Treasure, Shop, Secret, Crane Game...6.2k downloadsupdated 5 y ago
• DD3by kittenchillyAdds a new dice, the D3! The D3 rerolls trinkets into other trinkets! Simple, but effective. Respects unlocks and can reroll into modded trinkets as well! Features EID support. D3 (Active) "Reroll trinkets" Charges: 3 Quality: 3 Pools: Treasure, Greed Shop, Crane Game Description: Rerolls trinket...6.2k downloadsupdated 5 y ago
• TTiny n' Cool Packby MerloHello there, and welcome to the "Tiny n' Cool" pack, presented by Merlo and Tritonis! Join our community Discord Server! The goal of this small pack is to incorporate some of the rather simple, yet fun ideas we see on the Binding of Isaac's Subreddit (plus some of our own), and incorporate them a...6.1k downloadsupdated 8 y ago
• FFancier Itemsby 76561199017158324Gives some items a fresher, fancier look. Im aiming to re-sprite more items, this is just the beginning!! currently changes these: the sad onion spoon bender blood of the martyr magic mushroom 1up mushroom lord of the pit brimstone ♥♥♥♥♥ of babylon spirit of the night abaddon deaths touch missing...6.1k downloadsupdated 7 d ago
• RRoad To Enlightenment [60+ Items/Trinkets/Consumables, 4 Characters!]by 76561199059921890Beaten, hurt, scarred, our tainted cast is given a chance at redemption. Granting them their most desired wish, God has passed them a second try at life. Their future holds either a worsened furtherance or a forgiven beginning. Follow them on their Road to Enlightenment as they make their way tow...6.1k downloadsupdated 12 d ago
• NNo More Breakfasting PLUS! [RGON]by Dr. JawatThis mod is a REPENTOGON-powered rewrite of "Im sick of multiple breakfasts!" by The__CJ and "No more Breakfasting!" by Maddogs. Tired of seeing BREAKFAST over and over at the end of a run? This mod hijacks true "Breakfast mode" and turns it into an actual item fiesta instead of a sad cereal loop...6.1k downloadsupdated 2 mo ago
• BBook of Genesisby nickTHE BOOK OF GENESIS Adam and Eve Type: Active Cooldown: 4 Effect: Summons a male and female familiar for the room. Pools: Treasure, Shop, Library, Angel The Book of Genesis is an active item that summons two familiars from a specific pool to fight for you until the end of the room. This can be es...6.1k downloadsupdated 10 y ago
• FFast IV bag, Portable Slot and Kamikaze!by ☢ Nato Potato ☢Very simple. The cool-downs for IV bag, Portable Slot Machine and Kamikaze! are drastically reduced, allowing you to use them more quickly, you can even just hold the button in and they will be used repeatedly. (it works without affecting the players damage cooldown so you will still be protected...6.1k downloadsupdated 6 y ago
• TTBoI: Radbirth [NUCLEAR THRONE]by majoThe Binding of Isaac: Radbirth is a mod that was made for Afterbirth in 2016 by majofps and EthanTheLion. Over the past week, it has been ported over and updated for the new DLC, Afterbirth+! Radbirth's Features: - ALL NEW Nuclear Throne characters - ALL NEW Challenges - Nuclear Throne themed ite...6.1k downloadsupdated 10 y ago
• AAero's Locust Expansion Modby 76561198881880834Important Note: Anybody new checking out this mod, I recommend you to download the Abyss++ mod instead of this one. Reasons why: Abyss++ has its content mostly finished. I don't have the motivation to finish the rest of this one. Abyss++ is based off of this mod, so you would be getting a similar...6.1k downloadsupdated 5 y ago
• LLoud Ni#ra Over Larynxby 76561198345921126Simple mod that replaces the Larynx scream with Loud Ni#ra. I cant make videos for this kind of stuff since my computer cant handle it, but Im sure you can imagine what it sounds like.6.0k downloadsupdated 5 y ago
• AAstra Mod 2.0by magicant tax collection agencyIntroducing Astra, a child from a distant world. Repentance support only. Update 2.0 - 17/10/22 The 2.0 update features a complete rewrite and partial redesign of the mod in order to make it less buggy, better looking and more fun to play. See the updates tab for the full list of changes. Adds tw...6.0k downloadsupdated 4 y ago
• FFixed Guaranteed Start [REP+]by 76561199054343421This is a fix/remake of the original Guaranteed Start. Any advice let me know! Features: - Replace the item ONLY in the first Treasure Room of the run *you go in* (that means u can skip for planetarium) with a 3 or more quality item. - It works with Greed Mode :D (read below) - Now it works with...6.0k downloadsupdated 4 mo ago
• TTBOI; Beyond - Repentant Incubuddiesby Ug-QualtothHello fellow isaakers, this is the Incubuddies Mod, now updated for Repetance!!! (or rather,, remade?! since all the sprites are brand new!! ahahah) SO, what does this mod do???!! Welp basically, every time u take an incubus, they will have the appearance of the character that you have! if u have...6.0k downloadsupdated 5 y ago
• MMario 1-1 In Isaac!by 『Sora』Adds Mario's first ever platforming adventure level to Isaac! This isn't a rom, it's Mario recreated using the base Isaac engine and physics. You can jump, shoot tears, bounce on enemies, collect mushrooms, and everything in between. Implemented as a separate character named Mario that you play as.6.0k downloadsupdated 5 y ago
• NNecromancer Costume(Rep+)by 76561198411462825When I looked through the newest patch notes, I saw a new transformation, and I said, "Where is it? Where is the new transformation costume?" but Edmun Mcmuffin preferred not giving it a costume, so this mod is for people like me who wanted a new costume for the new transformation in the game. Ha...6.0k downloadsupdated 14 mo ago
• MMisc item respriteby 76561199149887702A small mod that resprites a few random items, namely; Bob's rotten head delirious steven the poop mom's knife the inner eye lemon mishap ipecac dr. fetus and epic fetus torn photo head of the keeper proptosis and more?5.9k downloadsupdated 5 y ago
• MMama mega! is Warthog mind blown emojiby PEZMama mega! x warthog mind blown meme5.9k downloadsupdated 3 y ago
• BBone Daggerby ☢ Nato Potato ☢Using the Bone Dagger deals 1 red heart of damage and spawns 3-6 bone orbital familiars. This is included in POTATO PACK 1.5.9k downloadsupdated 7 y ago
• CCxRedix's Dice Respritesby CxRedixSimple mod that replaces all dice graphics to my own liking!5.9k downloadsupdated 12 mo ago
• CCard Printerby ☢ Nato Potato ☢The Card Printer allows you to turn spare active items into cards which retain their effects, basically you get a secondary active item like schoolbag, but it takes up a card slot instead of an active slot, doesn't need any charge and only works once. Just double-tap TAB (or whatever your map but...5.9k downloadsupdated 4 y ago
• CCar from Garn47 over Guppy (REP)by 76561198845546389Greetings! Nitrox here with my first steam mod! This mod aims to replace everything Guppy in Repentance with Car from Garn47. IMPORTANT: As of now, I do not know if this mod will work 100% on Repentance+. As much as I'd like to, it seems the way graphics and text displays work has been changed. S...5.9k downloadsupdated 2 y ago
• RRGBKey [REPENTOGON]by ImHer0MUST USE ANIMATED ITEMS AND REPENTOGONif you don't want to use the rest of Animated Items please disable them in the mod config menu 🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️🗣️ Use the Item or tap R while having the item for some switch sounds!!! 📢📢📢📢📢📢📢📢📢📢📢📢📢📢📢📢📢📢📢📢📢📢📢 The mod that turns the...5.9k downloadsupdated 3 y ago
• CCHAINSAW MANby 76561199155657668this mod changes berserk to chainsaw man and little chubby to pochita5.9k downloadsupdated 4 y ago
• BBoney Pawby ☢ Nato Potato ☢This skeletal variant of Guppy's Paw removes 1 red heart container in exchange for 2 bone hearts. It won't change your red health amount, so if you use it with a filled heart container you'll get 1 filled bone heart and 1 empty, use it on an empty heart container you'll get 2 empty bone hearts. I...5.9k downloadsupdated 8 y ago
• CCounter Cupby EstrogenGirl"Do deal with the devil." Coded by AstroPenguin642. Sprited by CatnipOverdose. This mod adds an active item to the game. It is based on the popular game that came out recently called Cuphead. Counter Cup "Projectile parry" - Press the spacebar while near a pink shot to parry it. - Parrying fills...5.8k downloadsupdated 9 y ago
• CConsistent Holy Beamsby padre ballHoly beams from Crack the Sky now look like the ones angels (Uriel and Gabriel) fire at you, and also like Revelation. Affects the following items: -Crack the Sky -White Pony -Breath of Life* -Holy Light It also works with the beams the Holy Eye enemy fires at you. *Doesn't change the four holy b...5.8k downloadsupdated 3 y ago
• TThe Serpent (+24 Unlocks)by Kerkel2 New Characters Have Appeared in the Basement! The Serpent aims to spice up the normal Isaac formula by making the player choose between 1 of 3 unique Blessings and 1 of 3 unique Sins upon starting a run. Blessings grant a modest benefit to help you along, and Sins provide a strong negative effe...5.8k downloadsupdated 3 mo ago
• LLootboxesby SwiftStriker00Introduction The intent is to provide players with a sense of pride and accomplishment for acquiring different items. As for cost, I selected initial values based upon data from the main game and other adjustments made to gate off rewards before launch. Among other things, I’m looking at average...5.8k downloadsupdated 9 y ago
• TThe Binding Of Nikoby 76561198925841301Explore new perspectives with Niko's mod! THIS MOD ONLY WORKS WITH REPENTANCE/REPENTANCE+!! The Binding of Niko brings the character of Niko from the video game Oneshot into a new world. The sun is a new active that makes Niko strong enough to defeat enemies. Featuring: 1 New character EID compab...5.8k downloadsupdated 9 mo ago
• OOguri Cap Judas Reskinby 76561199766476788Turns Judas into Oguri Cap from Umamusume Pretty Derby and Cinderella Gray. Includes many other theme variations: - Book of Belial turns into Tamamo Cross Plush; - The transformation induced by Tamamo Cross Plush and Devil Card turns the character into Oguri Cap's menacing shadow form from the an...5.7k downloadsupdated 6 mo ago
• HHit The Jackpotby MiemGPlays this legendary masterpiece of a song when you see a quality 4 item5.7k downloadsupdated 7 mo ago
• SSpindown D4by NeoDementThis item works exactly like the D4, except instead of randomizing the items held, it subtracts 1 from the items internal ID (just like the Spindown Dice)! This makes it very powerful, as you can roll into items from any pool. Because of this it's a Quality 4 item, just like the Spindown Dice. 6...5.7k downloadsupdated 5 y ago
• SShynova respritesby Shynova--Shynova Resprites-- This mod resprites over 50+ items, trinkets, and multiple enemies that you'll find in the game, updating their visuals to a dazzling degree! Any feedback and suggestions are welcome, and if you can, share this with your friends! :D -------------------------------------------...5.7k downloadsupdated 2 y ago
• PPLACENTA+by VerlyonDernière MàJ : 13.12.2019 : v1.1 Les voix ont été ajoutées automatiquement! Ce qu'il reste à faire : - Toutes les cartes "XXX appeared in the basement"; - Certains titres ne fonctionnent pas proprement au niveau des accents; - Quelques menus du départ, dont le bestiaire; - La voix de l'intro. Il...5.7k downloadsupdated 5 y ago
• [[BETA] Isaac Rebalancedby 76561198412573006Requires REPENTOGON! For more information, visit This mod is in BETA and is unfinished! Some bugs may be present! Isaac Rebalanced is a mod which changes many aspects of the game with the goal of making it feel more fair and fun to play. These aspects include... Item Changes Many useless and bori...5.7k downloadsupdated 2 y ago
• Sspongebob bible splash image repleacementby 76561199122079217Replaces the bible activation splash image with a blessed image of bob esponja #gangsterposting5.7k downloadsupdated 2 y ago
• [[REP/REP+]Glacier's Laboratoryby Red.16Just some random, wacky, and maybe unique stuff I make from time to time. Currently, the mod has: -4 characters -100+ items -20+ trinkets -13 pocket items -4 pills -Some new rooms Feel free to try it and leave a comment!5.7k downloadsupdated 8 d ago
• CCo-Op Commands!by MINDS3TThis mod adds a set of commands that allow you to add and remove items from any player currently in the game. The two commands: giveplayer (aliases givep, gplayer, gp) Usage: gp <player_id> <item_id> <count> Gives the specified player the item, count amount of times. item_id works with anything y...5.7k downloadsupdated 5 y ago
• WWater Bottleby ☢ Nato Potato ☢The Water Bottle is a 3 room charge active item that heals half a red heart and reduces tear rate by 25% for the current room. Quite useful in greed mode or with items that can increase your chage like habit, since then it can build up charge without you leaving the room and you can stack the eff...5.6k downloadsupdated 8 y ago
• LLiteral Item Namesby piece(REPENTANCE COMPATIBLE) Ever feel that your game is too unpredictable? Too exciting? Then literal item names is for you! In this mod, every item name relates to its visual appearance. No information means no ambiguity!5.5k downloadsupdated 4 y ago
• MMooniesby SpitefulFoxInspired by Edmund creating this game based on his childhood and working through his resentment towards just pulling inspiration from religious mysticism, I decided to make a mod. This mod adds items based on my overly religious childhood growing up in a cult. Adds five items and a trinket. You c...5.5k downloadsupdated 10 y ago

621 active items mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.