Mods / Active Items

• SSatoru Gojoby HoloSatoru Gojo Gojo is a brand new playable character for The Binding of Isaac. Start the game with the Infinite Void domain expansion and play as him to uncover his new unlockable items and more! The mod is still in beta and not all items have been added or completely finished yet. Gojo Stats: - St...25.4k downloadsupdated 3 y ago
• TThe Hostby [BA] mpolderCharacter: The Host This mod adds a playable character to your game called "The Host". The Host is a character based off the enemy "Host" which has similar abilities to this character. Items When this character is chosen the player will spawn in with 2 items. The first is The inner eye, which all...25.3k downloadsupdated 10 y ago
• [[RGON] Joseph The Cartomancer! (+12 Unlocks)by 76561198995475535It's in the Cards! Discover the secrets of the Arcana with Joseph the Cartomancer! Joseph is the master of the cards, and can enchant tarot cards onto himself to gain their effects permanantly, as long as he doesn't get hit! Whether you're starting a new save or already have dead god, you can enj...25.3k downloadsupdated 10 mo ago
• !!#Astrobirthby 허농이Astrobirth is a content mod derived from streamer OHY's 1vs1 time attack battles. Experience more thrilling moments with Isaac, including the following features! 150+ new items 30+ glowing planetarium items 10+ seems familiar characters 20+ distinctive trinket New machines that'll make your dopam...25.1k downloadsupdated 9 d ago
• [[ECO update] Eclipsed - betaby 76561198367165319Eclipsed ECO update Play as Nadab & Abihu - explosive brothers or as Unbidden - cosmic spirit Features: +4 characters +100 items +30 trinkets +80 consumables +9 challenges +16 curses +6 new beggars +40 unlocks Characters: 2 new characters with unique gameplay, as well as their tainted versions wi...25.1k downloadsupdated 2 mo ago
• RReady to Fire! - Active Item Charge Indicatorby 76561198986749186Ready to Fire! - Active Item Charge Indicator Ready to Fire! adds a dynamic fire indicator behind active items in the HUD, making it easy to see how close an active item is to being fully charged. As your active item charges, the flame grows larger and changes color depending on the charge type....25.0k downloadsupdated 3 mo ago
• CCadaver: The Rotten Expansionby LukanineCadaver is a mod for The Binding of Isaac: Repentance that adds 11 new unlocks, a playable character, and their tainted counterpart! Explore the basement with Cadaver, Isaac's rotting corpse, and gain access to Golden Souls, Rotten Chests, and more! CADAVER Cadaver only has one rotten eye, so he...25.0k downloadsupdated 3 y ago
• Lloadout[Fixed]by 76561198801593233This is an enhanced version of the Loadout mod originally created by Lyte. Compared with the original version: - Hold the navigation keys to scroll through items quickly instead of pressing them repeatedly. - The menu now scrolls row by row instead of switching entire pages. - Spawn the selected...24.7k downloadsupdated 2 mo ago
• AAngelaby AltzThis mod adds a new character named Angela. She is a holy apprentice on her way to becoming a true angel. Angela's path is littered with an unholy presence that could lure her towards evil doings. • 13 New Items! • 2 Transformations • Beggar Tweaks • Mechanics ITEMS • Angela Halo: +0.3 Speed • Ha...24.5k downloadsupdated 6 y ago
• PPlump Cutie Spider Butt!by VixieYoteMakes Spider Butt into a Quality 4 masterpiece ;3 Version 2.0! I made Mrs. Spider into an actual OC of mine, and now her name is Alyssa! I felt the need to update the mod with her new design. My second-ever mod is finally here, and with it, the first addition to my Plump Cuties collection! To be...24.1k downloadsupdated 12 mo ago
• UUse & Care Guideby SinstharUse & Care Guide is an active item with 4 charges, found in treasure room, that have 3 applications : - 1 : in a room with enemies, it spawn a microwave that will attract them and cook them to death. Please don't put metal inside... - 2 : in a room with a boss, a big fridge will fall from above,...24.0k downloadsupdated 10 y ago
• DDescripción de objetos Afterbirth+by juve_pc---External item descriptions in spanish--- Este es un Mod que muestra en la pantalla la descripción de: - Objetos (Items) - Píldoras - Cartas - Trinkets - Habitaciones especiales Los nombres de los objetos están en español e Inglés ya que lo configuré para que pueda funcionar a la par con el otr...23.8k downloadsupdated 6 y ago
• RRespritance+ (ultimate resprite pack)by 76561198871082898Currently only resprites few items from flash Isaac but ultimately this pack aims to resprite most of games items that are to stiff looking and don't fall in line with repentance's current artstyle Check out Isaac Rebalanced and Original Style Meat Boy and Bandage Girl If you ever wondered why is...23.6k downloadsupdated 14 mo ago
• BBeyondby ÉoleBeyond is a mod for The Binding of Isaac: Repentance that brings more than 60 items, 35 trinkets and 6 characters to the fray. The current version is 1.9! Most of the mod content is locked away behind 80+ achievements! The development of the mod is mostly over for now, unless I feel motivated aga...23.5k downloadsupdated 2 y ago
• [[RGON+] Arachna (25+ Unlocks!) | Update 2.0: Woven Anew!by rvstyBecome the lord of the spiders with Arachna - a new character, that revolves around web and spiders. Now back with full Repentance+ and REPENTOGON support! Arachna starts with a new item in her pocket active - Arachna's Spool. She can throw it at enemies to create web that slows them down and tur...23.4k downloadsupdated 4 mo ago
• 111 new items!by AlphiusThis mod adds 11 new items and 2 new trinkets. Here is a list of all the items added: Cursed D6 - "Reroll with caution" Cursed Box - "Solves all problems...?" Free Shipping - "Order online" Quatrefoil - "Lucky me" Life Insurance - "Good investment" Glyph of Consolation - "May you no longer suffer...23.0k downloadsupdated 9 y ago
• BBlackMarketby MaddogsIntroducing a new active item and passive item, Black Market and Rusty Scalpel! Because you didn't need those organs anyways, and a dollar is a dollar! Black Market Active item, 4 charges Upon use, Sells all heart pickups in the room to the devil for coins based upon their level, and sells any or...22.9k downloadsupdated 10 y ago
• LLuck Expandedby DevMaking this work in vanilla was quite a challenge and required some extremely hacky workarounds, but it's finally here. Repentogon is NOT required, though it is recommended for a small extra performance gain What does this mod do? The quality of pedestal items now scales with luck across all room...22.8k downloadsupdated 13 d ago
• PPocket actives on normal characters (Works on Co-op + clicker)by MothSets vanilla character's active items to be pocket actives (like tainted characters). Works on COOP Works with Clicker No longer conflicts with player.xml mods Thumbnail by Tarluk Mod showcase by SlayerXc2 Bug reports in the comments22.6k downloadsupdated 6 y ago
• AAnathema (Vitiated Characters) [RGON+]by 76561199012785050THIS MOD REQUIRES REPENTOGON TO WORK, IF YOU DON'T HAVE IT INSTALLED, PLEASE DO: (This mod is a complete overhaul of the (now unlisted) orignal "Anathema Mod", also known as "Vitiated Characters". Most aspects of this mod were touched up, reworked, or ditched entirely in favour of a greater, and...22.6k downloadsupdated 3 mo ago
• UUndertale Charactersby CakeThis mod adds the Binding of Undertale mod's characters to the base roster. Enjoy! This is not the complete mod: This is just the Characters, separate from the roster. If you want Backdrops, Bosses and more, check out the mod by clicking here! Spriting by Cake and Wight Characters include: Frisk,...22.5k downloadsupdated 2 y ago
• !!Rebirth Items Vectorized ! Redone!by EMORYRebirth Vectorized! replaces all item sprites with rasterized vector art similar to that of the original Flash game, but with vibrancy of Rebirth's sprites. New art for all of Isaac's items! Check out www.emoryillustrated.com/ for a gallery of all the artwork Mods that modify 005.100_collectible....22.4k downloadsupdated 3 y ago
• LLimbo Deals 2by The_Evil_PickleThis mod adds a third kind of deal room that can appear after boss fights: a Deal with the Old Gods (or Limbo deal for short). It won’t replace devil or angel deals - it appears when no other deal opens, or in rare cases alongside one of the other deals. Items in these rooms are free, and you can...22.2k downloadsupdated 4 y ago
• AAgnis - The Extracorporeal [Rep/Rep+/AB+]by JSGDisclaimer: this character is a challenge, Agnis is not OP (not supposed to!), it's complicated as hell, introduces mechanics that are new to the game and it's VERY hard to master...it falls in the same category as the lost or the keeper....if you dont want that kind of difficulty and are expecti...22.1k downloadsupdated 5 y ago
• PPOTATO PACK 2: Game Tweakersby ☢ Nato Potato ☢A collection of the mods I've made that modify the game mechanics, most of which are totally customizable using the Mod Config Menu. The pack includes: No Health Cap, No Pickup Cap, No Pocket Cap, No Curses, No Costumes, No Empty Pedestals, Custom Starting Items, Custom Base Stats, Custom Stat Ca...21.9k downloadsupdated 11 d ago
• PPandoraby RyouThis mod adds a new character called Pandora! She's had a hard life, be nice to her! Pandora starts with the active item Pandora's Jar, a damage multiplier of 1.2, a base speed of 1.3 but only has 2 hearts. When using Pandora's Jar, she will take damage in order to release some evil into the worl...21.8k downloadsupdated 6 y ago
• GGurzil - The Transmutator [Rep/Rep+/AB+]by JSGGurzil is a character that turns gridentities (Walls, Rocks, Vases, Skulls, Poop and Polyps of the womb) into turrets. There are limits tho: * He can only have 2 turrets of each kind at the same time on the same room. Items that add more tears increase this limit (Ex: Mutant spider increases the...21.7k downloadsupdated 5 y ago
• KKirby Mod! YOTF 2025 [RGON]by 76561198995475535No more cries! The pink eating boy makes the basement different forever! This mod adds Kirby as a playable character! You know Kirby, it's Kirby! He can swallow enemies and spit them out at other enemies! Complete with 14 unique copy abilities and a cool new form of attacking!! Crafted with love...21.6k downloadsupdated 16 mo ago
• SStackable Damocles | +Easy to use APIby AgentCuccoHaving multiple copies of Damocles will now spawn multiple items! Before, even if you had 50 copies, you would only get 1 extra item, but not anymore! It won't look as clean as regular Damocles, since I had to rewrite it from scratch, however it gets the job done, which is what matters :P This mo...21.3k downloadsupdated 4 y ago
• [[REUPLOAD] Aladar's Book Items Respriteby 76561198391425301Aladar, one of the, if not the best, spriter of Isaac has left internet, making his profile private and removing all the mods and amazing sprites and resprites he has done, sadly. I have a backup of most of the mods he had, and I'm reuploading them for the people who liked them, to still be able...21.3k downloadsupdated 13 mo ago
• TThe Punishedby Aevilok!!! Content Warning !!! This mod has recurring themes of trauma and abuse. Do not read further if those themes would make you uncomfortable. NOTE: The Tarnished Version requires Repentogon (and obviously the Epiphany mod). It also has a Repentance+ exclusive feature, but it's also made to work wi...21.3k downloadsupdated 6 mo ago
• EEdithby 76561198443814292UNFINISHED! BE WARNED - no birthrights + unfinished unlocks. hi im releasing the repentance version of edith publicly, because i know it will just never surface if i dont rip the bandaid off. its a brave new world for this character, so everything is subject to change. DO NOT EXPECT UPDATES.20.6k downloadsupdated 5 y ago
• TTainted Item Charge Soundby fartsox64Plays a sound when timed-charge pocket items for tainted characters, such as Judas and Jacob, have finished charging. This is an accessibility mod to help players with limited field of vision, as it's often difficult to see the outline around the items change when the item charges.20.4k downloadsupdated 5 y ago
• EEden's Soul and Star of Bethlehem Respriteby 76561198828705706Just a simple resprite mod of these 2 Items "Eden's Soul" and "Star of Bethlehem". May many people confuse them (including me lol) and just that... have a nice day... :) Esp: Solo un simple mod de resprite de estos 2 Items "Eden's Soul" y "Star of Bethlehem". Puede que muchas personas pueden conf...20.4k downloadsupdated 5 y ago
• IIssac missing poster itemby Vyro OneHi guys,have you ever wondered "I want to get the lost,but how the hell can I get the missing poster?" With this mod you guys are starting with the missing poster (with issac character ) and u can get the lost To enable the mod u need to enable the mod and disable all the mods u have. Steps: Step...20.3k downloadsupdated 9 y ago
• BBaphomet (22+ Unlocks)by 76561198411462825Now you can play as satanic symbolic figure! NOW WITH 24 UNLOCKS!!! List for Unlocks, items and trinkets: Or you can unlock all of the items by entering baphometgrandscheme to the console. List for some of the Synergies: Features: New dash ability with unique playstyle! New Rage ability! New Soun...20.2k downloadsupdated 17 mo ago
• [[Afterbirth+ Only]There's Way More Options at the Start!by dexAbout Repentance This mod won't work with Repentance, here's a Rep compatible version! No, it doesn't give you There's Options and More Options Tired of holding R, then running to the treasure room just to find a very underwhelming item? Well, this mod helps you getting a good starting item. What...20.2k downloadsupdated 6 y ago
• VVoid with divided chargeby GoganidzeVoid is now divided into two modes: item suck mode and active item use mode. Each of these modes has its own charge, which is filled together with each other. You can switch modes by pressing the drop button (CTRL or RB)19.9k downloadsupdated 22 mo ago
• HHappy Items Packby HaptyThis cool mod adds: - 4 exciting items - 1 scary familiar - 3 amusing trinkets ITEM SPOILERS: ep - all the amazing coding HappyHead - design and art19.8k downloadsupdated 9 y ago
• RRestored Collectionby 76561198374458982Relics thought to be lost have been found, and are now in the basement! Restored Collection is a collection items, pickups, and more, restored from Antibirth to Repentance, featuring 23 items and 1 trinket! Features 23 collectibles to discover, ranging from items cut from Antibirth to items based...19.7k downloadsupdated 1 mo ago
• AAle's Vocaloid (& More) Pack (on hiatus)by aleuni and work have been kicking my ass for an extended period, once i can breathe again i would love to contiune this. feel free to edit or upload assests from this mod (though pls mention me in the description or something idk). literally fighting for my life this past year... D': i decided to st...19.6k downloadsupdated 20 mo ago
• NNo Pop-up Animationsby msElboim7.17.21 Update: Some users report they can't sleep in a certain bed in one of the game's endings. I've tried it multiple times with different characters and can't reproduce it, so it could be beyond modding. If it happens to you, try unsubscribing from this mod, restarting the game and continue....19.4k downloadsupdated 6 y ago
• EEnhanced Item GFXby SauergesichtChanges a bunch of lame or too similiar GFX19.2k downloadsupdated 10 y ago
• [[Ultimate Sprite Collection]by ViscerAAt long last. It's been a fun ride! Now I'm gonna take a well deserved break, haha19.0k downloadsupdated 5 y ago
• [[REP] The Binding Of Pokemon + Legends Expansionby 76561198429240276A MOD MADE WITH A LOT OF LOVE AND AFFECTION BY FANS, AND FOR FANS. This mod is the official sequel to "The Binding of Pokemon" from Afterbirth+ now available for Repentance. Contains characters and items from "The Binding of Legends" (Rebirth) and lots of community-contributed Pokémon content. If...18.8k downloadsupdated 3 y ago
• FFirst Treasure Custom Qualityby 76561198395851613This mod lets you customize the minimum quality of items in the first treasure room The default value is 3 but using Mod Config Menu you can easily change it to whatever you want. You can also change if you want to get 2 custom quality items on curse of the labyrinth (XL). Note: - The mod will no...18.7k downloadsupdated 3 y ago
• EEven Playfield (items for monsters)by PixelPlzThe monsters learned to use items against you! Inspired by Risk of Rain 2, Even Playfield adds a unique way to spice up your runs. Each room gives your enemies a new set of items that affects them, including stat increases, new attacks, familiars and much more. Fight against wacky combos, take on...18.5k downloadsupdated 12 mo ago
• GGodby VideoGameNewsGod enters the depths below. This mod also turns off all costumes. Like my addon? Have any problems with it? Feel free to comment.18.5k downloadsupdated 10 y ago

621 active items mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.