Mods / Bosses

• CClothed Sirenby Rumpel TowardsAren't you tired of all those mods, that try to make Siren sexier, or fatter, or etc, etc...? Well, let's twist this formula ! Introducing: the Siren! WITH CLOTHES ON!!!!!! The Siren will now proudly wear rags she (stole) got from the Angels ! With a Seal of Approval Mausoleum Purple ! Yeah no, t...4.1k downloadsupdated 5 y ago
• !!!Last Judgement Resprites for Reworked Foesby 76561198387758985For use with Improved & Reworked Foes and Last Judgement Sprites This mod adds back the sprites from Last Judgement back to the enemies that had them overridden in Reworked Foes. Also adds new sprites for mod original variants. Not every enemy changed in Reworked Foes was edited, only the ones th...4.1k downloadsupdated 1 mo ago
• PPin With A Steel Chairby SlimesauceBY GAWD ITS PIN I dont think anyone's made this before so here it is also watch Sinvicta4.1k downloadsupdated 6 y ago
• MMy cat over Monstroby 76561199115858749Changes monstro into my cat Thomas Меняет Монстро на моего кота Томаса4.1k downloadsupdated 12 mo ago
• Tthe stain respriteby 76561198876704734resprites the stain commissions still open4.1k downloadsupdated 3 y ago
• Uultra greed but its markiplierby 76561198451802311This mod replaces Ultra greed with markiplier, that's it4.1k downloadsupdated 3 y ago
• GGangle over Mask of Infamyby 76561199569790089Hello everybody! Today im here again with my second mod. This time, i decided to turn the boss Mask of Infamy into the character Gangle from Digital Circus since well, the resemblance was quite there lol and i took the chance to do so Since the boss has a champion variant, i took that as an oport...4.1k downloadsupdated 22 mo ago
• CClassic It Livesby Haptychanges it lives to look similar to how it looked like in flash isaac4.0k downloadsupdated 9 y ago
• FFour Souls Enemiesby 76561199058109437This is a combination of all of my other Four Souls Enemy resprites in case you enjoy all of them and dont want all that clutter on your mod list! Changes a whole lotta sprites including every single fly enemy in the game4.0k downloadsupdated 2 mo ago
• IIncredible Gassy over Mega Fattyby 76561198338773226IT'S JUST GETTING STARTED! Gemmy retexture mod that will change boring Mega Fatty with the famous superhero Incredible Gassy. Includes: -Gassy Sprites -Champion variants -Gassy title card there is still no 'p embedded, don't worry chud.4.0k downloadsupdated 3 y ago
• MMAODIE over WIDOW (no music update)by JunkBroThis time I changed the cute boss "Widow" so that now he looks like a spider cat named MAODIE, the cat from the video on the bilibili platform, maybe you saw him in the funny scab videos posted on YouTube The mod changed the Widow sprite (also champion versions) and the transformation of the Dily...3.9k downloadsupdated 8 mo ago
• TThwomp High Preistessby 76561199590469868Changes mom and satan stomps and sfx into super mario 64 twomps3.9k downloadsupdated 2 y ago
• AAwfulTweaks [RGON]by Mr. HeadcrabThis mod requires Be sure to follow the full install instructions on repentogon.com Are you sick of the standard, well-thought-out challenge mods out there? Have you found yourself wanting a mod made primarily for the enjoyment of anyone watching you play? This might be the mod for you! This mod...3.9k downloadsupdated 4 mo ago
• FFour Souls Big And Little Hornby 76561199058109437Resprites Little Horn and Big Horn into an appearance resembling that of the Big Horn Four Souls Card (I would have done both in their respective cards, however Little Horn did not have a card that looked similar to the Big Horn one) I spent like 5 hours on big horn alone ;-; Changes: -Big Horn -...3.9k downloadsupdated 17 mo ago
• ((REP) Modified Armorby ΘΔBig thanks to the author, hgrfff, for the original mod. ---------- Allows the scale of the in-game damage armor given to specific bosses and enemies to be freely modified. By default, this mod gives affected bosses a 30% damage scale, and removes the armor given to regular enemies. The full list...3.9k downloadsupdated 5 y ago
• CColostomia is now HAMPTERby 76561199017419812r u hate colostomia? wut about hampter? (this mod is sh1tty, and everyone knows that) PHASE 2 COME TO US😳3.9k downloadsupdated 5 y ago
• YYour momby lesserStarTurns Mega Fatty into your mom (very ugly)3.9k downloadsupdated 6 y ago
• [[Ab+ Only] Bosses Eternal Edition+by GuilhermeTHIS MOD IS OUTDATED, Click Here FOR THE REPENTANCE VERSION This mod adds a new champion variant for all bosses, including final bosses, all based on the classic game. Eternal bosses are tougher and haves new mechanics and patterns. ATTENTION • This mod is included in Complete Eternal Edition+, d...3.8k downloadsupdated 4 y ago
• DDank Lust (a lust variant)by Guilhermethis mod add a variant to lust and super lust the normal lust just chase the player the dank lust creates black creep and spawn spiders he have 25% of chance to replace lust3.8k downloadsupdated 3 y ago
• MMom's Huntdownby BoogsMom got really hecking tired of waiting and decided to fight her herself and beat isaac like a gosh darn adult. Play with too many Magic Mushrooms and an attempt to make this fun, Treasure rooms are allowed! Go crazy! Challenge goes to Isaac on normal difficulty. Tested on both difficulties and won.3.8k downloadsupdated 10 y ago
• Tthose who know dogma [REP/REP+]by 76561198438161524changes that one frame of the Dogma troll face to the "those who know" troll face yes this is satire * note that this will only appear once Dogma is low HP because of how the boss is coded those who know: 💀💀3.8k downloadsupdated 21 mo ago
• SSuper Sloth Makes Green Creepby Guilherme3.8k downloadsupdated 6 y ago
• HHandsome Jermaby IndefixChanges Mom Shadow to Handsome Jerma run3.8k downloadsupdated 3 y ago
• 110 cards packby 7656119880340664810 new cards have appeared in the basement! ·This mod adds 10 new cards with new effects to the game! Cards list: - God card *Effects: It has a 95% chance of giving you a coin and a 5% chance of giving you godhead *Spawn chance: 0.5% - Mirror card *Effects: Changes all your items (like D4) *Spawn...3.8k downloadsupdated 7 y ago
• AAntibirth for AB+ (and Repentance)by im_temDo not install this if you want to play Antibirth, go to antibirth dot com instead Antibirth was made by P.E.N.I.S team, not me or even better, get yourself Repentance instead of running this, dammit! ----- Antiborne is now real, even for Afterbirth+ (now also for Repentance!) Let's be honest, yo...3.8k downloadsupdated 4 y ago
• TThe Messengerby The_Evil_PickleAdds a new boss: The Messenger! The Messenger is a mechanical boss that can appear in the early floors. The fight is centered around four TV screens on the walls. The boss can only be damaged by shooting a screen that displays a color or pattern matching the large central structure. The Messenger...3.7k downloadsupdated 6 y ago
• AAnimated Duke Wingsby wesIncludes Delirium and Delirious! Inspired by Weather's mod, Duke with Wings. Check it out here:3.7k downloadsupdated 4 y ago
• MMr. Bright and Mr. Shine Bossesby GuilhermeA duo of bosses appears in isaac, now from kirby there's: Mr. Bright and Mr. Shine. UPDATE: there's a modpack containing all of my bosses now, check it here: They can be found in the Depths and Necropolis. It has it's own music from the original game (you can disable it if you don't want with the...3.7k downloadsupdated 3 y ago
• PPizza Beastby MADAOIt's PIZZA BEEEEEEEEEEEEEEEEEEEEEEAST!!!3.7k downloadsupdated 3 y ago
• HHoneyvee's Resprites + Improved and Reworked Foes Compatibility!by 76561199022951369This mod adds compatibility for Honeyvee's Resprites and Improved and Reworked Foes so you can use them together, fixing any conflicting sprites. Also adds some other things that technically didn't conflict with the mod, but were added anyway for consistency. This mod affects; Soft Hosts (Red Har...3.7k downloadsupdated 13 d ago
• FFightable Mother's Shadowby catinsuranceRequires REPENTOGON For more information, visit FIGHTABLE MOTHER'S SHADOW Ever thought the Mines escape sequence for Knife Piece 2 was too long or tedious? Or maybe, you just wanted to shake up the experience after going alt path every time? This mod turns Mother's Shadow into a boss fight. Defea...3.7k downloadsupdated 12 d ago
• TTurdlet Roblox man faceby 76561198376947023So, I replaced the turdlet boss face with a roblox man faсe. And that's what happened. Changes: -Turdlet is now "Roblox Turdlet" -Turdlet's face replaced to man face -"Vs" is now red -Added a vid from Helkros (thank u veri much)3.7k downloadsupdated 4 y ago
• BBoss Rushby Oscarfcb4----------------------------------------------------------------------------------------------------- Boss Nightmare! No enemies, only bosses. To hard for you? No worries, in every floor (and in the first treasure room) you'll get two extra items. Good luck! The mod kill all enemies in rooms and...3.7k downloadsupdated 5 y ago
• TThe Binding of Pokimon Mystery Dungeon [Afterbith + Edition]by NarxThe Binding Of Pokimon Mystery Dungeon is a mod that turns Isaac's basement into pokemon mystery dungeon world, includes PMD levels, bosses soundtrack sound effects and much more... DOWNLOAD FULL VERSION HERE: mega. nz/file/yhEADZpa#X9R9MN2_tNITsbixkOxlmknccSU1cBjsD5GEUmaVbwI FEATURES: -Playable...3.6k downloadsupdated 6 y ago
• [[Ab+ Only] Bugfixes and Improvementsby GuilhermeThis mod is a compilation of my bugfixes and improvements mods, it has a low priority so any mod should overwrite it, maximum compatibility! All following mods are already included in this mod, don't subscribe to them! (Bug fixes) Fixed Bandage Girl Body Fixed Peep/Bloat's eye hitbox Fixed 1 Boss...3.6k downloadsupdated 6 y ago
• BBROTHERby HengusMA complete reskin of the Mother boss fight, but INSTEAD OF GETTING YOUR ASS KICKED BY A STUPID DUMB BOSS THAT RESEMBLES YOUR MOM, YOU'RE GETTING YOUR ASS KICKED BY THE HULKSTER HIMSELF, BRRRROTHERRRRR! OOOOOH, YEAH, BROTHER! WE'RE GONNA THROW DOWN IN YOUR MOTHER'S CORPSE, BROTHER! WHY AM I HERE?...3.6k downloadsupdated 5 y ago
• PPog Plum Titleby SprSnpr_The newest iteration of memes making their way into the game via community-made nonsense. Heavily inspired by the "POG for Good Items" mod, which can be found here:3.6k downloadsupdated 5 y ago
• LLost-Signal Dogmaby Somebody ObsoleteChanges Dogma from Static to a No TV Signal Image I found, that's it. The Dogma Brimstone looks shoddy, but I can't be bothered to fix it. Should come with the No-Signal image itself in multiple sizes, as well as a txt document for the hue/saturation/brightness shading, that is if it got uploaded...3.6k downloadsupdated 4 y ago
• SSteven is Spamtonby 76561198791998370This mod replaces the boss Steven with Spamton. The Item pool as been resprited as well with a Spamton familiar and a PIPIS3.6k downloadsupdated 5 y ago
• FFake isaacby MADAOOh my God, it's fake Isaac from Pizza Tower3.5k downloadsupdated 4 y ago
• BBaby Plum to :plumagony:by Mr. HeadcrabChanges Baby Plum to look like the emote :plumagony: Also edits Fruity Plum and Plum Flute and it's sound effect3.5k downloadsupdated 14 mo ago
• TThomas The Trainby 76561199012901506I thought it would be a good idea to replace Larry jr whit Thomas the train I hope you enjoy it!3.5k downloadsupdated 5 y ago
• MMonstro's S#!t-Eating Grinby AuldYou know that single frame of animation right before Monstro uses his barf attack? In the original Binding of Isaac, it was this amazing s**t-eating smirk, like "f**k you and f**k your parents." Unfortunately, that didn't really translate into the remake, so I edited it to look more like the orig...3.5k downloadsupdated 5 y ago

475 bosses mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.