Mods / Bosses

• DDevil Keysby 76561198995475535Since Repentance released, Angel rooms have become the new meta, with most players opting to skip devil deals entirely for better and cheaper angel items. When going for Mega Satan especially, devil deals are often ignored completely to even get a half decent chance at getting both angel key piec...50.5k downloadsupdated 4 y ago
• UUnique Isaac Boss Fightby 76561198810574085Changes Isaac(boss) sprites, based on player character. Currently there are only 17 sprites for regular characters, and if you play as tainted character you will be fighting a normal version of your character49.8k downloadsupdated 5 y ago
• LLast Judgementby GuwahavelThis is 1 portion of the mod, which only has the new content. The resprites and vanilla tweaks are in here. Last Judgement is a major content mod which aims to restore thoughts, ideas, and concepts that were proposed during the development of the official Binding of Isaac: Repentance DLC. Ideas w...48.4k downloadsupdated 1 mo ago
• DDogma BLYAAAAAAAAby 76561198369844905Changes Dogma appear sound to Russian kid screams BLYAAAAAAAAAAAAAaAaaaAAAAaaaa bcz his minecraft house disappears meme Saw this video from channel taki_ and thought that it should be a mod. I'm streaming on Twitch btw~ You might aswell like my other mods for Isaac48.0k downloadsupdated 5 y ago
• AAlt path in Greed Modeby 76561198376008952Fully playable alt path for Greed Mode! In the base game, you can play with those floors via the debug console but boss waves and entire Gehenna and Corpse floors are missing. So I added the missing boss waves and 120 different waves for Gehenna and Corpse! I tried to copy the style of the other...47.2k downloadsupdated 3 y ago
• TThe Beast Laughs When You Take Damageby GuilhermeThe beast laughing is an animation that is fully present in the game but for some reason is never used, so this mod makes the beast do that animation when the player takes damage46.2k downloadsupdated 5 y ago
• TThe Dark One Mod (reupload)by Sauce F. NaughtPlease remain calm, this is just a simple reskin mod. Nothing bad here... Enjoy! ^-^45.9k downloadsupdated 4 y ago
• FFall from Grace (Boiler and Grotto)by GuwahavelDo you have what it takes to stay afloat in the Boiler and the Grotto? Fall from Grace is a floor expansion mod which adds alternative floors which can appear when traveling through the floors added in the Repentance DLC (the Mother path). Boiler is a hot and steamy alternative to the Downpour! G...45.9k downloadsupdated 2 y ago
• FFancy Boss HP Bar (Plus Edition!)by BaicherraImagine that boss health bar dignity as well as your big enemy *Plus Edition new features -Support for Afterbirth+, Repentance and Repentance+ -A brand new small variation of skelly bar for Repentance(+) players -Sneaky various configurations to play around with (with manual FBB_config.lua editin...44.7k downloadsupdated 12 mo ago
• TThe Binding of Isaac: The Devil's Harvestby TeamPROBIRTHIntroducing The Binding of Isaac: The Devil's Harvest MOD. Made by a team of elite The Binding of Isaac: Afterbirth+ modders named Team Probirth, this total conversion expansion mod is guaranteed to shake up the now stale meta of Isaac franchise forever by introducing wacky new groundbreaking con...43.4k downloadsupdated 10 y ago
• AA Rotey Packby rotexorA mod with tons of graphical changes, with minimal changes to non-boss enemies. I decided for the sake of cleaning up my mods folder, and not having lots of the same files fighting over which image to flop down, I'd make a pack featuring graphical changes that I like, and merging most of the shar...43.1k downloadsupdated 1 mo ago
• TThe Beast but it's My Dadby unfunny username #1967Hey, It's exam season for me and instead of studying for the exam I have this Friday I decided to do this, my magnum opus. I'd like to see any of you mfs top this one. Heavily inspired by this mod right here: GUYS THIS GOT PLAYED BY ALBINO ON HIS STREAM, MASSIVE FUCKING WIN. @ 2:37:4343.0k downloadsupdated 5 y ago
• [[REP] Русификатор TBoI [УСТАРЕВШИЙ]by NeibernОписание: Подарок от сообщества на 10ти летие Айзека, да и собственно сами Nicalis в скором времени сделают нам подарок ;) Русификатор основан на переводе Русской Вики по игре. По всем вопросам и предложениям писать в специальные обсуждения. Что на данный момент переведено: - Меню - Предметы - Бо...42.2k downloadsupdated 5 y ago
• SSatanic Replacementsby 76561198372132417What does this mod do? It replaces some sprites from bosses and items, while also changing their names and pictures on VS screen. Please note that I do not own most of this mod's content, credits and changes will be listed below. Changes List of changes made, I would recommend unninstalling any o...41.8k downloadsupdated 3 y ago
• BBestia on Dead Godby 76561198802955004A simple mod that replaces the Beast with Bestia on Dead God achievement list and save drawing. This is a reupload after the recent Steam ban, so... God is finally DEAD41.8k downloadsupdated 16 mo ago
• AAlt Horsemen (COMPLETE)by hippocrunchyThis mod adds a completely new set of harbingers for the alternate path! Also comes with a unique (stronger) cube of meat variant. Requires Custom Stage API get it -> here ----------------------------------------- Harbinger Hitlist Famine (Downpour/Dross) ✓ War (Mines/Ashpit) ✓ Death (Mausoleum/G...39.7k downloadsupdated 4 mo ago
• AAddie Modby Sauce F. NaughtA Reskin Mod for The Adversary.39.5k downloadsupdated 4 y ago
• NNotYourSag's Sirenby EMORYGives Siren the appearnace that NotYOurSagittarius draws her in. Comfy sweater. Art by NY_Sagittarius Red Hair Variant: Isaac Character Portrait from this mod:38.7k downloadsupdated 5 y ago
• HHeaven's Call [Solar Update](RGON)by UltrinikDO NOT HAVE INSTALLED OLD HEAVEN'S CALL VERSION!!! THIS MOD REQUIRES TO FUNCTION Check Isaac Guru's page for more detailed information Follow Heaven's Call on Twitter Mirror download for manual installation Play Heaven's Call Suika 13 new boss battles await your challenge! 1 FINAL BOSS! 10 Challe...37.8k downloadsupdated 14 mo ago
• SSimple Boss APIby DeadInfinityBoss API that will be / is necessary to play my boss mods. Essentially a set of functions to assist in development of bosses, whether that be boss ai or boss pools. I'm moving it to an independent mod so that I don't have to keep up to date several separate versions of one very similar api, and s...37.6k downloadsupdated 9 y ago
• UUnique Sins (rep)by jeckjedUnique sprites for sins, based on current background • Original (with some touches here and there) for Basement, Mega Satan, and any Unfinished places • Infested - Cellar • Burnt - Burning Basement • Fungal - Caves • Stone - Catacombs • Drowned - Flooded Caves • Pale - Depths • Ghost - Necropolis...37.3k downloadsupdated 19 mo ago
• LLost and Forgottenby ENFOR!!! Lost and Forgotten requires Stage API to work properly !!! !!! Repentogon is NOT required but it's highly recomended !!! This mod is a Repentance port of the original Lost and Forgotten for Afterbirth+ with double the amount of features, improved art and performance. o Features o 100+ items 2...36.8k downloadsupdated 16 mo ago
• HHell&Heaven Taker!by 76561198994190923天使和恶魔boss主题的娘化 精神错乱版本已更新 包括： -洛基 Loki -分身洛基 Lokii -堕落恶魔 The Fallen -坎卜斯 Krampus -撒但 Satan -黑暗恶魔 Dark One -敌手 The Adversary -超级撒但 Mega Satan -小角恶魔 Little Horn -巨角恶魔 Big Horn -岩角恶魔 Hornfel -加百列 Gabriel -乌列 Uriel -堕落加百列 Fallen Uriel -堕落乌列 Fallen Gabriel -羔羊 The Lamb -魔角兄弟 Horny Boys36.6k downloadsupdated 3 y ago
• BBoss Butch! (13 new bosses)by PixelPlzBoss Butch adds 13 brand new bosses to kick your ass in unique and surprising ways! If that's not enough for you, then you can also test your might in the Boss Butch challenge, featuring all of the new bosses! Also included is a special Boss Butch Bestiary™, where you can learn more about your fa...35.6k downloadsupdated 4 mo ago
• HHush Now Drops Eden's Blessingby ErwanHush Now Drops Eden's Blessing You don't have enough reasons to go for Hush? You think it's a waste of time and not rewarding enough? Well, now it's time to destroy him again! With this mod, if you already unlocked the item, Hush now drops the amazing item Eden's Blessing when you kill him! A goo...35.5k downloadsupdated 4 mo ago
• CCrewmate Plumby ThothdjMakes Baby Plum a bit sus. Comes with Fruity Plum, Baby Plum, Boss Image and Delirium forms.35.3k downloadsupdated 5 y ago
• BBestia with no background bugby 76561199114372572Ever wanted to replace The Beast with a waifu demon mommy with big demon milfy mommy milkers? No? Oh. This isn't for you then. "Bestia" is a mod that replaces The Beast with a big jiggly milf demon that I spent 41 hours modding into the game. The mod that took r/bindingofisaac by storm over the l...35.0k downloadsupdated 14 mo ago
• [[RGON] Arknights : Terra, a Journeyby 76561198976289600Arknights : Terra, a Journey A crossover content mod inspired by Arknights, bringing new mechanics, encounters, and Terra-flavored content into The Binding of Isaac. Requires Repentogon to play! Arknights : Terra, a Journey is a content-rich mod that introduces original items, trinkets, enemies,...34.5k downloadsupdated 12 d ago
• TThe Gardenby Doug Bowen== Features == For answers to common questions, please see the FAQs and Known Issues under the Discussions Tab * New room: The Garden * 13 new passive items! * New challenge: Genesis * New curse: Curse of Mortality * New bosses: The Serpents * New transformation: Deceiver! * New music * New sound...34.0k downloadsupdated 10 y ago
• SSenator Greedstrong modby LEFRUTITINew way to experience greed game mode! Checkout "Senator Greedstrong mod" you will get: gorgeous ultra greed resprite, new ultra greed sound effects and new background music! Mod сompatibility HardMode Major Boss Patterns Enhanced Boss Bars33.3k downloadsupdated 5 y ago
• AAlwaysHUSHby Coco Poops®allows the player to go to the hush no matter what the time is33.1k downloadsupdated 6 y ago
• ZZombie Modeby SoonsOutWelcome to Isaac Zombie, a whole new game mode ANYONE EXPERIENCING IMMORTAL ZOMBIES TRY DISABLING ALL OTHER MODS. SHOULD FIX xoxo <3 IT IS RECOMMENDED TO DISABLE ALL MODS WHEN PLAYING!!! Some bugs like infinity zombies may occur when other mods are enabled. And infinity zombies are always bad HOW...32.9k downloadsupdated 10 y ago
• QQuarryby MaddogsDuring one of your escapes from your mother, you accidentally stumbled into an area left abandoned years ago, a part of the caves long forgotten and left to fester... but you're not the only one. Enter The Quarry, an expansion onto the Caves/Catacombs floors! Living gemstones, rocks rich with gol...32.1k downloadsupdated 8 y ago
• PPlump Cutie Min-Min!by VixieYoteShe's a lil cutie! I've always liked Min-Min and was pretty disappointed to see a lack of cute replacers for them, so I decided to make one of my own! This is my first Isaac mod, so there's bound to be something wrong with it, so I'm just gonna hope for the best :v I do want to note, as this is m...31.5k downloadsupdated 21 mo ago
• SSubnames Simpleby Loud & NoisySimple little flares for the Versus screen. Most Bosses and Characters now have little flavor text on their names, Thematic Callbacks and funny refrences galore! Credits: - Loud & Noisy: Original creator, advisor, RB/Rep namer, co-artist, and publisher. - Robby Shenanigans: 2nd Torch Barer,AB+/Re...31.5k downloadsupdated 4 y ago
• RRepentance Eternal Editionby GuilhermeEternal champions, now for Repentance! New champion variant for all bosses and monsters, reworked final bosses, new ambush room variant, all inspired by the classic game What's new: • Click here to view the full documentation of this mod • Rebalances are disabled by default, enable it for a harde...31.4k downloadsupdated 4 mo ago
• BBumbarioby HengusMEver thought to yourself, "Gee, Bumbino's charge attack looks an awful lot like Wario's, huh?" No? Just me? Well, introducing Bumbario! The new, REVAMPED version of Bumbino! It features some of Wario's classic characteristics, suave mustache, voice and hat! FEATURES: *New sprites *Smashingly good...31.4k downloadsupdated 5 y ago
• KKing Baby to Little Sirenby 76561198324517311Just a little mod that reskins King Baby into Little Siren! She charms your familiars just like the real one and makes them attack the nearest enemy. It's so obvious, I wonder why nobody did this earlier? Unfortunately, i couldn't add any sound effects or even change the item name (the new transl...31.3k downloadsupdated 5 y ago
• HHush respriteby 76561199149887702Revisit the blue womb and face off against hush and his armada in a fresh coat of paint, soldifying him in isaac's rogue's gallery even more. Hushy is there too special thanks to Randomroyal and Mrfirework for helping me get this mod out (and fixed) (reuploaded due to a misclick and the entire mo...31.1k downloadsupdated 5 y ago
• SStarFall | 35+ Unlocks & More!by 76561198447262219Shooting stars can make a wish, right? Just imagine how a Starfall can make us all happy... 2 new characters 46 new collectible items 20 new trinkets 4 new consumables 2 new hearts 1 new chest type 2 new challenges (With unlockables!) 1 new monster 40 new rooms Tons of synergies! Stay tuned to se...31.0k downloadsupdated 3 y ago
• BBinding of Undertale+Deltarune [Standalone]by CakeThis is a standalone version of the Binding of Undertale + Deltarune Mod! It contains replacements for items, floors, bosses and music, and adds Undertale/Deltarune characters to the roster, on top of existing characters. Enjoy! =============================== ATTENTION: After installing: Open yo...30.9k downloadsupdated 4 y ago
• BBoss Meme Resprite - Little Sussyby FerpeResprited and reanimated Little Horn to be sussy among us!!!!!! Includes its champion and Delirium versions! This one's dedicated to my friend Hilarious February (he's not dead he's just british) This is directly inspired by the mod "little horn is sussy" by Elequi12:30.7k downloadsupdated 4 y ago
• SSO_MANY_CATSby 76561199091925974VERSION THAT ONLY CHANGES SHOPKEEPERS: All shopkeepers turn into cat gifs All special shopkeepers get a golden tint and effect Angel and devil statue changed (and the satan fight) Mega Satan is that weird lookin cat30.6k downloadsupdated 2 y ago
• AAlwaysBossRushby Coco Poops®allows the player to go to the boss rush no matter what the time is29.9k downloadsupdated 6 y ago
• SSteel Ball Run Repetanceby Bagre☆Hi, I made this mod based on Steel Ball Run Steel Ball Run Character Pack Now updated for full Repentance compatibility, i guess. He starts with 3 coins and a single bomb He's accompanied by Gyro and Tusk He shoots fingernails and his friend Gyro's got the steel balls And Funny Valentine and Dirt...29.8k downloadsupdated 4 mo ago
• GGodmode Achieved [[[BETA]]] [REP] [RGON optional] devby MINDS3TJoin the official community/development discord! Check out the official wiki! So far: A new final boss and stage!! Test your luck against this beast of a battle.. (also, unlock Godmode items!) 500+ brand new, unique treasure room layouts. This is clustered into types of treasure rooms, each havin...29.7k downloadsupdated 13 d ago
• TThe Ritualby SinstharThe Ritual is a random event that can appear (or not) during your journey downstairs. This mod is the new version of the Invocation Circle, which are now unavailable (to prevent some bugs with the new version). The mecanics have changed, so I decided to release a new mod. How does it work ? - Fir...29.4k downloadsupdated 5 y ago
• CCHANGE SIREN INTO MIKUby 76561198816620673把塞壬的贴图改为初音未来！ 添加了のもの脸、油库里、｀Д´脸和亚种钢音 以后可能改变塞壬的音效29.3k downloadsupdated 5 y ago

475 bosses mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.