The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth enemies mods
Everything filed under enemies by its own author, ordered by how much it is used.
359 enemies mods, most downloaded first · newest update 26 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
359 enemies mods
- A Rotey Packby rotexorA mod with tons of graphical changes, with minimal changes to non-boss enemies. I decided for the sake of cleaning up my mods folder, and not having lots of the same files fighting over which image to flop down, I'd make a pack featuring graphical changes that I like, and merging most of the shar...43.1k downloadsupdated 1 mo ago
- [REP] Русификатор TBoI [УСТАРЕВШИЙ]by NeibernОписание: Подарок от сообщества на 10ти летие Айзека, да и собственно сами Nicalis в скором времени сделают нам подарок ;) Русификатор основан на переводе Русской Вики по игре. По всем вопросам и предложениям писать в специальные обсуждения. Что на данный момент переведено: - Меню - Предметы - Бо...42.2k downloadsupdated 5 y ago
- Melisby MaddogsPlay as Melis the Succubus, a demon with the ability to consume the souls of those she charms. You will start with flight and spectral tears, however you cannot shoot, as she has 4 other mechanics to play with: - A demonic aura that damages all enemies inside it and increases with Melis' range an...41.7k downloadsupdated 10 y ago
- Alt Horsemen (COMPLETE)by hippocrunchyThis mod adds a completely new set of harbingers for the alternate path! Also comes with a unique (stronger) cube of meat variant. Requires Custom Stage API get it -> here ----------------------------------------- Harbinger Hitlist Famine (Downpour/Dross) ✓ War (Mines/Ashpit) ✓ Death (Mausoleum/G...39.7k downloadsupdated 4 mo ago
- Heaven's Call [Solar Update](RGON)by UltrinikDO NOT HAVE INSTALLED OLD HEAVEN'S CALL VERSION!!! THIS MOD REQUIRES TO FUNCTION Check Isaac Guru's page for more detailed information Follow Heaven's Call on Twitter Mirror download for manual installation Play Heaven's Call Suika 13 new boss battles await your challenge! 1 FINAL BOSS! 10 Challe...37.8k downloadsupdated 14 mo ago
- Unique Sins (rep)by jeckjedUnique sprites for sins, based on current background • Original (with some touches here and there) for Basement, Mega Satan, and any Unfinished places • Infested - Cellar • Burnt - Burning Basement • Fungal - Caves • Stone - Catacombs • Drowned - Flooded Caves • Pale - Depths • Ghost - Necropolis...37.3k downloadsupdated 19 mo ago
- Lost and Forgottenby ENFOR!!! Lost and Forgotten requires Stage API to work properly !!! !!! Repentogon is NOT required but it's highly recomended !!! This mod is a Repentance port of the original Lost and Forgotten for Afterbirth+ with double the amount of features, improved art and performance. o Features o 100+ items 2...36.8k downloadsupdated 16 mo ago
- Better Wizoobs!by JackWizoobs no longer vanish for ages! Bored of waiting those 2 or 3 seconds for that last pesky ghost to show up? If there are only Wizoobs (or Red Ghosts) in a room and they have all vanished, one will now be forced to re-appear. :)36.0k downloadsupdated 4 y ago
- Boss Butch! (13 new bosses)by PixelPlzBoss Butch adds 13 brand new bosses to kick your ass in unique and surprising ways! If that's not enough for you, then you can also test your might in the Boss Butch challenge, featuring all of the new bosses! Also included is a special Boss Butch Bestiary™, where you can learn more about your fa...35.6k downloadsupdated 4 mo ago
- [SHAW! Update] Hollow Knight Spidersby 76561199652670853Replaces Level 2 Spider and Spider with Hornet and The Knight respectively. The mod is inspired by Hornet's spider moves with the Scuttlebrace Tool, which apparently became a meme. Idea: Hushик Sprites: CoolSkeket34.8k downloadsupdated 12 mo ago
- [RGON] Arknights : Terra, a Journeyby 76561198976289600Arknights : Terra, a Journey A crossover content mod inspired by Arknights, bringing new mechanics, encounters, and Terra-flavored content into The Binding of Isaac. Requires Repentogon to play! Arknights : Terra, a Journey is a content-rich mod that introduces original items, trinkets, enemies,...34.5k downloadsupdated 12 d ago
- The Gardenby Doug Bowen== Features == For answers to common questions, please see the FAQs and Known Issues under the Discussions Tab * New room: The Garden * 13 new passive items! * New challenge: Genesis * New curse: Curse of Mortality * New bosses: The Serpents * New transformation: Deceiver! * New music * New sound...34.0k downloadsupdated 10 y ago
- Zombie Modeby SoonsOutWelcome to Isaac Zombie, a whole new game mode ANYONE EXPERIENCING IMMORTAL ZOMBIES TRY DISABLING ALL OTHER MODS. SHOULD FIX xoxo <3 IT IS RECOMMENDED TO DISABLE ALL MODS WHEN PLAYING!!! Some bugs like infinity zombies may occur when other mods are enabled. And infinity zombies are always bad HOW...32.9k downloadsupdated 10 y ago
- Quarryby MaddogsDuring one of your escapes from your mother, you accidentally stumbled into an area left abandoned years ago, a part of the caves long forgotten and left to fester... but you're not the only one. Enter The Quarry, an expansion onto the Caves/Catacombs floors! Living gemstones, rocks rich with gol...32.1k downloadsupdated 8 y ago
- Gurgle Respriteby 76561199017419812Resprites Gurgle, Splasher's blood color updated some sprites and animations you can get old version of this mod from Change log32.1k downloadsupdated 5 y ago
- Repentance Eternal Editionby GuilhermeEternal champions, now for Repentance! New champion variant for all bosses and monsters, reworked final bosses, new ambush room variant, all inspired by the classic game What's new: • Click here to view the full documentation of this mod • Rebalances are disabled by default, enable it for a harde...31.4k downloadsupdated 4 mo ago
- King Baby to Little Sirenby 76561198324517311Just a little mod that reskins King Baby into Little Siren! She charms your familiars just like the real one and makes them attack the nearest enemy. It's so obvious, I wonder why nobody did this earlier? Unfortunately, i couldn't add any sound effects or even change the item name (the new transl...31.3k downloadsupdated 5 y ago
- Hush respriteby 76561199149887702Revisit the blue womb and face off against hush and his armada in a fresh coat of paint, soldifying him in isaac's rogue's gallery even more. Hushy is there too special thanks to Randomroyal and Mrfirework for helping me get this mod out (and fixed) (reuploaded due to a misclick and the entire mo...31.1k downloadsupdated 5 y ago
- StarFall | 35+ Unlocks & More!by 76561198447262219Shooting stars can make a wish, right? Just imagine how a Starfall can make us all happy... 2 new characters 46 new collectible items 20 new trinkets 4 new consumables 2 new hearts 1 new chest type 2 new challenges (With unlockables!) 1 new monster 40 new rooms Tons of synergies! Stay tuned to se...31.0k downloadsupdated 3 y ago
- SO_MANY_CATSby 76561199091925974VERSION THAT ONLY CHANGES SHOPKEEPERS: All shopkeepers turn into cat gifs All special shopkeepers get a golden tint and effect Angel and devil statue changed (and the satan fight) Mega Satan is that weird lookin cat30.6k downloadsupdated 2 y ago
- Visual Tellsby KhryptosWhen entering a room it adds a text saying "MUAHAHAHAHA" to the screen, in case the "Mom's Hand" enemy is encountered. When holding "Dog Tooth" it adds a text saying "You hear a dog howl" in case there is a undiscovered (super) secret room. When entering a room with a undiscovered crawlspace it a...30.1k downloadsupdated 3 y ago
- Godmode Achieved [[[BETA]]] [REP] [RGON optional] devby MINDS3TJoin the official community/development discord! Check out the official wiki! So far: A new final boss and stage!! Test your luck against this beast of a battle.. (also, unlock Godmode items!) 500+ brand new, unique treasure room layouts. This is clustered into types of treasure rooms, each havin...29.7k downloadsupdated 14 d ago
- The Ritualby SinstharThe Ritual is a random event that can appear (or not) during your journey downstairs. This mod is the new version of the Invocation Circle, which are now unavailable (to prevent some bugs with the new version). The mecanics have changed, so I decided to release a new mod. How does it work ? - Fir...29.4k downloadsupdated 5 y ago
- Sheriff: Most Wantedby catinsuranceThe Sheriff is a gunslinger character with a revolver and no time for tears... and now they're back, with new unlocks, challenges, reworks, and more, all taking advantage of REPENTOGON! The mod features 30 unlocks! 8 of those unlocks are brand new from the original. 2 characters 18 items (4 are n...28.9k downloadsupdated 1 mo ago
- Community Remix [BETA]by 76561198443814292An Old Friendship, Rekindled A labor of love and a tribute to the first ever Binding of Isaac mod is here for Repentance, with a wide variety of content that's new, familiar, and completely forgotten. Features include: 3+ new characters! Over 100 new items to find! 20+ trinkets! 60+ achievements...28.9k downloadsupdated 1 mo ago
- The Binding of Brasil - Localizado PT-BR [Desatualizado ⚠️]by TCDubsㅤㅤLocalização completa para Português Brasileiro de "The Binding Of Isaac: Repentence" ㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤO que o MOD traduz? ✮ Cartas: As Cartas foram tanto traduzidas com seu significado em nosso idioma, quanto no significado do jogo ou de Outras mídias ✮ Itens: Praticamente todos os Itens e suas descri...28.6k downloadsupdated 5 y ago
- TBOI GUNGEON EDITIONby John BalatroTBOI GUNGEON EDITION. A lot of content from Enter the Gungeon now in Isaac's workshop. Features: - 117 items from ETG (some new and others replaced, see full list below) - Gungeon OST - ETG interface and pickups - 8 new characters: the Marine, the Convict, the Hunter, the Pilot, the Robot, the Bu...28.5k downloadsupdated 6 y ago
- Isaac Soulsby Cochon VikingIsaac Souls is an obvious tribute to Dark Souls. This mod is mainly a reskin of the game, adding Dark Souls' elements to Isaac. At the moment, it replaces Monstro by the Fat Demon, which is inspired by the Asylum Demon and Ragman by the Capra Demon and the Haunt by the Moon Moth. It also adds a n...27.8k downloadsupdated 5 y ago
- Resprited Championsby 76561199275605497Resprited Champions grants the champion enemies a unique appearance to make them more interesting, inspired by how the champions in Mewgenics have a distinctive look. Currently most of the rebirth enemies have been resprited, along with various enemies from later DLCs, I'll keep updating the mod...26.5k downloadsupdated 2 mo ago
- The Binding of Bocchi the Rock!by BenShyMaruWhen Kita starts hearing the voice of God demanding to sacrifice... Nah, this is a mini mod, no story needed A while ago a friend said "Why don't you make a bocchi the rock mod?" A few days ago it was his birthday so... Why not? What does the mod bring? - The 4 Kessoku band members (untainted) -...26.3k downloadsupdated 3 y ago
- Better Enemy Varient Spritesby Jesse4060Have you ever thought that some enemy varients, like the Gurgle and Drowned Hive, looked a little boring with them just being a re-color of an exsisting enemy? Well, have I got the fix for you! This mod aims to change the enemy varient's sprites to give them their own, unique look! DaminOver and...26.3k downloadsupdated 10 y ago
- The Binding of Steve : Minecraft Crossover (AB+ version)by Ly FechaIf you like my work, please consider clicking on the like, favorite or even reward button. THIS IS THE AFTERBIRTH+ VERSION. Repentance version : MINECRAFT HAS APPEARED IN THE BASEMENT ! Play Isaac Afterbirth + with items directly coming from Minecraft ! Features : 64 Items. 10 Trinkets. 26 Enemie...26.3k downloadsupdated 8 y ago
- Muscle Man over Bloatyby 76561199569790089Sup everyone! I'm back at it again with a brand new mod, this time i changed the popular and iconic enemy "bloaty" so that it now looks like Muscle Man from Regular Show Why? the sole reason behind this mod was simply because these guys kinda sound like Muscle Man, so i thought it would be funny...26.0k downloadsupdated 19 mo ago
- [AB+] Lost And Forgottenby ENFOR== Mod Comatibility Hack is required for this mod to work properly == Repentance Version The Binding Of Isaac | Lost And Forgotten ! NOW COMPATIBLE WITH SEWING MACHINE MOD ! ----------(o)---------- This mod combines my previous mods Lost Items Pack and Lost Items Pack Expansion alongside with a l...26.0k downloadsupdated 6 y ago
- Skill Issuesby TidloasYou've been spamming me for three years—I've heard you <3 Skill Issues bundles three accessibility / visibility mods into one: high-contrast telegraphs for stomp/jump attacks, explosion blast-zones, and laser trajectory indicators. It replaces: - Coming Down! - Watch out, Explosion! - Watch out,...25.1k downloadsupdated 6 mo ago
- Whore Of Babylon: Isaac's Secret Stash 18+by 76561199663887439WoB: Isaac's Secret Stash +18 Is a Huge Mod for +18 for The Binding of Isaac! NOTE: THIS MOD DEPICTS THE CHARACTERS AS +18 Year Olds, PLEASE DO NOT HATE ON THE CREATOR OF ANY OF THESE SPRITES Official Discord Server: Credit || The Team: MinyGold FilteredTea M4RS-4600 Barley Aioros jinman ThabithT...24.7k downloadsupdated 2 y ago
- Rooms Galore!by 76561198325454024Tired of seeing the same-old rooms every run? Bored of the same weak-sauce enemies in the vanilla paths? Wished that void was actually interesting? Well this is the mod for you! Rooms Galore adds over 3000+ rooms to the game, including boss rooms, secret rooms, rooms from both the main and alt pa...24.6k downloadsupdated 2 y ago
- lego skeletonsby 000 Glue GunnerSkeletal enemies will make lego character death sounds when defeated.24.0k downloadsupdated 6 y ago
- Mom Barefootby 76561198341223348Barefoot: Mom's Legs Replaces: Mom's Legs - Barefoot Red variant - Black stockings Blue variant - White stockings Changelog V1.1: Epic update! Replaced Mom's voice lines. V1.2: Replaced Delirium form variants and replaced BGM. V1.3: Replaced Mom's Hand and its variants. V1.4: Modified some of Mom...23.9k downloadsupdated 2 mo ago
- Arcade Cabinetsby 76561198876704734CERTAIN SECTIONS OF THIS MOD MAY BE DANGEROUS TO PEOPLE WITH PHOTOSENSITIVE EPILEPSY AS OF AUGUST 11TH 2022 THIS MOD IS NO LONGER SUPPORTED. THANKS FOR UDNERSTANDING. also its highly experimental and it may shit the bed every once in a while. use responsibly We at Funnyman Modding Enterprises are...23.5k downloadsupdated 4 y ago
- Smart Cullingby DevTHIS MOD WILL BE DEPRECATED IN THE NEAR FUTURE IN FAVOR OF A BETTER REPENTOGON VERSION! The vanilla version will only receive critical bug fixes from this point onward What does this mod do? It culls redundant entities, transfers their damage, and stops the game from stealing your DPS Repentogon...23.3k downloadsupdated 2 mo ago
- Bruh Damage Soundby NoFiltersthis mod will increase your iq.23.0k downloadsupdated 6 y ago
- Neko Polty [Repentance]by 76561198981646768*throws a bucket at you cutely*22.2k downloadsupdated 5 y ago
- Limbo Deals 2by The_Evil_PickleThis mod adds a third kind of deal room that can appear after boss fights: a Deal with the Old Gods (or Limbo deal for short). It won’t replace devil or angel deals - it appears when no other deal opens, or in rare cases alongside one of the other deals. Items in these rooms are free, and you can...22.2k downloadsupdated 4 y ago
- POTATO PACK 2: Game Tweakersby ☢ Nato Potato ☢A collection of the mods I've made that modify the game mechanics, most of which are totally customizable using the Mod Config Menu. The pack includes: No Health Cap, No Pickup Cap, No Pocket Cap, No Curses, No Costumes, No Empty Pedestals, Custom Starting Items, Custom Base Stats, Custom Stat Ca...21.9k downloadsupdated 12 d ago
- Rebalanced Greedier Mode Waves!by TheTurtleMelon1500+ Greedier Mode waves rebalanced to be much less BS, overwhelming and unfair! Many Annoying enemies types such as Death's Heads and grey Hosts removed entirely! We all know what an unbalanced mess Greedier Mode is, especially on the first few floors and everyone was hoping we would get some b...21.9k downloadsupdated 5 y ago
- Fuck Lumps [AB+/Rep]by BennySomeone told me they didn't like lumps so now they've been deleted from the earth. More specifically, they've been replaced with Para-Bites. Enjoy not encountering these guys.21.3k downloadsupdated 6 y ago
- Sucker Respriteby 76561199017419812resprites suckers, spits, and inks20.7k downloadsupdated 5 y ago
359 enemies mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

