The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth pickups mods
Everything filed under pickups by its own author, ordered by how much it is used.
405 pickups mods, most downloaded first · newest update 29 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
405 pickups mods
- Crash Bandicoot - Aku Aku Holy Mantleby CrashpunkOOGBAGAH! It is I, Aku Aku! My duty is to protect you! Replacement for the Holy Mantle and Holy Card. Mod Config Menu support. Choose between Aku Aku, Uka Uka and Lights Out/Jaws of Darkness Aku Aku!8.8k downloadsupdated 9 mo ago
- More Treasure - Better Co-op!by BigrojobearPlay co-op with your friends and don't get item starved. Extra items have been added to treasure rooms, planetariums, boss rush, angel rooms, devil rooms with some other bonuses along the way.8.7k downloadsupdated 5 y ago
- Crow Headby ☢ Nato Potato ☢Crow Head is a passive item that has a chance of spawning a half soul heart when you kill an enemy. At 0 luck, there is a 3% chance of spawning a half soul heart and it increases by 1% for each 3 luck you have, capping at 15%. (e.g. 9 luck = 6%, 18 luck = 9%, 27 luck = 12%, 36 luck = 15%) You can...8.7k downloadsupdated 8 y ago
- Repentance Negative-by 76561199094088506We present to you a mod that is not of the best quality, but with interesting jokes! Also, dig through the mod files, you never know what might be hiding there... Repentogon required! Adds 2 new character! Adds 30+ new items! Adds 5+ new trinkets Adds 1 new card, pill and new pickups and machine...8.7k downloadsupdated 8 mo ago
- Auto-Pickup Coins in Greed Modeby kittenchillyAutomatically picks up any coins that would spawn at the end of a Greed Mode wave! Also automatically heals the Keeper.8.7k downloadsupdated 5 y ago
- Rib Cageby ☢ Nato Potato ☢The Rib Cage is a passive item that gives you 1 bone heart and makes you take red heart and soul heart damage before bone heart damage, allowing you to keep the extra red heart space from bone hearts until you get some more red hearts. Works well with the forgotten. (does nothing on sacrifice spi...8.6k downloadsupdated 5 y ago
- Balanced Starter Choicesby 76561199114159195Tired of walking into your very first Treasure Room and getting stuck with a single random item? Balanced Starter Choices replaces the lone starting pedestal with a configurable set of item choices, just like the "There's Options" pickups — pick one, and the rest vanish. WHAT IT DOES - On your fi...8.6k downloadsupdated 3 mo ago
- The Cursed and Brokenhearted - "I Never Forgot You"by 76561198813288416Notice I will not update this any further, I just readded it so people can play it Prerequisites for the best experience StageAPI - For the new bosses and such MMC - For the new music in the game! MinimapAPI Immortal Hearts from Team Compliance - For easier new personality unlock! EID - descripti...8.6k downloadsupdated 3 y ago
- Unique chest poolsby zzzzzzzzUnique Chest Pools This mod changes the item pools of the stone and eternal chests to make them feel more unique and interesting. The stone chest pool contains all sorts of stone and rock related items. The eternal chest pool contains items that are related to/give you eternal hearts and revival...8.6k downloadsupdated 4 y ago
- [REP+] LittleBigPlanet Bubbles Coinsby 76561198830744178Changes all coins and HUD elements with LittleBigPlanet score bubbles! All coins have special sounds :) Penny : Pink bubble Nickel : Blue bubble Dime : Red bubble Lucky penny : Green bubble Golden penny : Yellow bubble The mod should work on all versions.8.6k downloadsupdated 20 mo ago
- BeckyMod [Tainted Update]by 76561198992641386Play as Becky and Her Ghost Friend, Characters originally made after an Art Challenge Becky: You cannot shoot tears, your only attack method is a really bouncy ghost friend Devil and Angel Deals are swapped too Tainted Becky: Use Many different Spells, randomized each Run Acquire more through Dev...8.4k downloadsupdated 2 mo ago
- Faith's Rewardby DaGammlaDo you have a bad Computer? Do the fireworks produce lag? Just press "F1" and you're save! CAUTION ! This mod is possibly not compatible with others but Works perfectly with True Co-op Content : --Dynamic Boss drops-- Bosses have a chance to spawn Boss specific items like Mask of Infamy -> Isaac'...8.3k downloadsupdated 8 y ago
- No Useless Heartsby Iris HeartThis mod makes every base game character able to pick up and utilize any base game heart! Details below. This mod is a mainly a compilation mod of my other smaller mods that are aimed at individual characters, except for Blue Baby who doesn't have his own separate mod by me, because such mod exis...8.1k downloadsupdated 4 y ago
- The Binding of Brazil (AB+)by TCDubs✎ 𝗥𝗲𝗽𝗲𝗻𝘁𝗮𝗻𝗰𝗲: --------------- A Tradução Brasileira de "The Binding of Isaac: Afterbirth +" ~Todos os Itens e Suas Próprias Descrições ~Pílulas, Cartas, Runas e Suas Descrições ~Alguns Nomes de Bosses ~Os Desafios ~O Bestiário ~Interface ~Todas as Conquistas ~Booster Pack 1,2,3,4 e 5 ~Andares ~ S...8.0k downloadsupdated 8 y ago
- Patched heartsby PreynA new cute and cuddly heart has appeared in the basement! What does it do? The new "Patched heart" works just like a regular red heart. Pick it up and it will fill your heart containers (or bone hearts) with some red health! However, the hearts also have another hidden effect. If isaac had his he...8.0k downloadsupdated 4 y ago
- Fast Buyby ☢ Nato Potato ☢Very simple. Buying bombs/keys/hearts from shops when you have restock speeds up like donation machines. Makes buying from shops faster which saves time if you have a lot of money and want to buy a lot of stuff. This is included in POTATO PACK 2.8.0k downloadsupdated 8 y ago
- Health Insuranceby ☢ Nato Potato ☢Health Insurance is a custom active item which allows you to buy heals before you need them. Using Health Insurance takes 3 coins from you (not working if you have less) and turns heart pickups in the room into coins, when you have empty heart containers it will heal you half a red heart for each...7.9k downloadsupdated 5 y ago
- Angel Beggarby DrarkyelRequires Repentogon! Angel beggar appears in the basement! Adds a friendly counterpart to demon beggars, which asks for soul hearts instead of red hearts. Angel Beggar: Angel Beggar asks for half soul/black hearts, having a chance to drop sacks, eternal hearts, eternal chests or an item from ange...7.9k downloadsupdated 8 mo ago
- Fancier Heartsby 76561199017158324a mod that enhances the look of your heart UI, the heart pickups and the chargebar. enjoy♥7.9k downloadsupdated 2 mo ago
- buwenby 76561198347365682=BuWen Mod= 【Mod内容】 ①共计580 左右新的道具。 ②30位新角色(15表角色+15里角色) ③7种mod特有角色属性(基础攻击力、暴击率、暴击伤害、攻击力加成、最终伤害、技能加成、冷却缩减) ④34种“精英技能”;全新机制,怪物生成时有概率被赋予随机技能效果,每个“精英技能”有着各自各样的效果 ⑤12种“精英怪物”;全新怪物,不同怪物有着自己的攻击方式以及特殊机制。 ⑥添加伤害飘字显示,反馈拉满。 ⑦35 种以上新的卡牌、32 种以上新的药水效果、新的8种套装效果。 ⑧空想神话装备体系(完美还原崩崩,膨胀的开始) ⑨难度选择机制,可更具游戏进程和发育情况修改难度。以及...7.9k downloadsupdated 7 d ago
- PLUSH REI COINby 76561199025488140This is my first work with animation, if you find a bug or something else, then write in the comments7.9k downloadsupdated 4 y ago
- Infinite coins [REP(+) AND AB(+)]by 76561199124047182Infinite Coins! 💰 Never run out of coins! Auto-refills to 99 everytime. Works on AB+, Repentance & Repentance+! Shops, machines, donations: Spend freely. No achievements broken. More from me: 🔑 Infinite Keys 💣 Infinite Bombs7.8k downloadsupdated 10 mo ago
- Persona Tarot Cardsby 76561198871986199Reskins all tarots + tarot card adjacent items into the persona tarots, along with some other persona themed card reskins! ====================================== This mod retextures: - All upright tarots into the persona 3/4 arcanas (Including The Sun Pop-up!) - All reverse tarots into the person...7.7k downloadsupdated 22 mo ago
- Cobson (Beast resprite)by 76561198338773226HWABAG Bone chilling, spine tingling, genre redefining, slow-burn resprite mod that will change The Beast with Cobson. no 'p embedded.7.7k downloadsupdated 3 y ago
- Neco Arc voiceoverby 76561198338773226Changes the narrator voice to Neco-Arc voice. All voiceovers have been changed by using AI.7.6k downloadsupdated 3 y ago
- ULTRAKILL CARDS ULTIMATEby 76561199495557184Hey! There's also an alternate version of this mod now, which also includes full resprites of the cards by KironDash (and me, I guess), so be sure to check it out! Behold! Your biggest dream of characters for mid ass game yelling at you when using consumables finally came true! Inspired by this j...7.6k downloadsupdated 17 mo ago
- McDonalds Respritesby 76561199102200098Resprites some HP Ups into McDonald's Foods! It also renames them accordingly. Currently resprites Raw Liver, Lunch, Dinner, Dessert, Breakfast, Rotten Meat, A Snack, Midnight Snack, and Supper. I'll add more if I'm not lazy7.5k downloadsupdated 17 mo ago
- Welkin Moon's Homecoming - Columbina Character MODby 76561199294068588This MOD supports Repentance and Repentance+. REPENTOGON is not required! This MOD adds a new playable character from Genshin Impact. Columbina Hyposelenia "The Damselette" The Fatui Harbinger codename "Columbina" is inspired by the stock character of the same name from Commedia dell'arte. In Ita...7.5k downloadsupdated 1 mo ago
- [Rep+/Rep] Kicks and Giggles (3 characters, 40+ unlocks, and more!)by 76561198917870427A tiny mod with three characters (tainted characters included), two interesting challenges and a bunch of unlocks! This mod is fully backward compatible with Repentance/Repentogon! This mod adds… • 3 Characters? • 3 Tainted Characters • 28 collectibles? • 29 trinkets • A new NPC • 2 custom challe...7.5k downloadsupdated 10 mo ago
- Fix Multiplayer Item Spawnsby BlueRajaFix a few issues related to items spawning in Repentance multiplayer: Prevent active items from spawning in boss rooms. If an active item is spawned in a boss room and every player has an active, no one can pick up any of the other items. Spawn extra items in Greed Mode. Greed Mode is nearly impo...7.5k downloadsupdated 6 y ago
- WhiteNight Dogmaby 76561198365949909Changes Dogma to WhiteNight Aleph Abnormality from games Lobotomy Corporation and Library of Ruina Features: - WhiteNight as Dogma - New music - New sound effects - Styled visual effects of second phase 🔑🌙 Project Moon7.4k downloadsupdated 7 mo ago
- Cha-Ching Coinsby VilePowderChanges the coin pickup sounds to be more $$$. mm delicious dopamine. i love capitalism7.3k downloadsupdated 4 mo ago
- No duplicate golden pickupsby 76561198381860001如果在有金钥匙的情况下掉落了金钥匙则转换为金炸弹,金炸弹同理 如果两个都有则转换为金金币(如果你玩的是里该隐那么就不会转换) If a golden key is spawned when you already have a golden key, it will be converted into a golden bomb. The same goes for golden bombs. If you have both of them at the same time, they will be converted into golden coins (Excluding Tai...7.3k downloadsupdated 4 y ago
- Deep laboratories (AFTERBIRTH PLUS VERSION)by Mogumi-------------------------------------------------------------------------- DEEP LABORATORIES FOR REPENTANCE IS OUT! -------------------------------------------------------------------------- IMPORTANT! Don't force this mod in Repentace! the new DLC changed a lot of sprites and how things work in...7.2k downloadsupdated 6 y ago
- It's The Key Trackerby fartsox64Displays an icon when you've invalidated the "It's the Key" achievement during your run.7.1k downloadsupdated 5 y ago
- !Astro-rulesby 허농이한국어 설명은 하단에 있습니다! Please Note This. This mod was implemented for the personal streaming. Therefore, It may be inappropriate for general runs. Also, we cannot guarantee the compatibility with other mods. Introduction Redrawn Mod was developed for TBoI: Time Attack Race, which is one of the content...7.1k downloadsupdated 7 d ago
- Moon heartsby 76561199090151127Introducing Moon Hearts Moon hearts are a new heart variant. - They have a 30% chance to replace an Black heart and only appear once per floor. - When you move to the next floor, you will receive various stats depending on the damage you have done on the previous floor + a black heart. - But be c...7.1k downloadsupdated 3 y ago
- Blue Hearts for Blue Babyby O_oWhile playing as ??? (a.k.a. Blue Baby), all red hearts - full red hearts, half red hearts, 1+1 free hearts, and scared hearts - are immediately converted to half soul hearts. Code to replace pickups with other pickups was adapted from Strawrat's Penny Pincher challenge. So credit goes to him for...7.1k downloadsupdated 9 y ago
- Gold Cardby ☢ Nato Potato ☢Using the Gold Card turns your keys and bombs golden (for the rest of the current floor), turns 1 of your hearts golden and if you're running Repentance it turns your held trinkets golden (smelted/gulped trinkets are unaffected). Powerful, but has a low drop rate. This card affects the players in...7.0k downloadsupdated 22 mo ago
- Greed's Blessingby KerkelGREED IS GOOD!!! The Greed Donation Machine has no use after unlocking the Keeper, but keeps stubbornly showing up anyway. Time to give it the spotlight again! Donating 33 coins to the Greed Machine after the Keeper is unlocked will now make your next normal run start with an additional random it...7.0k downloadsupdated 17 mo ago
- Isaac Reforged [Afterbirth+]by KaliThis mod aims to add and rebalance characters, synergies, and transformations, while remaining faithful to the vanilla experience. Supports External Item Descriptions! Supports Mod Config Menu! Supports Revelations! Supports Fiend Folio! & More! All changes are configurable with the Mod Config Me...7.0k downloadsupdated 6 y ago
- Miku Anouncer Modby 76561199376393245Changes all announcer dialogue into Hatsune Miku V4! Horse piills are reverbed, both because I'm lazy, and because i think it sounds nice. reverse cards are... well yeah that one was easy enough I did *some* testing, but let me know if there are any sounds where i messed the file names up (they'l...7.0k downloadsupdated 21 mo ago
- Luigi's gold keyby 76561199102149926This Changes the Golden key sound effect with the "Get key" sound effect from Luigi's mansion 1 Enjoy!6.9k downloadsupdated 2 y ago
- Niro's Collectionby NiroA collection of items and trinkets I made! All of them are updated for Repentance and support External Item Descriptions and Encyclopedia ! This mod adds: 14 new passive items 2 new active items 6 new trinkets Passive Collectibles Addiction - I need more pills! Black Swarm - Dark friends Daemon's...6.9k downloadsupdated 2 y ago
- Health and pickups packby ☢ Nato Potato ☢This pack has several items that utilize the NoHealthCap and NoPickupCap mods, it also serves as an example for other modders. Dad's Wallet: Boosts coin cap to 250, +25 coins. Bomb Sack: Boosts bomb cap to 250, +25 bombs. Key Chain: Boosts key cap to 250, +25 keys. Cardiomegaly: Boosts heart cap...6.8k downloadsupdated 7 y ago
- Redemption Community Pack [ON HIATUS]by Magpie Smoking a CigNote: This mod is on Hiatus. For more information read it on the discussions page. THE TIME TO REDEEM YOURSELF IS NOW! Redemption adds numerous items, trinkets, monsters, and much more to spicen your runs. We strive to incorporate new and exciting features to the game with a particular focus on c...6.8k downloadsupdated 4 y ago
- More Pickup Varietyby WofsaugeThis mod adds over 100+ new and unique skins for every pickup in the game. The mod provides an easily expandable spritepool, from which the visuals of any pickup can be choosen. This includes up to 6 new vsuals and the original one, in order to make the gaming expirience less repetitive and more...6.8k downloadsupdated 9 y ago
- Metal Pipe Falling Shovelby SprSnpr_Peak falling metal pipe immersion. This mod changes the sound and sprite of the falling shovel that starts the Forgotten unlock. The shadow overlay is also changed from a shovel to a pipe. Forgive me for making this...6.7k downloadsupdated 3 y ago
405 pickups mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

