Mods / pills

• PPOTATO PACK 2: Game Tweakersby ☢ Nato Potato ☢A collection of the mods I've made that modify the game mechanics, most of which are totally customizable using the Mod Config Menu. The pack includes: No Health Cap, No Pickup Cap, No Pocket Cap, No Curses, No Costumes, No Empty Pedestals, Custom Starting Items, Custom Base Stats, Custom Stat Ca...21.9k downloadsupdated 11 d ago
• AAstro-pocketsby 허농이✅ 인터넷 방송인 아이작 오헌영이 제작한 모드입니다. ✅ 제작 목적: 내수용 콘텐츠 확장을 위한 신규 소모 아이템 추가 ✅ 사용 방법: 모드를 설치하면 자동으로 적용됩니다. ✅ 기타 안내: 없음 ✅ MCM 지원 여부: X (미지원) 버그, 오류, 건의 제보 디스코드 : hunyeong3563 깃허브 : 유튜브 : youtube.com/channel/UCWXBhD5SfoyJ3SUShTLz3WA/ ✅ This mod was created by the livestreamer Isaac Oh Heon-Young. ✅ Purpose:...21.9k downloadsupdated 2 mo ago
• EEnergy Drinks instead of Pillsby FischfreakadelleDrinking too many energy drinks might be bad. But do you know what's worse? Taking random pills without knowing their effects. Replaces pills with your favorite energy drinks. Now also replaces horse pills and golden pills, so you'll have a heart attack even faster.⚡️❤️ Enjoy! Check out my other...21.7k downloadsupdated 3 mo ago
• IIssac missing poster itemby Vyro OneHi guys,have you ever wondered "I want to get the lost,but how the hell can I get the missing poster?" With this mod you guys are starting with the missing poster (with issac character ) and u can get the lost To enable the mod u need to enable the mod and disable all the mods u have. Steps: Step...20.3k downloadsupdated 9 y ago
• LLet's go Gambling! [RGON]by possombullAdds awesome sound effects to the game the likes of which the world wouldnt have been ready for 10 years ago. Sounds play in some capacity for: -slot machines -fortune teller machines (technically, only when they self destruct) -all the beggars -shell game & its evil twin brother -crane games -co...19.9k downloadsupdated 2 y ago
• [[REP] The Binding Of Pokemon + Legends Expansionby 76561198429240276A MOD MADE WITH A LOT OF LOVE AND AFFECTION BY FANS, AND FOR FANS. This mod is the official sequel to "The Binding of Pokemon" from Afterbirth+ now available for Repentance. Contains characters and items from "The Binding of Legends" (Rebirth) and lots of community-contributed Pokémon content. If...18.8k downloadsupdated 3 y ago
• EEven Playfield (items for monsters)by PixelPlzThe monsters learned to use items against you! Inspired by Risk of Rain 2, Even Playfield adds a unique way to spice up your runs. Each room gives your enemies a new set of items that affects them, including stat increases, new attacks, familiars and much more. Fight against wacky combos, take on...18.5k downloadsupdated 12 mo ago
• AAlt. Daily/Online Unlock Methodsby PixelPlzThis mod uses the power of REPENTOGON to provide alternate unlock methods for the mod-exclusionary daily and online achievements. Cracked Crown is now also unlockable via achieving a streak of 7 consecutive wins. This works retroactively for save files that have already achieved this streak, simp...18.1k downloadsupdated 11 mo ago
• Tthe binning of isek: aferberts plussby Ao JonesiREPPENISS VERSION SOON MAYBE The Full Graphical Overhaul is officially back, and better than ever! One day, as Isaac descends to the basement once again, he notices that things are... off. Everything looks like his drawings or something far worse... This mod gives the entire game a new, interesti...17.6k downloadsupdated 8 y ago
• CCat for Good/Bad Pillby 76561199122359894You will see a holy cat whenever you eat a good or bad pill not compatible with mods that change player animations. Curse version:16.9k downloadsupdated 4 y ago
• AAbortionbirth Pack 2: THE HECKONINGby NarilliaWelcome friends to The Binding of Isaac: Abortionbirth Pack 2: The Heckoning, sequel to a total expansion MOD to defeat all other mods! Each item has been designed from scratch with all the care in the world to offer the ideal experience. This mod tops all other mods, EVEN the original Abortionbi...16.6k downloadsupdated 9 y ago
• NNo More Useless Items: Repentanceby Flap_JackSometimes you'll get good items, sometimes you get not-so-good items. This random chance is all part of the thrill of The Binding of Isaac. Getting items in a run that are weak or overly situational or just not good for your current synergy can be disappointing, but it becomes a whole new level o...16.2k downloadsupdated 3 y ago
• AAbortionbirth (OUTDATED, GET PACK 2)by NarilliaWelcome friends to The Binding of Isaac: Abortionbirth, a total expansion MOD to defeat all other mods! Each item has been designed from scratch with all the care in the world to offer the ideal experience. No refunds. So far, we've done 103 items, but soon enough I guarantee you our following li...15.9k downloadsupdated 9 y ago
• FFurtheranceby anchikaiSUBSCRIBE TO THE NEW MOD! The Binding of Isaac: Furtherance is a modded expansion that adds a flavorful amount of new content! Features - 42 Passive Items - 26 Active Items - 20 Trinkets - 3 Characters w/ Tainted Counterparts: Leah, Peter, & Miriam - Unlocks for all Characters - Mod Config Menu S...15.4k downloadsupdated 4 y ago
• [[REP] Unnerf Packby MiyukkiThe biggest pack of unnerfs for Repentance! Make your game as fun as it was before Repentance With this mod you can still unlock achievements! Mod has support for Mod Config Menu - you can enable or disable every unnerf separately! Mod contains updated descriptions of unnerfed items for External...15.1k downloadsupdated 4 y ago
• NNo Confusing Pillsby ViscerAVery simple mod Now you'll never confuse the golden pill for the orange pill ever again! Also, the purple pill from Four Souls is just really pretty <314.9k downloadsupdated 5 y ago
• EEIDMoreby Erndog~~~~ I doubt I will be updating the mod anytime soon, I would check out/keep an eye out for ☢ Nato Potato ☢ community eid collab mod. As with more people using it and contributing there will be more options there with the ability to customize it to your liking. The description on the mod page exp...14.7k downloadsupdated 9 y ago
• BBest Startby alberto64674ytBest Way To Start you can start with some hearts in spawn a few chests money golden key golden bombs.... Warning: y spawn random bombs stay alert cause a few times when start can spawn troll or megatroll bombs if your run is ruined cause bombs just press "Ñ" or console table and just type "restar...14.3k downloadsupdated 4 y ago
• CCurse of The Middle Finger Cat [MiniMAPI]by 76561199122359894MiniMAPI Required!! this mod changes curse of the lost question mark with the middle finger cat.14.2k downloadsupdated 4 mo ago
• VVitamin V Item Packby KingBobsonThis mod adds 12 new items and 4 new trinkets to the game, across a variety of pools. Be dazzled! Be amazed! All the ideas in this mod are from various anons. Most of the sprites are from stewartisme, with some anonymous contribution. Includes support for EID and Encylopedia! WARNING: The Univers...14.0k downloadsupdated 4 y ago
• DDaydream all Dayby 76561198402142170Let's step into this wonderful DAYDREAM, and experience items and characters that can only be imagined in your dreams! Features "Daydream All Day" is a mod with 100+ dreamlike new items, trinkets, and characters. All items are filled with unique effects, allowing you to experience infinite pleasu...13.6k downloadsupdated 15 d ago
• PPudding And Wakaba [REP/RGON/WIP]by 리셰The various uncommon girls arrived to basement! REPENTOGON/REPENTANCE ONLY! Does not work with Afterbirth+! Requires External Item Descriptions(English/Korean/Chinese(wip)) Mod Includes : 11 Characters 80+ Items 15+ Trinkets 15+ Card/Runes 10+ Pills 20 Challenges Items Under construction, Using E...13.1k downloadsupdated 11 mo ago
• RRainbow Poop Gives a Soul Heartby Iris HeartDestroying a rainbow poop now grants 1 soul heart to characters with no red heart containers. Also, Full Health pill, The Sun and 2 of Hearts cards now also grant 1 soul heart to characters with no red heart containers.13.0k downloadsupdated 5 y ago
• FFurtheranceby BennyA complete overhaul of the The old Furtherance MOD originally released in 2022. Coded from the ground up under the experienced eye of a single coder with the power of REPENTOGON, this new release breathes new life into every corner of the original MOD to create a sizeable quality package of conte...12.7k downloadsupdated 15 mo ago
• NNo Pocket Capby ☢ Nato Potato ☢This mod allows you to hold as many trinkets, cards and pills as you want. You can edit the limits by using the Mod Config Menu or by using console commands, you can set the limits to -1 for infinite or to 0 to prevent the player from being able to carry any trinkets or pills/cards at all. While...12.6k downloadsupdated 23 mo ago
• IIM FUCKING INVICIBLEby GodWladiFeel the power of invincibility like never before with this custom mod! Sundowner from Metal Gear Rising: Revengeance will support your with his sexy voice. When you activate invincibility items like Book of Shadows, My Little Unicorn, or the Algiz Rune, you'll be immersed in intense sound effect...12.5k downloadsupdated 4 mo ago
• MMore Minisaacsby Iris HeartThis mod is inspired by Unique Minisaacs mod: I love the variety of minisaacs that mod brings, so I wanted to see results of that mod more often, and that's why I made this mod. This mods adds a new heart type: Cell Heart. Red Hearts have a 10% chance to be replaced with Cell Hearts. Cell Hearts...12.4k downloadsupdated 5 y ago
• FFlint and Steel replaces Balls of Steelby 76561198877204046Replaces the announcer voice line for "Balls of Steel" with "Flint and Steel", including the pop-up text. The horse pill announcer is now deep fried I, The REAL Edmund McMillen, says that this is quality content on the workshop. for legal purposes this is a joke, edmund dont become back my money12.0k downloadsupdated 19 mo ago
• MModJam Vol. 2 (14+ New Characters!)by 76561199208948209REPENTOGON+ IS REQUIRED! You know the drill, download Repentogon+ here! ModJam Vol. 2 focuses on CHARACTERS, rather than items! We present a whopping 14(?) characters, 7 normal characters and 7 tainted characters. Each team had to make a normal character over the span a few weeks, and then was gi...11.2k downloadsupdated 2 mo ago
• ((AB+) Genesis+ Revivedby BroskiPlays on ROG Ally1.2 BUGFIXES + 1 NEW ITEM ----- Fixed Trapdoor appearing in Catacombs / Caves Fixed Rune not able to be picked up Fixed Boss Room related Bugs Fixed all stuff related to Catacombs Disabled Stagesapi Added 1 new Item: Too Much Water! Enjoy the update and be sure to send me any bug reports :) GENES...10.8k downloadsupdated 9 y ago
• 顿顿悟中文eid图鉴/zEpiphany_EID_Chineseby YouDuckBoom本mod提供了顿悟(ephiphany)的汉化，使用前请确保订阅了eid和中文版mod配置菜单，并将语言调整为中文 感谢支持，欢迎留言10.8k downloadsupdated 3 y ago
• AApocrypha: On The Rocksby 『Sora』Apocrypha On The Rocks is the latest, Repentence update of Apocrypha, almost doubling the number of items in the mod. Apocrypha has items, trinkets, enemies, challenges, transformations, pills and cards, and even a whole new type of consumable: Floppy Disks! All the details for the full mod's con...10.7k downloadsupdated 15 mo ago
• JJerma says ALL pickupsby Apollo JusticeAbout a year and a half ago, I uploaded a mod that many say changed the face of The Binding of Isaac: Repentance as we all know it: The Jerma MONEY SFX mod Today, I am proud to stand before you to say that we have achieved something we thought was only possible in our dreams. Using the latest tec...10.7k downloadsupdated 18 mo ago
• SSweet Halloweenby 76561199121244854Trick or treat? This mod adds 6 new candy consumables to the game, each with a random set of effects! On top of that, it also adds 7 items and 5 trinkets. For more information, watch the showcase video. ...or alternatively, go to IsaacGuru Requires REPENTOGON10.6k downloadsupdated 20 mo ago
• TTETO BEGGARby 76561199172310537This mod replaces the devil beggar and hellgame sprites with kasase teto!1!10.5k downloadsupdated 12 mo ago
• NNice Cockby 76561198935929219Replaces the 'I Found Pills' sfx with Nice C*ck This mod may not be compatible with other mods that change the names of cards/pills, such as "Balls With No Steel", etc. Just to be safe, Repentance only. If this mod doesn't work, check the pocketitems.xml files of other mods and ensure they're not...10.0k downloadsupdated 3 y ago
• DDOOM in Isaac!by PoondaedalinWarning: This mod may not be suitable for people who are sensitive to flashing lights or effects! If you want to play the first level with mouse look/firing, click here! (note: just the first level) "Can it run DOOM?" "Yes, yes it can." "...sort of." This mod contains a few levels of a DOOM/Wolfe...9.8k downloadsupdated 14 mo ago
• BBedroom Expandedby dpower12Do you want to find new types of bedrooms? with new trapdoors, objects and beds that give different buffs? Then this mod is for you! Welcome to Bedroom Expanded! (Repentogon only) Bedroom Expanded adds currently: 6 new bedroom types 120+ new Bedroom layouts 2 new trapdoors that lead somewhere new...9.7k downloadsupdated 12 mo ago
• BBattle Fantasyby 76561198881880834If you are on Repentance+, a more updated version of the mod can be downloaded HERE!! Battle Fantasy MOD is a medium sized content mod made with appreciation for Isaac and its Flash roots. Over 2 years in the making, the mod has grown to add the following features: Several items based on classic...9.5k downloadsupdated 7 mo ago
• GGenesis+ Septic Shock!by budjmtSomething smells funny beneath the Caves... After over 2 years, let's go to the Septic! - Septic is back and in the best shape of its life! It's been ported to the newer StageAPI for greatly enhanced stability and performance. - To access the floor, go to Ch 2 and look for a greenish rock. - The...9.4k downloadsupdated 7 y ago
• DDamage up/down pills [No longer supported/Is bad]by SageAdds a damage up and a damage down pill to the game. WARNING -----Does NOT work with Fiend Folio and Repentagon seems to mess it up---- This mod barely works and falls apart easily. Horse pills don't seem to work anymore either. Use with caution. -----Barely held together by string----- Damage up...9.1k downloadsupdated 5 y ago
• Tthe binding of maggy's toy box and WOB isaac's secret stashby 76561199032451894BUG FIX: 超级撒旦和鲍勃的烂头动画修复！ MegaSatan and Bobsrottenhead Animation fix! 炸弹乞丐被炸不出炸弹修复！ Fixed the Bomb Bum not dropping an insta-exploding bomb when blown up！ 究极傲慢宝宝瞎几把乱闪修复！ Fixed the Ultra Pride Baby incorrect flashing animation! 个人整合包，非原作者，模组来源： maggy's toy box maggy's toy box reborn WOB isaac's sec...8.9k downloadsupdated 11 d ago
• TThe Binding of Isaac: Eternal Youthby snooch"The Binding of Isaac : Eternal Youth" Is planned to be a huge content pack for the game! This is a mod made from a small bunch of people who share similar passion for the game. Current Content ============== 10 Items Abomination Baby - A familar that likes to reward you with a troll bomb at the...8.9k downloadsupdated 10 y ago
• ""Isaac we love you" replaces tears downby Hex: Consume SoyReplaces both Tears Down pills with the "Isaac we love you" voice line. He's happy!8.9k downloadsupdated 3 y ago
• RRooms and Roams (700+ rooms)by MarbleTearsHello, welcome to Rooms & Roams!! an expansive mod for more adventures This mod add Adds: 100+ rooms for every chapter (basement, caves and depths) 50 + rooms for every alts (burning basement, cellar, etc) 50 + rooms for every alt2 chapter (downpour, mines, etc) + 200 special rooms (planetariums,...8.9k downloadsupdated 14 mo ago
• TTBH LUCKYby 76561199074595760TBH now sounds in Luky pennies and bad pills effect The funny thing NOW with Creature appearing when you pick the coins or taking a bad pill8.8k downloadsupdated 4 y ago
• RRepentance Negative-by 76561199094088506We present to you a mod that is not of the best quality, but with interesting jokes! Also, dig through the mod files, you never know what might be hiding there... Repentogon required! Adds 2 new character! Adds 30+ new items! Adds 5+ new trinkets Adds 1 new card, pill and new pickups and machine...8.7k downloadsupdated 8 mo ago
• TThe Cursed and Brokenhearted - "I Never Forgot You"by 76561198813288416Notice I will not update this any further, I just readded it so people can play it Prerequisites for the best experience StageAPI - For the new bosses and such MMC - For the new music in the game! MinimapAPI Immortal Hearts from Team Compliance - For easier new personality unlock! EID - descripti...8.6k downloadsupdated 3 y ago

155 pills mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.