Mods / pills

• DDr. House Over PHDby 76561199231191134This mod changes the sprite for the items PHD - Dr. House False PHD - Evil Dr. House note: if you dont like Evil Dr. House just deleting him from the mods files via picture should remove him4.1k downloadsupdated 16 mo ago
• FFiend Folio [RUS]by Dick NukemFiend Folio Изменения внесены только в части переведенных строк для мода EID (External Item Descriptions) Как установить: 1. Скачать все другие необходимые моды, а именно: Fiend Folio: Reheated - 500 New Monsters! Custom Stage API External Item Descriptions - настроить на русский язык 2. Установи...4.0k downloadsupdated 3 y ago
• AAwfulTweaks [RGON]by Mr. HeadcrabThis mod requires Be sure to follow the full install instructions on repentogon.com Are you sick of the standard, well-thought-out challenge mods out there? Have you found yourself wanting a mod made primarily for the enjoyment of anyone watching you play? This might be the mod for you! This mod...3.9k downloadsupdated 4 mo ago
• LLSD Consumableby ArcticPlease leave a comment, I'd love to know what you think of my first mod! It's acid! Take it and freak out. Think your parents are trying to kill you! This mod adds a consumable with a 1/32 chance to replace cards and runes. Using it will make you see crazy sh*t, man. On top of that, it applies a...3.9k downloadsupdated 9 y ago
• ""Dog covering nose meme" SFXby 76561198324384778Changes the negative sound effect for consuming bad pills, losing on a slot machine or pressing buttons for the semi-popular "dog covering nose meme" audio. I hope you'll like it!3.8k downloadsupdated 4 y ago
• 110 cards packby 7656119880340664810 new cards have appeared in the basement! ·This mod adds 10 new cards with new effects to the game! Cards list: - God card *Effects: It has a 95% chance of giving you a coin and a 5% chance of giving you godhead *Spawn chance: 0.5% - Mirror card *Effects: Changes all your items (like D4) *Spawn...3.8k downloadsupdated 7 y ago
• AAntibirth for AB+ (and Repentance)by im_temDo not install this if you want to play Antibirth, go to antibirth dot com instead Antibirth was made by P.E.N.I.S team, not me or even better, get yourself Repentance instead of running this, dammit! ----- Antiborne is now real, even for Afterbirth+ (now also for Repentance!) Let's be honest, yo...3.8k downloadsupdated 4 y ago
• TThe Binding of Pokimon Mystery Dungeon [Afterbith + Edition]by NarxThe Binding Of Pokimon Mystery Dungeon is a mod that turns Isaac's basement into pokemon mystery dungeon world, includes PMD levels, bosses soundtrack sound effects and much more... DOWNLOAD FULL VERSION HERE: mega. nz/file/yhEADZpa#X9R9MN2_tNITsbixkOxlmknccSU1cBjsD5GEUmaVbwI FEATURES: -Playable...3.6k downloadsupdated 6 y ago
• UUnnerfed Item Mimicsby usernamenotavailableUnnerfs Blank Card and Placebo to back to how they used to be before Repentance, meaning all cards and pills take 4 rooms to recharge. Also changes Clear Rune to act like that as well because why not. Note that this will essentially make some of the new runes like Soul of Lilith extremely overpow...3.6k downloadsupdated 5 y ago
• [[Ab+ Only] Bugfixes and Improvementsby GuilhermeThis mod is a compilation of my bugfixes and improvements mods, it has a low priority so any mod should overwrite it, maximum compatibility! All following mods are already included in this mod, don't subscribe to them! (Bug fixes) Fixed Bandage Girl Body Fixed Peep/Bloat's eye hitbox Fixed 1 Boss...3.6k downloadsupdated 6 y ago
• CCurse of the Neco Arcby 1d4koboldsReplaces Curse of the Lost with funny cat a friend wanted this, pray for their sanity art credit @potatomochii on twitter3.6k downloadsupdated 4 y ago

155 pills mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.