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The Binding of Isaac: Rebirth

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The Binding of Isaac: Rebirth mods

The Binding of Isaac: Rebirth pills mods

Everything filed under pills by its own author, ordered by how much it is used.

158 pills mods

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Rooms and Roams (700+ rooms)by MarbleTearsHello, welcome to Rooms & Roams!! an expansive mod for more adventures This mod add Adds: 100+ rooms for every chapter (basement, caves and depths) 50 + rooms for every alts (burning basement, cellar, etc) 50 + rooms for every alt2 chapter (downpour, mines, etc) + 200 special rooms (planetariums,...8.3k downloadsupdated 12 mo ago
Faith's Rewardby DaGammlaDo you have a bad Computer? Do the fireworks produce lag? Just press "F1" and you're save! CAUTION ! This mod is possibly not compatible with others but Works perfectly with True Co-op Content : --Dynamic Boss drops-- Bosses have a chance to spawn Boss specific items like Mask of Infamy -> Isaac'...8.3k downloadsupdated 8 y ago
Repentance Negative-by 76561199094088506We present to you a mod that is not of the best quality, but with interesting jokes! Also, dig through the mod files, you never know what might be hiding there... Repentogon required! Adds 2 new character! Adds 30+ new items! Adds 5+ new trinkets Adds 1 new card, pill and new pickups and machine...8.3k downloadsupdated 6 mo ago
No Useless Heartsby Iris HeartThis mod makes every base game character able to pick up and utilize any base game heart! Details below. This mod is a mainly a compilation mod of my other smaller mods that are aimed at individual characters, except for Blue Baby who doesn't have his own separate mod by me, because such mod exis...7.8k downloadsupdated 4 y ago
The Binding of Brazil (AB+)by TCDubs✎ 𝗥𝗲𝗽𝗲𝗻𝘁𝗮𝗻𝗰𝗲: --------------- A Tradução Brasileira de "The Binding of Isaac: Afterbirth +" ~Todos os Itens e Suas Próprias Descrições ~Pílulas, Cartas, Runas e Suas Descrições ~Alguns Nomes de Bosses ~Os Desafios ~O Bestiário ~Interface ~Todas as Conquistas ~Booster Pack 1,2,3,4 e 5 ~Andares ~ S...7.8k downloadsupdated 8 y ago
buwenby 76561198347365682=不稳mod= 【Mod内容】 ①共计550 左右新的道具。 ②30位新角色（15表角色+15里角色） ③7种mod特有角色属性(基础攻击力、暴击率、暴击伤害、攻击力加成、最终伤害、技能加成、冷却缩减) ④35 种以上新的卡牌、32 种以上新的药水效果 ⑤新的8种套装效果。 ⑥空想神话装备体系（完美还原崩崩，膨胀的开始） ⑦难度选择机制，可更具游戏进程和发育情况修改难度。 ⑧该Mod最终试炼挑战！——“可疑的照片"。 ⑨大量新机制道具，都很有意思！部分道具效果太长，字有点多，斯米马赛:) ⑩该mod兼容忏悔+并且能够支持2人多人游戏【添加的属性】角色血量下方的数字，从左到右分别是：（...7.7k downloadsupdated 2 mo ago
Better Retro Visionby slapjakChanges the Retro Vision pill voice line to be bitcrushed. I always thought it should be like this. Now with horse pill support.7.6k downloadsupdated 4 y ago
! 한국어 2 (Korean 2)by 76561198448763048구독자 1,700명 감사합니다. 이 모드를 적용하고 나서, 설정에서 언어를 한국어로 바꾸셔야 아이템 이름 등이 제대로 보여요. 이 모드를 적용하고 나서, 설정에서 언어를 한국어로 바꾸셔야 아이템 이름 등이 제대로 보여요. 사진처럼 몇몇 아이템의 이름과 설명이 살짝 바뀌고 번역 오류를 수정해 주는 모드입니다. 번역 오류랑 상관없이 그냥 (아이템의 이름이나 설명이) 바뀐 것들도 있는데, 이 모드가 한국어 파일에서 번역 오류를 찾아서 수정한 게 아니라 그냥 영어 파일을 한국어로 번역한 거라서 그런 거예요. 그리고 가끔 이상한 드립...7.5k downloadsupdated 3 y ago
Syringes+by NyxreThe Syringes+ Mod adds a variety of different Syringe based items to the item pool. Future updates will add more items, pills, and a new character. Current Item List: Passives: - Used Needle (Reduces Fire Delay) - Morphine (Reduces Speed, Gives 2 Spirit Hearts) - Booster Shot (Increases Speed, In...7.5k downloadsupdated 10 y ago
Neco Arc voiceoverby 76561198338773226Changes the narrator voice to Neco-Arc voice. All voiceovers have been changed by using AI.7.4k downloadsupdated 3 y ago
Gamblecore "I Can't Stop Winning!" Over Good Pillsby LulledNullreplaces various sound effects with "I can't stop winning!" and "Let's be financially responsible!" List of the different sounds replaced: "I can't stop winning!": Good Pills Winning slots "Let's be financially responsible!": Credit Card Temperance Soul of The Keeper Ace of Diamonds 2 of Diamonds...7.2k downloadsupdated 2 y ago
Cobson (Beast resprite)by 76561198338773226HWABAG Bone chilling, spine tingling, genre redefining, slow-burn resprite mod that will change The Beast with Cobson. no 'p embedded.7.1k downloadsupdated 3 y ago
Isaac Reforged [Afterbirth+]by KaliThis mod aims to add and rebalance characters, synergies, and transformations, while remaining faithful to the vanilla experience. Supports External Item Descriptions! Supports Mod Config Menu! Supports Revelations! Supports Fiend Folio! & More! All changes are configurable with the Mod Config Me...7.0k downloadsupdated 5 y ago
!Astro-rulesby 허농이한국어 설명은 하단에 있습니다! Please Note This. This mod was implemented for the personal streaming. Therefore, It may be inappropriate for general runs. Also, we cannot guarantee the compatibility with other mods. Introduction Redrawn Mod was developed for TBoI: Time Attack Race, which is one of the content...7.0k downloadsupdated 18 d ago
the binding of maggy's toy box and WOB isaac's secret stashby 76561199032451894个人整合包，非原作者，模组来源： maggy's toy box maggy's toy box reborn WOB isaac's secret stash Rest with a pretty lady Personal modpackage, I AM NOT THE ORIGINAL AUTHOR, mod source： maggy's toy box maggy's toy box reborn WOB isaac's secret stash Rest with a pretty lady 有一个模组不兼容所以以压缩包形式保存在整合包的文件夹内 There's a mod...6.9k downloadsupdated 18 d ago
TikTok Lady Narratorby MightyKingWarioMakes The Binding of Isaac worse. Replaces all narrator lines from the base game into the terrible quirky TikTok lady. All voicelines, pills, cards, souls, and your parents arguing are all turned into TTS voices.6.8k downloadsupdated 20 mo ago
Narrador Loquendoby 76561199123158034Este mod es para actualizar y rehacer el mod del narrador loquendo ya que no lo actualizan hace bastante tiempo Hasta ahora he cambiado 38 lineas de voz. Mi intencion es cambiar todos o la mayoria de dialogos del juego. Si tienen ideas pueden escribirlas y probablemente las ponga El mod original...6.6k downloadsupdated 2 mo ago
Miku Anouncer Modby 76561199376393245Changes all announcer dialogue into Hatsune Miku V4! Horse piills are reverbed, both because I'm lazy, and because i think it sounds nice. reverse cards are... well yeah that one was easy enough I did *some* testing, but let me know if there are any sounds where i messed the file names up (they'l...6.6k downloadsupdated 20 mo ago
Godmode汉化模组by 76561199253021281⚠️该模组已过期，请在我的合集里下载新的EID汉化模组⚠️ 这是一个对Godmode Achieved模组的EID进行了汉化的模组请确认你已安装了Godmode Achieved和EID 汉化作者：B站@青灼QWQ 感谢B站@长山小春0213 提供的汉化帮助6.4k downloadsupdated 23 mo ago
You Little Fücker - The Pillby ViscerAI made a shit of piece with my trash mod6.3k downloadsupdated 5 y ago
NLSS Memes Itempackby DrakonnasAdds NLSS themed items to the game! So far this mod includes 43 all new items, 2 new trinkets and 2 new pill effects! Feedback / bug reports are always appreciated! If you want easy access to all new items, there's a variable called PREVIEW_ITEMS at the top of the main.lua file. Just turn that va...6.2k downloadsupdated 9 y ago
shuaner's respritesby shuanerthis is a resprties mod changed: some items（50%+） item costumes trinkets pickups cards, pills, slots monsters bosses etc Continuously updated6.2k downloadsupdated 6 mo ago
The Neapolitan Packby PixelPlz13* new items have appeared in the Basement! The Neapolitan Pack adds a collection of sweet items to spice up your runs! These items are... Item: Description: Found in: Cinnamon Gumball Don't swallow it. Hwa-poo! Treasure Rooms Rad Roach Multiplies under stress. Toxic species. Treasure Rooms Faus...6.0k downloadsupdated 9 mo ago
Cursed Voiceoversby SprSnpr_I edited some voiceover lines to make them . . . cursed All voiceovers have been changed-- outside of cutscenes, naturally All new voiceovers were made using preexisting ones6.0k downloadsupdated 5 y ago
Lootboxesby SwiftStriker00Introduction The intent is to provide players with a sense of pride and accomplishment for acquiring different items. As for cost, I selected initial values based upon data from the main game and other adjustments made to gate off rewards before launch. Among other things, I’m looking at average...5.8k downloadsupdated 9 y ago
PLACENTA+by VerlyonDernière MàJ : 13.12.2019 : v1.1 Les voix ont été ajoutées automatiquement! Ce qu'il reste à faire : - Toutes les cartes "XXX appeared in the basement"; - Certains titres ne fonctionnent pas proprement au niveau des accents; - Quelques menus du départ, dont le bestiaire; - La voix de l'intro. Il...5.6k downloadsupdated 5 y ago
Co-Op Commands!by MINDS3TThis mod adds a set of commands that allow you to add and remove items from any player currently in the game. The two commands: giveplayer (aliases givep, gplayer, gp) Usage: gp <player_id> <item_id> <count> Gives the specified player the item, count amount of times. item_id works with anything y...5.5k downloadsupdated 5 y ago
The Serpent (+24 Unlocks)by Kerkel2 New Characters Have Appeared in the Basement! The Serpent aims to spice up the normal Isaac formula by making the player choose between 1 of 3 unique Blessings and 1 of 3 unique Sins upon starting a run. Blessings grant a modest benefit to help you along, and Sins provide a strong negative effe...5.4k downloadsupdated 1 mo ago
[BETA] Isaac Rebalancedby 76561198412573006Requires REPENTOGON! For more information, visit This mod is in BETA and is unfinished! Some bugs may be present! Isaac Rebalanced is a mod which changes many aspects of the game with the goal of making it feel more fair and fun to play. These aspects include... Item Changes Many useless and bori...5.4k downloadsupdated 2 y ago
Chills as the announcerby e?Sorry. Made with Uberduck. Some of the voice clips may sound a bit funky (e.g. Hematemesis, Ehwaz). If any of the voice clips is not the right one or is just white noise let me know.5.3k downloadsupdated 5 y ago
D18by bethanw10Repentance Compatible Because what The Binding of Isaac really needs is another dice. Rerolls coins into other coins, chests into other chests, hearts into other hearts, pill into other pills, and cards and runes into other cards and runes. Reroll is based on the same chances as normal pickup dro...5.3k downloadsupdated 5 y ago
NE MARCHE PLUS Le Binding Of Isaac Afterbirth+ French Versionby 76561198053733721Dernière MàJ: 01.01.17: v0.5 Grâce à la grande aide de FireInTheHope ( ), la traduction est quasiment finie! il ne reste plus que les bébés Co-op et le menu à traduire! Bonjour à tous! Je vous présente mon mod appelé Le Binding of Isaac! Je vais commencer par faire une traduction complète du jeu...5.2k downloadsupdated 9 y ago
Prescription Pills Packby Tim l'enchanteurAdd pills effects from the Medical Prescription mod witout the associated passive items. /!\ Do not activate both mods at the same time as Pills Effects have the same name Currently include 15 pills : Red Is Blue : Switch red hearts and soul hearts Gold Fever : Midas effect on enemies in the room...5.2k downloadsupdated 10 y ago
[REP/REP+]Glacier's Laboratoryby Red.16Just some random, wacky, and maybe unique stuff I make from time to time. Currently, the mod has: -4 characters -100+ items -20+ trinkets -13 pocket items -4 pills -Some new rooms Feel free to try it and leave a comment!5.2k downloadsupdated 18 d ago
Edith Restoredby BrakeDude"But Lot's wife looked back, and she became a pillar of salt." - Genesis 19:26 The unused secret character from Antibirth has been restored and improved, with updated gameplay for Repentance! Features 1 new character unlocked by defeating The Beast. 14 unlocks for Edith's completion marks. Custom...5.0k downloadsupdated 18 d ago
Horsier Horse Pills™by SprSnpr_Say 'neigh' to boring horse pills! I've spruced up the horse pill sound effect with some equine nonsense.4.7k downloadsupdated 5 y ago
Sonic Mod [Beta]by Ao JonesiUPDATE: Thank you so much to everyone for checking out my mod! We've nearly hit 500 subscribers, and I'm working on an update that should finish Tails and properly fix Sky Sanctuary asap, along with other awesome features! Introducing the Sonic Mod, a creation made in my spare time as a love lett...4.6k downloadsupdated 9 y ago
[REP/REP+] Armoniel (22 Unlocks!)by heehooWARNING: THIS VERSION IS FOR REPENTANCE ONLY. FOR THE AFTERBIRTH+ VERSION, CLICK HERE: AB+ Version DO NOT USE THIS MOD ALONGSIDE ANY OTHER ARMONIEL MODS. OTHER REPENTANCE ARMONIEL MODS: - Just the new items, no unlocking required! - Just Armoniel (+ Tainted Armoniel) and the new challenge - Just...4.6k downloadsupdated 18 mo ago
Gunpowder Pillby ☢ Nato Potato ☢The gunpowder pill grants the pyromaniac effect for the current room and causes an explosion around the player. Use it in a pinch to kill the enemies around you and heal 1 heart, or when fighting against an enemy that uses explosions like Sloth, or just to hit a tinted rock or to spend a bomb or...4.6k downloadsupdated 4 y ago
Drop/Swap Button Reworkedby 76561199032508689Have to keep holding CTRL for 5 seconds to drop trinkets or cards? Annoyed when playing as The Forgotten and have to press CTRL twice to swap active items? This mod allows you to drop your trinkets or cards faster by pressing only one button, and swap active by pressing the ALT key. By default Y...4.6k downloadsupdated 4 y ago
Better Starting Itemsby Lemon MeringuinEdits character starting items to give a stronger start without being too overpowered. Each character has items suited towards their playstyle and backstory. Isaac: Trinket - NO! (Synergizes with D6) Magdalene: Mom's Lipstick, Guardian Angel Cain: PHD (To simulate the playstyle of oldschool Cain)...4.5k downloadsupdated 9 y ago
SacredDreams EID汉化by 76561199253021281SacredDreams的EID汉化模组汉化作者：B站@青灼QWQ4.4k downloadsupdated 2 y ago
Explosive Diarrhea Shittsing Editionby ChickenfayceI changed the Explosive Diarrhea pill sound and horse pill version to a voice over a user did of a comic I love dearly Original comic: Voice dub Audio:4.4k downloadsupdated 5 y ago
D666by micromarioDescription: Reroll your soul Itempools: Treasure and devil Effects: (Active) If you have red health, the item takes two hearts away and gives you a random devil deal item If you have soul health, the item takes three hearts away and gives you a random devil deal item If you don't have health, th...4.3k downloadsupdated 10 y ago
Tung Tung Devil replaces Satanby 76561199311872895dont worry hes with tung now TUNG TUNG DEVIL REPLACES SATAN only replaces statue, not boss sorry not sorry maybe if this gets on front page of workshop ill consider it winkwinkwinkwinkwink tung tung god here:4.2k downloadsupdated 5 mo ago
Isaac Ukranian 0.2vby DemabelThe Binding of Isaac Українською 1.0 v ВАЖЛИВА ІНФОРМАЦІЯ!! Дана українізація адаптована під англомовну версію гри, перед завантаженням перемкніть на неї, якщо використовуєте іншу. Крім того не забувайте щоб отримувати оновлення, вам треба повністю видалити папку з модом, зайти в гру. Скачати йог...4.2k downloadsupdated 3 y ago
ADHDby The Australian King Of ArrowsA simple little mod pack that gives you a new item and a new pill: Items: * ADHD - Get a massive speed boost, however you get a constant slight shaking to your character. Can't stop, won't stop. Pills: Ritalin - Give's you a small speed boost. However if you have picked up ADHD, then this pill gi...4.2k downloadsupdated 10 y ago
Syringes! A New Consumable [Afterbirth+ Only]by AgentCuccoA brand new type of consumable! - Syringes behave similar to pills, they give temporary buffs or debuffs to the players, and they are undiscovered until used for the first time. - At the beginning of a run, a pool of 13 random syringes is determined for the rest of the run. - Syringes have a 33%...4.1k downloadsupdated 6 y ago

The Binding of Isaac: Rebirth pills mods, page 3