Mods / pills

• FFaith's Rewardby DaGammlaDo you have a bad Computer? Do the fireworks produce lag? Just press "F1" and you're save! CAUTION ! This mod is possibly not compatible with others but Works perfectly with True Co-op Content : --Dynamic Boss drops-- Bosses have a chance to spawn Boss specific items like Mask of Infamy -> Isaac'...8.3k downloadsupdated 8 y ago
• NNo Useless Heartsby Iris HeartThis mod makes every base game character able to pick up and utilize any base game heart! Details below. This mod is a mainly a compilation mod of my other smaller mods that are aimed at individual characters, except for Blue Baby who doesn't have his own separate mod by me, because such mod exis...8.1k downloadsupdated 4 y ago
• TThe Binding of Brazil (AB+)by TCDubs✎ 𝗥𝗲𝗽𝗲𝗻𝘁𝗮𝗻𝗰𝗲: --------------- A Tradução Brasileira de "The Binding of Isaac: Afterbirth +" ~Todos os Itens e Suas Próprias Descrições ~Pílulas, Cartas, Runas e Suas Descrições ~Alguns Nomes de Bosses ~Os Desafios ~O Bestiário ~Interface ~Todas as Conquistas ~Booster Pack 1,2,3,4 e 5 ~Andares ~ S...8.0k downloadsupdated 8 y ago
• Bbuwenby 76561198347365682=BuWen Mod= 【Mod内容】 ①共计580 左右新的道具。 ②30位新角色（15表角色+15里角色） ③7种mod特有角色属性(基础攻击力、暴击率、暴击伤害、攻击力加成、最终伤害、技能加成、冷却缩减) ④34种“精英技能”；全新机制，怪物生成时有概率被赋予随机技能效果，每个“精英技能”有着各自各样的效果 ⑤12种“精英怪物”；全新怪物，不同怪物有着自己的攻击方式以及特殊机制。 ⑥添加伤害飘字显示，反馈拉满。 ⑦35 种以上新的卡牌、32 种以上新的药水效果、新的8种套装效果。 ⑧空想神话装备体系（完美还原崩崩，膨胀的开始） ⑨难度选择机制，可更具游戏进程和发育情况修改难度。以及...7.9k downloadsupdated 7 d ago
• BBetter Retro Visionby slapjakChanges the Retro Vision pill voice line to be bitcrushed. I always thought it should be like this. Now with horse pill support.7.7k downloadsupdated 5 y ago
• !! 한국어 2 (Korean 2)by 76561198448763048구독자 1,700명 감사합니다. 이 모드를 적용하고 나서, 설정에서 언어를 한국어로 바꾸셔야 아이템 이름 등이 제대로 보여요. 이 모드를 적용하고 나서, 설정에서 언어를 한국어로 바꾸셔야 아이템 이름 등이 제대로 보여요. 사진처럼 몇몇 아이템의 이름과 설명이 살짝 바뀌고 번역 오류를 수정해 주는 모드입니다. 번역 오류랑 상관없이 그냥 (아이템의 이름이나 설명이) 바뀐 것들도 있는데, 이 모드가 한국어 파일에서 번역 오류를 찾아서 수정한 게 아니라 그냥 영어 파일을 한국어로 번역한 거라서 그런 거예요. 그리고 가끔 이상한 드립...7.7k downloadsupdated 3 y ago
• CCobson (Beast resprite)by 76561198338773226HWABAG Bone chilling, spine tingling, genre redefining, slow-burn resprite mod that will change The Beast with Cobson. no 'p embedded.7.7k downloadsupdated 3 y ago
• NNeco Arc voiceoverby 76561198338773226Changes the narrator voice to Neco-Arc voice. All voiceovers have been changed by using AI.7.6k downloadsupdated 3 y ago
• SSyringes+by NyxreThe Syringes+ Mod adds a variety of different Syringe based items to the item pool. Future updates will add more items, pills, and a new character. Current Item List: Passives: - Used Needle (Reduces Fire Delay) - Morphine (Reduces Speed, Gives 2 Spirit Hearts) - Booster Shot (Increases Speed, In...7.5k downloadsupdated 10 y ago
• GGamblecore "I Can't Stop Winning!" Over Good Pillsby LulledNullreplaces various sound effects with "I can't stop winning!" and "Let's be financially responsible!" List of the different sounds replaced: "I can't stop winning!": Good Pills Winning slots "Let's be financially responsible!": Credit Card Temperance Soul of The Keeper Ace of Diamonds 2 of Diamonds...7.4k downloadsupdated 2 y ago
• NNarrador Loquendoby 76561199123158034Este mod es para actualizar y rehacer el mod del narrador loquendo ya que no lo actualizan hace bastante tiempo Hasta ahora he cambiado 40 lineas de voz. Mi intencion es cambiar todos o la mayoria de dialogos del juego. Si tienen ideas pueden escribirlas y probablemente las ponga El mod original...7.3k downloadsupdated 2 mo ago
• !!Astro-rulesby 허농이한국어 설명은 하단에 있습니다! Please Note This. This mod was implemented for the personal streaming. Therefore, It may be inappropriate for general runs. Also, we cannot guarantee the compatibility with other mods. Introduction Redrawn Mod was developed for TBoI: Time Attack Race, which is one of the content...7.1k downloadsupdated 7 d ago
• TTikTok Lady Narratorby MightyKingWarioMakes The Binding of Isaac worse. Replaces all narrator lines from the base game into the terrible quirky TikTok lady. All voicelines, pills, cards, souls, and your parents arguing are all turned into TTS voices.7.1k downloadsupdated 21 mo ago
• IIsaac Reforged [Afterbirth+]by KaliThis mod aims to add and rebalance characters, synergies, and transformations, while remaining faithful to the vanilla experience. Supports External Item Descriptions! Supports Mod Config Menu! Supports Revelations! Supports Fiend Folio! & More! All changes are configurable with the Mod Config Me...7.0k downloadsupdated 6 y ago
• MMiku Anouncer Modby 76561199376393245Changes all announcer dialogue into Hatsune Miku V4! Horse piills are reverbed, both because I'm lazy, and because i think it sounds nice. reverse cards are... well yeah that one was easy enough I did *some* testing, but let me know if there are any sounds where i messed the file names up (they'l...7.0k downloadsupdated 21 mo ago
• GGodmode汉化模组by 76561199253021281⚠️该模组已过期，请在我的合集里下载新的EID汉化模组⚠️ 这是一个对Godmode Achieved模组的EID进行了汉化的模组 请确认你已安装了Godmode Achieved和EID 汉化作者：B站@青灼QWQ 感谢B站@长山小春0213 提供的汉化帮助6.4k downloadsupdated 2 y ago
• YYou Little Fücker - The Pillby ViscerAI made a shit of piece with my trash mod6.4k downloadsupdated 5 y ago
• Sshuaner's respritesby shuanerthis is a resprties mod changed: some items（50%+） item costumes trinkets pickups cards, pills, slots monsters bosses etc Continuously updated6.4k downloadsupdated 8 mo ago
• TThe Neapolitan Packby PixelPlz13* new items have appeared in the Basement! The Neapolitan Pack adds a collection of sweet items to spice up your runs! These items are... Item: Description: Found in: Cinnamon Gumball Don't swallow it. Hwa-poo! Treasure Rooms Rad Roach Multiplies under stress. Toxic species. Treasure Rooms Faus...6.4k downloadsupdated 11 mo ago
• NNLSS Memes Itempackby DrakonnasAdds NLSS themed items to the game! So far this mod includes 43 all new items, 2 new trinkets and 2 new pill effects! Feedback / bug reports are always appreciated! If you want easy access to all new items, there's a variable called PREVIEW_ITEMS at the top of the main.lua file. Just turn that va...6.3k downloadsupdated 10 y ago
• CCursed Voiceoversby SprSnpr_I edited some voiceover lines to make them . . . cursed All voiceovers have been changed-- outside of cutscenes, naturally All new voiceovers were made using preexisting ones6.0k downloadsupdated 5 y ago
• TThe Serpent (+24 Unlocks)by Kerkel2 New Characters Have Appeared in the Basement! The Serpent aims to spice up the normal Isaac formula by making the player choose between 1 of 3 unique Blessings and 1 of 3 unique Sins upon starting a run. Blessings grant a modest benefit to help you along, and Sins provide a strong negative effe...5.8k downloadsupdated 3 mo ago
• LLootboxesby SwiftStriker00Introduction The intent is to provide players with a sense of pride and accomplishment for acquiring different items. As for cost, I selected initial values based upon data from the main game and other adjustments made to gate off rewards before launch. Among other things, I’m looking at average...5.8k downloadsupdated 9 y ago
• PPLACENTA+by VerlyonDernière MàJ : 13.12.2019 : v1.1 Les voix ont été ajoutées automatiquement! Ce qu'il reste à faire : - Toutes les cartes "XXX appeared in the basement"; - Certains titres ne fonctionnent pas proprement au niveau des accents; - Quelques menus du départ, dont le bestiaire; - La voix de l'intro. Il...5.7k downloadsupdated 5 y ago
• [[BETA] Isaac Rebalancedby 76561198412573006Requires REPENTOGON! For more information, visit This mod is in BETA and is unfinished! Some bugs may be present! Isaac Rebalanced is a mod which changes many aspects of the game with the goal of making it feel more fair and fun to play. These aspects include... Item Changes Many useless and bori...5.7k downloadsupdated 2 y ago
• [[REP/REP+]Glacier's Laboratoryby Red.16Just some random, wacky, and maybe unique stuff I make from time to time. Currently, the mod has: -4 characters -100+ items -20+ trinkets -13 pocket items -4 pills -Some new rooms Feel free to try it and leave a comment!5.7k downloadsupdated 8 d ago
• CCo-Op Commands!by MINDS3TThis mod adds a set of commands that allow you to add and remove items from any player currently in the game. The two commands: giveplayer (aliases givep, gplayer, gp) Usage: gp <player_id> <item_id> <count> Gives the specified player the item, count amount of times. item_id works with anything y...5.7k downloadsupdated 5 y ago
• EEdith Restoredby BrakeDude"But Lot's wife looked back, and she became a pillar of salt." - Genesis 19:26 The unused secret character from Antibirth has been restored and improved, with updated gameplay for Repentance! Features 1 new character unlocked by defeating The Beast. 14 unlocks for Edith's completion marks. Custom...5.4k downloadsupdated 2 mo ago
• CChills as the announcerby e?Sorry. Made with Uberduck. Some of the voice clips may sound a bit funky (e.g. Hematemesis, Ehwaz). If any of the voice clips is not the right one or is just white noise let me know.5.4k downloadsupdated 5 y ago
• DD18by bethanw10Repentance Compatible Because what The Binding of Isaac really needs is another dice. Rerolls coins into other coins, chests into other chests, hearts into other hearts, pill into other pills, and cards and runes into other cards and runes. Reroll is based on the same chances as normal pickup dro...5.3k downloadsupdated 5 y ago
• NNE MARCHE PLUS Le Binding Of Isaac Afterbirth+ French Versionby 76561198053733721Dernière MàJ: 01.01.17: v0.5 Grâce à la grande aide de FireInTheHope ( ), la traduction est quasiment finie! il ne reste plus que les bébés Co-op et le menu à traduire! Bonjour à tous! Je vous présente mon mod appelé Le Binding of Isaac! Je vais commencer par faire une traduction complète du jeu...5.3k downloadsupdated 9 y ago
• PPrescription Pills Packby Tim l'enchanteurAdd pills effects from the Medical Prescription mod witout the associated passive items. /!\ Do not activate both mods at the same time as Pills Effects have the same name Currently include 15 pills : Red Is Blue : Switch red hearts and soul hearts Gold Fever : Midas effect on enemies in the room...5.2k downloadsupdated 10 y ago
• HHorsier Horse Pills™by SprSnpr_Say 'neigh' to boring horse pills! I've spruced up the horse pill sound effect with some equine nonsense.4.8k downloadsupdated 5 y ago
• DDrop/Swap Button Reworkedby 76561199032508689Have to keep holding CTRL for 5 seconds to drop trinkets or cards? Annoyed when playing as The Forgotten and have to press CTRL twice to swap active items? This mod allows you to drop your trinkets or cards faster by pressing only one button, and swap active by pressing the ALT key. By default Y...4.8k downloadsupdated 4 y ago
• [[REP/REP+] Armoniel (22 Unlocks!)by heehooWARNING: THIS VERSION IS FOR REPENTANCE ONLY. FOR THE AFTERBIRTH+ VERSION, CLICK HERE: AB+ Version DO NOT USE THIS MOD ALONGSIDE ANY OTHER ARMONIEL MODS. OTHER REPENTANCE ARMONIEL MODS: - Just the new items, no unlocking required! - Just Armoniel (+ Tainted Armoniel) and the new challenge - Just...4.7k downloadsupdated 20 mo ago
• SSonic Mod [Beta]by Ao JonesiUPDATE: Thank you so much to everyone for checking out my mod! We've nearly hit 500 subscribers, and I'm working on an update that should finish Tails and properly fix Sky Sanctuary asap, along with other awesome features! Introducing the Sonic Mod, a creation made in my spare time as a love lett...4.7k downloadsupdated 9 y ago
• GGunpowder Pillby ☢ Nato Potato ☢The gunpowder pill grants the pyromaniac effect for the current room and causes an explosion around the player. Use it in a pinch to kill the enemies around you and heal 1 heart, or when fighting against an enemy that uses explosions like Sloth, or just to hit a tinted rock or to spend a bomb or...4.6k downloadsupdated 4 y ago
• SSacredDreams EID汉化by 76561199253021281SacredDreams的EID汉化模组 汉化作者：B站@青灼QWQ4.6k downloadsupdated 2 y ago
• BBetter Starting Itemsby Lemon MeringuinEdits character starting items to give a stronger start without being too overpowered. Each character has items suited towards their playstyle and backstory. Isaac: Trinket - NO! (Synergizes with D6) Magdalene: Mom's Lipstick, Guardian Angel Cain: PHD (To simulate the playstyle of oldschool Cain)...4.6k downloadsupdated 9 y ago
• TTung Tung Devil replaces Satanby 76561199311872895dont worry hes with tung now TUNG TUNG DEVIL REPLACES SATAN only replaces statue, not boss sorry not sorry maybe if this gets on front page of workshop ill consider it winkwinkwinkwinkwink tung tung god here:4.6k downloadsupdated 7 mo ago
• EExplosive Diarrhea Shittsing Editionby ChickenfayceI changed the Explosive Diarrhea pill sound and horse pill version to a voice over a user did of a comic I love dearly Original comic: Voice dub Audio:4.4k downloadsupdated 5 y ago
• IIsaac Ukranian 0.2vby DemabelThe Binding of Isaac Українською 1.0 v ВАЖЛИВА ІНФОРМАЦІЯ!! Дана українізація адаптована під англомовну версію гри, перед завантаженням перемкніть на неї, якщо використовуєте іншу. Крім того не забувайте щоб отримувати оновлення, вам треба повністю видалити папку з модом, зайти в гру. Скачати йог...4.4k downloadsupdated 3 y ago
• DD666by micromarioDescription: Reroll your soul Itempools: Treasure and devil Effects: (Active) If you have red health, the item takes two hearts away and gives you a random devil deal item If you have soul health, the item takes three hearts away and gives you a random devil deal item If you don't have health, th...4.3k downloadsupdated 10 y ago
• [[REP+] Always Restockby 76561199164471930Now there is always a restock machine in the shop This mod ensures that you will always find a restock machine in shops, both in normal mode and in Greed Mode. The restock machine is automatically generated in all shops and adapts by adjusting its position when you play as the Tainted Keeper.4.3k downloadsupdated 9 mo ago
• AADHDby The Australian King Of ArrowsA simple little mod pack that gives you a new item and a new pill: Items: * ADHD - Get a massive speed boost, however you get a constant slight shaking to your character. Can't stop, won't stop. Pills: Ritalin - Give's you a small speed boost. However if you have picked up ADHD, then this pill gi...4.2k downloadsupdated 10 y ago
• TTerraria teksturaby AsukaМод меняет предметы Айзека на предметы террарии The mod changes Isaac's items to terraria items The mod changes 176 items Over 56 familiars Over 240 costumes (from over 50 different items) 6 transformations Keys, bombs, coins All hearts 15 trinket Redrawn all tarot cards and inverted tarot cards...4.2k downloadsupdated 3 y ago
• VVine boom over bad pillby 76561199103243331funy download ples4.1k downloadsupdated 3 y ago
• SSyringes! A New Consumable [Afterbirth+ Only]by AgentCuccoA brand new type of consumable! - Syringes behave similar to pills, they give temporary buffs or debuffs to the players, and they are undiscovered until used for the first time. - At the beginning of a run, a pool of 13 random syringes is determined for the rest of the run. - Syringes have a 33%...4.1k downloadsupdated 6 y ago

155 pills mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.