The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth tweaks mods
Everything filed under tweaks by its own author, ordered by how much it is used.
1,627 tweaks mods, most downloaded first · newest update 29 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
1.6k tweaks mods
- fiber optic isaac core (markiplier lobotomy mod)by 76561199121244854Hello everybody my name is Welcome what this mod does: - Markiplier welcomes you to the Home floor - Markiplier comments on your nightmare in your mom's bed (provided you don't skip the cutscene) - IF DOGMA IS COMING RIGHT NOW LET ME SEE IT! LET ME SEE IT! SHOW ME!!! - changes music on the home f...8.8k downloadsupdated 3 y ago
- EXPLODING PLUM (100% Chance)by 76561199087673261restores the 100% chance of baby plum exploding to death FUCK BABY PLUM!!!!!!!!!!!!!!!!!!!!!!118.7k downloadsupdated 4 y ago
- More Treasure - Better Co-op!by BigrojobearPlay co-op with your friends and don't get item starved. Extra items have been added to treasure rooms, planetariums, boss rush, angel rooms, devil rooms with some other bonuses along the way.8.7k downloadsupdated 5 y ago
- The dark closet (dark room reskin)by 765611989411998398.7k downloadsupdated 2 y ago
- Item Icons on Character Selectby 76561198375403876A quick mod to replace the icons on the character select screen with the actual item icons. Might require a game restart to fully apply the changes Not compatibl with other mods that edit the character select screen8.7k downloadsupdated 4 y ago
- Streak Helperby 76561198447262219Meet the "Streak Helper!" This mod combines 3 mods: Destination indicator, Seed on Screen and Boss Rush Wave Counter But not only that! It also adds an icon of your starting character on the screen and your streak value! And you can configure everything in Mod Config Menu! You can change the posi...8.7k downloadsupdated 14 mo ago
- Auto-Pickup Coins in Greed Modeby kittenchillyAutomatically picks up any coins that would spawn at the end of a Greed Mode wave! Also automatically heals the Keeper.8.7k downloadsupdated 5 y ago
- Hotter Minesby catinsuranceThis mod makes it so any room with lava in it applies a "heat wave" shader to the screen. It's the movement you see in the air when it's really, really hot! In vanilla Isaac, only certain rooms in the Mines stage have lava. Be warned that this isn't in the vanilla game for a reason! Some people m...8.6k downloadsupdated 4 y ago
- Detailed Reminder Marksby 76561199514285779Cooler marks&Reminder marks now combined! Looks very simple and easily readable. Great for any new player who is yet to memorise every check-mark Made by Slushy8.6k downloadsupdated 5 mo ago
- Item Pool Rework Modby Dr. Monty(If you have any questions about this mod, check out the QNA under the description!) Does walking into a devil deal, only to see Multidimensional Baby and We Need to Go Deeper, give you clinical depression? Are you sick of seeing items like Duality and Mom’s Coin Purse appearing way more often th...8.6k downloadsupdated 3 y ago
- Balanced Starter Choicesby 76561199114159195Tired of walking into your very first Treasure Room and getting stuck with a single random item? Balanced Starter Choices replaces the lone starting pedestal with a configurable set of item choices, just like the "There's Options" pickups — pick one, and the rest vanish. WHAT IT DOES - On your fi...8.6k downloadsupdated 3 mo ago
- restart on controllerby r0_0tDid you ever wish you could restart / quick reset from your controller / gamepad? Worry not, just pull both triggers on your xbox controller and be happy! To be precise, this mod restarts / quick resets the game when you hold down the key to use items and the key to drop your stuff for about the...8.6k downloadsupdated 9 y ago
- Better Mausoleum Backdropby PixelPlzUSE MY NEW MOD INSTEAD Makes the Mausoleum look the way it was in Antibirth in the submap for the 3rd knife piece. (Achieved by simply changing one number in the "stages.xml" file)8.6k downloadsupdated 6 y ago
- Unique chest poolsby zzzzzzzzUnique Chest Pools This mod changes the item pools of the stone and eternal chests to make them feel more unique and interesting. The stone chest pool contains all sorts of stone and rock related items. The eternal chest pool contains items that are related to/give you eternal hearts and revival...8.6k downloadsupdated 4 y ago
- Tweaked Duality spriteby ViscerATweaked sprite for Duality. It doesn't change the costume, but if that is something you'd like to see, don't hesitate to let me know! Make sure to leave your feedback in the comments, and don't hesitate to recommend any other sprite tweaks you would like to see from me in the future! For your con...8.6k downloadsupdated 6 y ago
- Start with C Sectionby BarjuhStart each run with C Section Collection with all my Start with mods :8.6k downloadsupdated 4 y ago
- Always Opened Secret Roomsby Joe BidenAlways opened secret rooms by starting with X-ray vision.8.5k downloadsupdated 5 y ago
- Less Broken Mineshaftby StlkngneWalking down the mineshaft to get to Knife Piece 2 is boring. Now, you can ride the minecart all the way in. You'll still have to fight your way out. Note: you can skip the minecart ride by bombing your way in. Support for the following mods has been added: Fall from Grace (Grotto) Fiend Folio Re...8.5k downloadsupdated 2 mo ago
- Eden For Free!by SprSnpr_Adds a custom challenge that allows you to play as Eden regardless of how many tokens you may or may not have. The only downsides are that you have no choice but to go to The Chest and it doesn't save you win streak. Feedback and ratings are much appreciated!8.5k downloadsupdated 6 y ago
- Candle Indicatorby 76561199049581887a mod to indicate the 5 levels of the item Paschal Candle, enjoy8.5k downloadsupdated 3 y ago
- Angels drop items in Greed Modeby 76561199022951369Ever thought how useless key pieces were in Greed Mode? Well, I have too! This mod is pretty simple, making it so Uriel and Gabriel drop normal items instead of key pieces in Greed Mode. Also works with the Devil Keys mod!8.5k downloadsupdated 4 mo ago
- better crowns 2.0by 76561198876704734this is an improved version of a previous mod I've made, now containing slightly improved sprites and diamond tears for Dark Prince's Crown baked in.8.5k downloadsupdated 4 y ago
- Character Based Soundtracksby ☢ Nato Potato ☢This mod is an add-on for the Soundtrack Menu mod that allows you to have a separate music setting for each character (one setting for modded characters) by using the Mod Config Menu. If you want different characters to have different "Custom" soundtracks and don't mind doing a little lua editing...8.5k downloadsupdated 9 mo ago
- True Random Character Selectionby U.P.STrue Random Selection Mod This mod adds a new option in the character selection menu that will select a random character from the regular and tainted character pool! The random character you get is determined by the run's seed allowing you to relive your favorite runs without worrying about getti...8.5k downloadsupdated 3 y ago
- SANS is forgottenby 76561199213409599ee e e e e e e e e e8.5k downloadsupdated 3 y ago
- Trollirium (Troll Face Delirium)by Squizzle DizzleThis mod replaces Delirium with the Troll Face Based on8.5k downloadsupdated 10 mo ago
- [Ab+ Only] Complete Eternal Edition+by GuilhermeTHIS MOD IS OUTDATED, Click Here FOR THE REPENTANCE VERSION This mod adds a new champion variant for almost all monsters and for all bosses, all based on the classic game. Eternal enemies are tougher and haves new mechanics, with a small chance of dropping a reward. ATTENTION • Incompatible with:...8.5k downloadsupdated 4 y ago
- !!!Screen Animations APIby 76561199034036813Hello everyone and welcome to my Api! This api was originally made as a module for my upcoming mod. However, after some deliberation, I decided to release it as a standalone api, for all to use! So, what does this api allow? It allows you to easily play, Giantbook animations, Achievements, and Ni...8.5k downloadsupdated 3 y ago
- [REUPLOAD] Aladar's Mushroom Items Respriteby 76561198391425301Aladar, one of the, if not the best, spriter of Isaac has left internet, making his profile private and removing all the mods and amazing sprites and resprites he has done, sadly. I have a backup of most of the mods he had, and I'm reuploading them for the people who liked them, to still be able...8.4k downloadsupdated 17 mo ago
- Shamrock Malphite Over Gnawed Leafby Adadmek8.4k downloadsupdated 21 mo ago
- Locust APIby im_temThis is an API for adding custom effects to locusts. You can use it to get mind boggling effects! This mod does NOT provide anything on its own but I have released effect pack for this API (Locust Pack). Have fun!8.4k downloadsupdated 5 y ago
- Dataminer Descriptions CNby 76561198811272757为数据破解生成的错误道具显示中文效果描述,基于 EID 中文数据库优化显示。8.4k downloadsupdated 4 mo ago
- Neko Kinetiby 76561198811060732As per request, a new addition to the neko family, the annoying, but now adorable bane of every Mausoleum run, kineti. What other monsters should be made into their cat / neko versions?8.4k downloadsupdated 5 y ago
- Lost Keeps Holy Mantle [AB+ only]by stickfight2This is a simple mod but one I really like. The Lost bothered me - his starting items don't really work well together, so I've improved that. Now the Lost will always have the holy mantle, even when rerolling. When rerolling, a random passive item will be removed immediately and replaced with hol...8.4k downloadsupdated 9 y ago
- Postal Dude Pill Voice Packby Flubber Johnny𝐈 𝐠𝐨𝐭𝐭𝐚 𝐬𝐭𝐨𝐩 𝐬𝐦𝐨𝐤𝐢𝐧𝐠 𝐭𝐡𝐢𝐬 𝐜𝐫𝐚𝐩 Replaces all 48 pill sounds with voice lines of the Postal Dude from Postal 2 𝐍𝐨𝐭𝐞𝐬 - horse pills currently don't have any lines - no voice lines for cards or runes8.4k downloadsupdated 3 y ago
- Faith's Rewardby DaGammlaDo you have a bad Computer? Do the fireworks produce lag? Just press "F1" and you're save! CAUTION ! This mod is possibly not compatible with others but Works perfectly with True Co-op Content : --Dynamic Boss drops-- Bosses have a chance to spawn Boss specific items like Mask of Infamy -> Isaac'...8.3k downloadsupdated 8 y ago
- Ohyo - Character & +15 New Items [AB+]by AgentCuccoA brand new and unique character! Use your Blood Gauge to store red hearts and use them as charges, as well as becoming a sharpshooter to land critical hits on enemies. Use over 15 brand new items to help you traverse the basement! THIS MOD IS UNTESTED IN REPENTANCE Features: - A brand new and un...8.3k downloadsupdated 6 y ago
- Make Gimpy Awfulby 765611989816467688.3k downloadsupdated 5 y ago
- Alt Path + Mother in Greed Mode!by 76561199034036813With the 1 year anniversary of Planetariums in Greed Mode coming up, I knew I had to return to my roots and make another greed mode mod. So, I present to you: The Alt Path in Greed Mode! Yes, I know this has been done before (twice in fact) but the original mod had 3 main problems that this mod f...8.3k downloadsupdated 4 y ago
- [OBSOLETE] Centered Planetarium Door Fixby HiddenAs of patch 1.7.8, the door has been centered and therefore this mod is obsolete. Thank you for using it! -- Old Description -- This mod centers the orb on top of planetarium doors since they weren't aligned somehow. The thumbail took more effort and time to do than the mod and that took me 5 min...8.2k downloadsupdated 5 y ago
- dogma dumpyby watchmeojoever thought dogma's glitching when it's at low hp was too...normal? now here is it improved, with dogma's massive dumpy shaking in your face sprite adaptation made by me of NeonVanta's original isaac dumpy gif8.2k downloadsupdated 4 y ago
- Visible Tears! [REP]by Lucky🌟THE CODE OF THIS MOD WAS NOT MADE BY ME The code of this mod was made by: @Xalum and @oatmealine from the "Modding of Isaac" Discord server that you should 100% join! The code was also changed and polished by a User that goes by the name of @Nami on the Discord server "Modding of Isaac" Without t...8.2k downloadsupdated 5 y ago
- Rainbow Poop Gives Tainted Lost Holy Card Effectby 76561198995475535This mod makes it so destroying a rainbow poop as tainted lost gives you a holy mantle effect. (Like it uses the card and gives the mantle it doesn't drop a card or something) Inspired by mods Tainted Lost can Rest and Rainbow Poop Gives a Soul Heart !8.2k downloadsupdated 4 y ago
- YAPO (Yet Another Portrait Overhaul)by FerrySimple enough I wanted to redo some boss portraits, I went for something cute for the cute bosses while I went for some more detail for the not as cute bosses, some exceptions here and there and they might be subject to change in the future. Check em' at the images, there's 24 now! More to come i...8.1k downloadsupdated 5 y ago
- knight respritesby 76561198876704734shows the knight sprites some love commissions open8.1k downloadsupdated 3 y ago
- fake_performance_increaseby Radical Left LunaticIncreases the performance when the frame rate drops by multiplying the speed of all entitys by a frame delta8.1k downloadsupdated 3 y ago
- Neko Hostsby 76561198811060732A new addition to the neko family, the Host family, testing our patience as we wait for them to emerge to shoot us, now cute, more bearable, and if we have got to wait forever, at least they're easier on the eyes. What other monsters would you like to see made into neko versions?8.1k downloadsupdated 21 mo ago
- SKELETONS fucking perish on deathby 76561198390663903Makes ALL skeleton based enemies scream in pain when they die8.1k downloadsupdated 4 y ago
1.6k tweaks mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

