The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth items mods
Everything filed under items by its own author, ordered by how much it is used.
1,309 items mods, most downloaded first · newest update 29 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
1.3k items mods
- Stack Item+(sn)by HyeonJin69 — Chocolate Milk 차지 비율에 따른 공격력 배율 범위를 중첩 개수에 따라 확장합니다. 최소 배율: 30% 40% 50%... 최대 배율: 400% 500% 600%... ---------------------------------------------- 109 — Money = Power 중첩될수록 코인 1개당 증가하는 공격력이 추가로 상승합니다. 추가 데미지: 코인 수 × 0.04 × 개수 예) 1개 = 코인당 +0.04 2개 = 코인당 +0.08 3개 = 코인당 +0.12 4개 = 코인당 +0.16 ......4.7k downloadsupdated 27 d ago
- 502 - Bad Gatewayby 76561198876704734Funnyman modding enterprises is proud to present: 502 - Bad Gateway! This is a secret room item which will open a door to the error room of the floor, after the floor's boss is killed, in a spot that's free and also not red key compatible. If successful, this event is indicated by an obvious soun...4.7k downloadsupdated 4 y ago
- Rock Bombsby KubeRootAdds a single passive item. While holding Rock Bombs, every bomb created by the player will send out a wave of rock explosions in cardinal directions. Now added to the pools! Imitates the stone bombs from Antibirth. Sprites by Xiapher4.7k downloadsupdated 10 y ago
- Goatman 2.0by goatmanNOTICE PLEASE READ: this mod has been tested for both singleplayer and local co-op, however if you intend to play co-op be wary of potential bugs. This mod is a brand new version of my old "Goatman" mod, changing his mechanics and this time adding a tainted version too. Both versions start with b...4.7k downloadsupdated 12 mo ago
- Alan Says Good or Bad Itemsby 76561198423227376When this mod is active a voice line of Alan from Smiling Friends will play once an item is picked up. If the item is of quality 3 or higher Alan will say "Thank God Finally" from S2E3 If the item is of quality 2 or lower Alan will say "What the f*ck?" If the item is blacklisted the normal game s...4.7k downloadsupdated 10 mo ago
- Blood Pactby randooFor when you need more health than lives. What does this mod do? This mod adds a new active item to the game. The active item allows you to "convert" all your extra lives to health. Why "converts"? Converts is quoted because the API doesn't allow you to remove extra lives. This doesn't mean you w...4.6k downloadsupdated 10 y ago
- SacredDreams EID汉化by 76561199253021281SacredDreams的EID汉化模组 汉化作者:B站@青灼QWQ4.6k downloadsupdated 2 y ago
- (OUTDATED DO NOT USE) Another Graphical Overhaulby RareFor years, there have been things that have bothered me about Isaac. It's mostly small stuff, but it's there, and I've finally decided to go out and fix it. Here is the result of my work, as well as the work of many others (all used with permission), combined into one convient mod. -Screenshots a...4.6k downloadsupdated 9 y ago
- Temmie's Head over Tammy's Headby 76561199222029485Replaces Tammy's Head with Temmie from Undertale. This is part of another resprite mod which you can find here:4.6k downloadsupdated 22 mo ago
- Start with Haemolacriaby BarjuhStart each run with Haemolacria Collection with all my Start with mods :4.6k downloadsupdated 4 y ago
- Dragon's Trapby TRPGDragon's Trap is a mod, coded by AstroPenguin642 and sprited by TRPG, which is based off of the game of the same name, where Wonder Boy is cursed by the Dragons and transformed into Lizard-Man, Mouse-Man, Piranha-Man, Lion-Man and Hawk-Man. Dragon's Trap is a passive item that chooses 1 of 5 poss...4.6k downloadsupdated 9 y ago
- DLCby agilebananaDLC More Content... A passive item that spawns extra shop pickups. The further stage you are on, the more pickups that spawn.4.6k downloadsupdated 10 y ago
- isaac's lobotomy (FIRE IN THE HOLE)by 76561199121244854Isaac gets a lobotomy! yippie what it does: - turns brimstone into extreme demon - makes you featured if you have 2 or more brimstones (aka gives yellow glow) - turns tmtrainer into normal face - changes brimstone sfx by overlaying "fire in the hole" - plays "fire in the hole" on pickup - changes...4.6k downloadsupdated 3 y ago
- Swag glassesby 76561198448429576Basically this mod swaps 20/20 sprite with swag mlg glasses very cool4.6k downloadsupdated 4 y ago
- Playable Gello : ReFed!by 76561199090151127This mod adds : 1 new character with it tainted version (you have to unlock it) 14 new items 3 new trinkets 2 new consumables 1 new slot variant Gello Starts with 2 red hearts and 1 black heart Double tapping the fire keys makes gello bite Killing enemies this way will grants a temporary damage u...4.6k downloadsupdated 2 mo ago
- Better Starting Itemsby Lemon MeringuinEdits character starting items to give a stronger start without being too overpowered. Each character has items suited towards their playstyle and backstory. Isaac: Trinket - NO! (Synergizes with D6) Magdalene: Mom's Lipstick, Guardian Angel Cain: PHD (To simulate the playstyle of oldschool Cain)...4.6k downloadsupdated 9 y ago
- Tung Tung Devil replaces Satanby 76561199311872895dont worry hes with tung now TUNG TUNG DEVIL REPLACES SATAN only replaces statue, not boss sorry not sorry maybe if this gets on front page of workshop ill consider it winkwinkwinkwinkwink tung tung god here:4.6k downloadsupdated 7 mo ago
- [REP/+] Quick Start 2.0by NightWareMakes sure your first floor Treasure Room item is atleast of Quality 3 and up. Works with Repentance(+) DLC. Works on Greed(ier) Mode (only 1 Treasure Room will re-roll). Repentogon is not required, but I do recommend using it.4.6k downloadsupdated 14 mo ago
- [AB+ Only] cHUD2.3by ConnorsseurcHUD, or color HUD, is a mod that adds color to many of Isaac's interfaces. Always know what items you picked up, or what it was that killed you! It also introduces a much more informative character select screen, complete with many colors! This mod is only compatible with Afterbirth+. In time I...4.6k downloadsupdated 6 y ago
- Magic Chalkby St. GibonusTarot Cloth for runes. Since Repentance, Tarot cloth does not work with runes. Instead, they made new and unique improvements to the way it works with cards and made it useless with runes. Now runes have no friends :( This mod aims to fix that, by adding Magic Chalk. The chalk Isaac uses to draw...4.6k downloadsupdated 5 y ago
- Button Masherby O_oA 1-room-charge active item found in the Treasure Pool. Spawns a button - that's all. But buttons are a pretty underutilised mechanic.4.6k downloadsupdated 9 y ago
- Sack Items Respriteby 76561198391425301A little mod that resprites sack of pennies, bomb bag, rune bag and mystery bag (the rope only in mystery bag and rune bag). I don't change lucky sack, sack of sacks,... because I play with the sprites of other mods that I like for those items. The mod change the item sprite, and the familiar spr...4.5k downloadsupdated 2 y ago
- Protective Angelby Morc"May the divine be protected..." This brand new quality 4 familiar blocks shots and has a chance to grant the holy mantle effect and shielded tears! Your Protective Angel grows stronger, the more angel deal items you collect! (Key Pieces count as well!) The empowered versions grant the holy mantl...4.5k downloadsupdated 2 y ago
- jevil_scythe_devilsknifeby 76561199226691229Change Death touch to Jevils knife / devilsknife4.5k downloadsupdated 15 mo ago
- Dave (+7 Unlocks) [RGON]by 76561199068958594Meet Dave - The Clone Consumer! Dave is a soul‑heart only character and he spawns 0-2 of his clones upon clearing a room, with a cap of 17. Have your horde fights alongside you, or consume them for a room‑lasting boost in power! Credits chuz: Creator of Dave, mod concept, and sprites natalia_pngi...4.5k downloadsupdated 4 mo ago
- Conception Respritedby HydrantChanges the sprites of Cambion Conception and Immaculate Conception. While Immaculate Conception does not have a counterpart in Four Souls, Cambion Conception does, and since the former is pretty much the opposite of the latter, it made porting it over a lot easier.4.5k downloadsupdated 18 mo ago
- Dogma in Angel Poolby 76561198855158338Adds the Dogma item to the Angel and Greed Angel Room pools, along with adding a unique costume for it. The unique costume can be disabled with Mod Config.4.5k downloadsupdated 5 y ago
- Card Collector - Playable characterby ☢ Nato Potato ☢The Card Collector starts with Card Printer, Deck of Cards, Starter Deck, Ace of Spaces and 20/20, they get a free active item card in the starting room and treasure room each floor and they get 1 active item charge whenever they use up a card. However they won't take any active items aside from...4.5k downloadsupdated 4 y ago
- The Big Cookieby 76561198390663903Introducing the big cookie, an item based off of cookie clicker! Made so i could learn how to code isaac more! This mod adds one active item which every few uses, will give you up to 7 unique cookies*, each with their own effects! (And news tickers!) After all cookie items have been given, it wil...4.5k downloadsupdated 4 y ago
- Vriska Serketby CiiruleanVriska Serket That's right. You know her name, you love her face! :::;) The famed Alternian troll is finally playable in the Binding of Isaac! Extra-canonically, of course. Being a blue-blooded creature, Vriska starts with four soul hearts, and any non-soul hearts are instantly transformed into h...4.5k downloadsupdated 6 y ago
- Bighorn's handby noahmayBighorn's Hand is a new item that constantly drops a troll bomb at a random position in your room. If you find any bugs please report them in the comments and I will fix them as soon as possible. Feedback is appreciated.4.5k downloadsupdated 10 y ago
- Only Ophiuchusby ErflyThe Lost Zodiac Sign. For those who don't want the rest of the constellations. Make sure not to have this enabled if you have the Extra Constellations mod enabled as well On pickup, Isaac will receive a +1.5 damage up (gif is a little outdated), but will be given permanent wiggly tears. Appears i...4.5k downloadsupdated 10 y ago
- Tweaked Torn Photo spriteby ViscerAThis one might be a bit divisive, but I think it looks a lot nicer. Let me know if you disagree! Make sure to leave your feedback in the comments, and don't hesitate to recommend any other sprite tweaks you would like to see from me in the future! For your convenience, I'm uploading every sprite...4.5k downloadsupdated 5 y ago
- Start with Ipecacby BarjuhStart each run with Ipecac Collection with all my Start with mods :4.5k downloadsupdated 3 y ago
- Morphineby AguaMorphine Morphine is a syringe that makes you feel hasty! It amplifies your tear rate, shot speed and movement speed by a large percent! It also lowers your tear delay by a marginal amount! #I♥Syringes Known Issues - Items that directly lower your tear delay will make Morphine's tear delay reduct...4.5k downloadsupdated 10 y ago
- MorePlayingCardsby MerloWelcome to the "More Cards" mod, made by Merlo, Saxarok and Willy052 The whole focus of the mod is, big surprise here, adding more and more cards and variety to the game! From the simple 3 of diamonds, to the wacky UNO cards, this mod has something in store with everyone! Double collectibles, ski...4.5k downloadsupdated 10 y ago
- Lil Krampusby burokContinuing the trend of taking evil monsters and turning them into cute familiars, here's a tiny version of Krampus fighting by your side. Credit goes to Lytebringr for his amazing tutorials.4.5k downloadsupdated 10 y ago
- Superhot and Other Itemsby calster1000This mod adds 3 items to the game. The first is the Super-pepper, which makes everything stop moving as long as your character is not moving, including tears and brimstone lasers. The second is the Z-key, which is an active item which allows you to rewind time in the room, restoring any lost heal...4.5k downloadsupdated 10 y ago
- TikTok Narrator Voice for Itemsby 76561198784125343this mod adds 731 voice lines for items and 189 for trinkets. modded items/trinkets ofc dont have voice lines4.5k downloadsupdated 4 mo ago
- gamer r keyby 76561198869067688Makes R Key modernish4.5k downloadsupdated 3 y ago
- Roodby DrarkyelRood is an passive item found in curse rooms, red chests or dropped by demon beggars. Its main purpose is to reverse devil and angel roles. * Devil rooms offer free items, but can only take one. Angel rooms offer paid items, but can buy all ones. * Devil pacts are now "angel pacts", which forces...4.5k downloadsupdated 8 y ago
- Secret Treasureby bethanw10Repentance Compatible Gives a stat bonus for entering a secret room for the first time (either damage, tears, speed, luck or shot speed). Bonus is about 1.5x more than what Soul Locket gives for soul hearts. Super secret and ultra secret rooms give a double bonus. Picking up the item also reveals...4.5k downloadsupdated 5 y ago
- Toon Linkby VideoGameNewsLink from Legend of Zelda is Created by Shigeru Miyamoto This Mod replace the Isaac with Toon Link. He also come with all is items. Like my addon? Have any problems with it? Feel free to comment.4.4k downloadsupdated 10 y ago
- Extra Birthright Effectsby BrakeDudeThis mod adds alternative Birthright effects for characters as a replacement or supplementary to the original effects. Right now not all characters have extra effects. View birthright additions in our Pastebin! External item descriptions with English, Russian and Spanish languages. Found bugs rep...4.4k downloadsupdated 23 mo ago
- Grotesque Guppyby 76561198448686767This mod resprites Guppy set items and familiars, it also tweaks Dead cat's and Guppy's hairball's familiars' animations slightly. This mod does NOT resprites any character costumes, achievement art and Kid's drawing trinket.4.4k downloadsupdated 14 mo ago
- Spy tf2 replaces backstabberby gunnerright behind you4.4k downloadsupdated 22 mo ago
- Shoop Da Whoop Respriteby mahiopoolIMMA FIRIN' MAH LAZER Replaces the Shoop Da Whoop sprites with more faithful ones. It's recommended to use this mod alongside the "Shoop Da Woop Brimstone Sounds" mod (by demonshayde), in order to achieve the definitive 2007 The Lazer Collection experience.4.4k downloadsupdated 14 mo ago
- Isaac Ukranian 0.2vby DemabelThe Binding of Isaac Українською 1.0 v ВАЖЛИВА ІНФОРМАЦІЯ!! Дана українізація адаптована під англомовну версію гри, перед завантаженням перемкніть на неї, якщо використовуєте іншу. Крім того не забувайте щоб отримувати оновлення, вам треба повністю видалити папку з модом, зайти в гру. Скачати йог...4.4k downloadsupdated 3 y ago
1.3k items mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

