The Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth items mods
Everything filed under items by its own author, ordered by how much it is used.
1,309 items mods, most downloaded first · newest update 29 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
1.3k items mods
- Boomerang but its Gabriel from Ultrakillby 76561198390663903Ever hated the boomerang and thought: "Man I wish it was Gabriel, not his spinning swords, but like actually him." Well then this mod is for you! Using some scuffed coding and MANY voicelines, you can throw your own gabriel at enemies and/or pickups!4.4k downloadsupdated 4 y ago
- alt. Plan C sprite!by ViscerARedesigned sprite for Plan C. Now it's not just Forget Me Now with a red tint :) Make sure to leave your feedback in the comments, and don't hesitate to recommend any other sprite tweaks you would like to see from me in the future! For your convenience, I'm uploading every sprite tweak separately...4.4k downloadsupdated 6 y ago
- Better zodiac signsby 76561199128230206This mod changes the sprites of all zodiac signs! This is my first mod ever, hope you'll like them :D4.4k downloadsupdated 3 y ago
- Start with Damoclesby BarjuhStart each run with Damocles Collection with all my Start with mods :4.4k downloadsupdated 3 y ago
- [REP] Double Soul Heartsby 76561198834414803Double Soul Hearts What's This? As you well know there are many variants of hearts; Red Hearts, Soul Hearts, Eternal Hearts etc. One of them is 'Double Red Heart'. So why don't make a double versions of other variants! And that's it. Update #1 New Double Hearts variant! Double Bone Hearts! Now wh...4.4k downloadsupdated 5 y ago
- just better pedestal spriteby 76561199652076003xoxo mess or 27 idk4.4k downloadsupdated 7 mo ago
- Friendshipby NiroTired of getting bad familiars? With this item they are now useful! This item gives +0.3 damage and +1 range for each familiar in the room. So, abel, bobby, maggy and a lot of useless familiars now become useful. Strong synergy with Box of Friends. If you don't have any familiars, this item gives...4.4k downloadsupdated 4 y ago
- Curse Of Blind To Catby 76561198359088761Changes "?" to this cat.4.4k downloadsupdated 4 y ago
- Start with Technologyby BarjuhStart each run with Technology Collection with all my Start with mods :4.4k downloadsupdated 3 y ago
- [REP] Lifebar - HUD Reskin mod (and more!)by peasPrettify your HUD! This mod reskins various HUD elements to look more visually appealing, taking inspiration from the flash game's unique art style. This mod also reskins select pickups and consumables when dropped on the floor, and whatever else I felt like remaking at the time. Expect updates w...4.4k downloadsupdated 5 y ago
- GoldenKeeperby 76561199091925974Changes everything below - Keeper and Tainted Keeper - Greed and Ultra greed (they share sprites with the characters) - Most of Keeper's costumes - Animations for the Greeds and Keepers - Wooden nickel - Eye of greed - Crooked Penny - Strawman - Keeper's sack - Keeper's kin Any mod that changes t...4.3k downloadsupdated 2 y ago
- wario pill over plan cby Lucy the PirateYou want fun? WARIO show you fun! A simple mod that replaces the sprite for Plan C with a Wario Pill that contains a lethal dose of MDMA! Additionally, using the Wario Pill also comes with its own sound effect!... Sorta. I couldn't figure out if there was a way to add new sound effects, so I had...4.3k downloadsupdated 5 y ago
- Improved Monster Manualby 76561198330371330Funnyman Modding Enterprises is eager to present its newest project, commissioned by MrTea: Improved Monster Manual! This mod features a full, ground-up rework of the item, spawning a unique, permanent familiar based on what room you first activated it in, which you can upgrade with later uses! A...4.3k downloadsupdated 4 y ago
- Item Pickup Soundsby PoondaedalinHowdy! This mod allows the game to play a myriad of custom silly sounds when picking up some items, and the sounds will be either positive or negative based on the item quality. --------------------------- For the record, here's the full list of sounds that can be played: - Positive (Quality 4) M...4.3k downloadsupdated 3 y ago
- Sussy Hearts [OLD]by 76561198845689038A sussy mod where our hearts, animations and an achievement (scared heart) become the characters of among us. Enjoy.4.3k downloadsupdated 3 y ago
- Tweaked Nancy Bombs spriteby ViscerATweaked sprite for Enigm- I mean, Nancy Bombs. Now it's rainbow, to accentuate the item's effect's randomness, and also, because rainbows are fucking awesome. They are just sooo pretty. I love them. Make sure to leave your feedback in the comments, and don't hesitate to recommend any other sprite...4.3k downloadsupdated 5 y ago
- [REP] Incubus Unnerfby MiyukkiWith this mod Incubus again gives player's damage instead of 75%, same as before Repentance You can get this modification in my Repentane Unnerf Pack too4.3k downloadsupdated 5 y ago
- D666by micromarioDescription: Reroll your soul Itempools: Treasure and devil Effects: (Active) If you have red health, the item takes two hearts away and gives you a random devil deal item If you have soul health, the item takes three hearts away and gives you a random devil deal item If you don't have health, th...4.3k downloadsupdated 10 y ago
- [REP] 20/20 Unnerfby MiyukkiRemoves 0.75 damage multiiplier from 20/20, with this mod it works again like before Repentace You can get this modification in my Repentane Unnerf Pack too4.3k downloadsupdated 5 y ago
- [REP+] Always Restockby 76561199164471930Now there is always a restock machine in the shop This mod ensures that you will always find a restock machine in shops, both in normal mode and in Greed Mode. The restock machine is automatically generated in all shops and adapts by adjusting its position when you play as the Tainted Keeper.4.3k downloadsupdated 9 mo ago
- Friend In A Crate (29 familiars in one + 2 challenges!)by 76561198876704734funnyman modding enterprises eagerly presents their newest venture: Friend In A Crate! Friend In A Crate is a familiar item found in shops, crane games and greed mode shops, which spawns a new familiar every room, choosing from a pool of 29 different familiars! All of them are preexisting special...4.2k downloadsupdated 4 y ago
- Oxygen Not Includedby Aks ♐Combining the worlds of The binding of Isaac and Oxygen not included, This mod introduces a new character, the Duplicant, and other nifty items coming from the oxygen not included universe! Current features~ ~~~~~~~~~~~~~~~ New character: Duplicant Damage: -1 Speed: -0.3 HP: 3 ~~~~~~~~~~~~~~~ New...4.2k downloadsupdated 10 y ago
- MajorasMaskModby GiurassicEver wanted to feel protected ? Ever wanted to feel powerful ? Well now you can ! The ALL NEW Majoras Mask will give you everything you need (if all you need is a +5 damage up and 2 black hearts) Soon to come : Different tears ANIMATIONS MORE items Suggestions are welcomed :D4.2k downloadsupdated 10 y ago
- Rei Chiquita Mr. Dollyby 76561198825922892Changes Mr. Dolly into a Rei Ayanami plush (or fumo) from Neon Genesis Evangelion4.2k downloadsupdated 4 y ago
- Greed Room Items - Repentanceby ThirstyPengnHere is the updated mod which includes bonus rooms rather than changing the start room and the greed mode items will no longer crash the game: Items added to the Greed shop and treasure rooms.4.2k downloadsupdated 4 y ago
- Mystery Gift (BOOSTER PACK #1)by StripedUPDATE: This mod was released officially as a part of March 2017's booster pack! No need to download anymore, but will leave this mod page up regardless. A fun little gift box active item just in time to be late for Christmas! When opened, spawns a random item from the current room's item pool! B...4.2k downloadsupdated 10 y ago
- Start with Knife piece 1by BarjuhStart each run with Knife piece 1 Collection with all my Start with mods :4.2k downloadsupdated 3 y ago
- Mr Dolly to Ralseiby Sakura ♡Changes Mr. Dolly to look like Ralsei from Deltarune. For Sink.4.2k downloadsupdated 22 mo ago
- ADHDby The Australian King Of ArrowsA simple little mod pack that gives you a new item and a new pill: Items: * ADHD - Get a massive speed boost, however you get a constant slight shaking to your character. Can't stop, won't stop. Pills: Ritalin - Give's you a small speed boost. However if you have picked up ADHD, then this pill gi...4.2k downloadsupdated 10 y ago
- Monstrance Respriteby BaicherraThis mod change the "Monstrance" item sprite.4.2k downloadsupdated 5 y ago
- Decent Startby 76561199481423011There will spawn 1 coin 1 bomb 1 key 1 wooden chest in the starting room. 初始房间会生成1硬币,1炸弹,1钥匙和1木箱子。4.2k downloadsupdated 20 mo ago
- Terraria teksturaby AsukaМод меняет предметы Айзека на предметы террарии The mod changes Isaac's items to terraria items The mod changes 176 items Over 56 familiars Over 240 costumes (from over 50 different items) 6 transformations Keys, bombs, coins All hearts 15 trinket Redrawn all tarot cards and inverted tarot cards...4.2k downloadsupdated 3 y ago
- Roaring Knight's Swordby 76561198438625509Changes the Spirit Sword to Roaring Knight's Sword\the Black Knife from Deltarune. Features unique projectiles,charging animations and SFX from the game for the spin attack4.2k downloadsupdated 16 mo ago
- Items Reforged [Afterbirth+]by KaliItems Reforged! This mod aims to rebalance and tweak items that would otherwise be detrimental to a run, while remaining faithful to the vanilla experience. Supports External Item Descriptions! Supports Mod Config Menu! Supports Revelations! Supports Fiend Folio! & More! All changes are configura...4.2k downloadsupdated 6 y ago
- Social Anxietyby Exudias*Passive item *You feel endangered! (You gain damage proportionate to the amount of enemies in the room you are in) This is my first passive item I've added to the game. Awesome people: Lytebringr, Eufuu and CustomPhase See it in action here:4.2k downloadsupdated 10 y ago
- Vinesauce Joel One Dollarby 76561199004129025Adds a one dollar pickup sound to "A Dollar" that's it4.2k downloadsupdated 3 y ago
- Mrs.Bubblesby XiapherMrs. Bubbles is a fish that flops around the room, occasionally creating damaging water-creep pools, which hurt enemies. This item will spawn the dead fish in every room. The trinket will have a chance of adding Mrs.bubbles to the room for that room. She might be there on the next room, Might not...4.2k downloadsupdated 10 y ago
- Spray Paintby ☢ Nato Potato ☢This item inspired by Jet Set Radio allows you to 'tag' the walls of certain rooms with graffiti, each completed graffiti tag in the room boosts your DPS. When you have the item most rooms will have spots against the walls where you can paint, by interacting with these spots (SHIFT/CTRL/swap) you...4.1k downloadsupdated 2 y ago
- Lil' Blastocystby XalumFollowing my pattern of boss-based familiars I introduce Lil' Blastocyst. This orbital will slowly break down as it's hit, disappearing over time. Breaking down into a maximum of four separate orbitals. At the start of each new floor the orbitals will regenerate into the largest size and can be b...4.1k downloadsupdated 9 y ago
- Syringes! A New Consumable [Afterbirth+ Only]by AgentCuccoA brand new type of consumable! - Syringes behave similar to pills, they give temporary buffs or debuffs to the players, and they are undiscovered until used for the first time. - At the beginning of a run, a pool of 13 random syringes is determined for the rest of the run. - Syringes have a 33%...4.1k downloadsupdated 6 y ago
- Smooth Drugsby Warhamm2000Resprites syringes to smoothies, enjoy your cup of euthanasia!4.1k downloadsupdated 4 y ago
- Dogma Clickerby Phno 🐙"Having trouble with your TV? Just switch the bloody channel. Easy as that :v" It should be completely normal and logical that you can defeat an enemy, which comes out of the tv, instantly if you just turn off the tv. Right? Right. So, now this is possible with the clicker. The clicker remains it...4.1k downloadsupdated 3 y ago
- Box Cutterby nickBOX CUTTER Let your soul escape Type: Active Cooldown: None Effect: Take one red heart damage and spawn a half soul heart. Pools: Shop, Secret, Curse An activated item, Box Cutter has no cooldown. Instead, it uses your life as a resource. Every time you activate Box Cutter, it will deal you a red...4.1k downloadsupdated 10 y ago
- Zodiac Items Into Constellations Respriteby 76561198452145624It looks like no one has done this before. I hope these sprites are distinguishable enough and I hope it's not too much of an abomination of a resprite, cause I've tried my best. Have fun with it! Colored version of this resprite:4.1k downloadsupdated 10 mo ago
- Red Keyby 闼昂Red Key on start.4.1k downloadsupdated 3 y ago
- A Dance of Fire and Isaac!by PoondaedalinHappy April Fools' Day! I made a rhythm game in Isaac! As per usual, the content of this mod can be accessed by going into the Custom Challenges, and finding the challenge named "PD - A Dance of Fire and Isaac!". The mod includes 5 tracks (which may increase in the future, but I make no promises)...4.1k downloadsupdated 19 mo ago
- Dr. House Over PHDby 76561199231191134This mod changes the sprite for the items PHD - Dr. House False PHD - Evil Dr. House note: if you dont like Evil Dr. House just deleting him from the mods files via picture should remove him4.1k downloadsupdated 16 mo ago
- Don Quixote Limbus Company as Death Card and Necronomiconby 76561198381080953Changes the Necronomicon and Death Card (and also Black Hearts) sound effect into Don Quixote from Limbus Company screaming "Limbus Company". This truly was our Limbus Company (the antibirth music mod i used in the video -4.1k downloadsupdated 2 y ago
1.3k items mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.

