Mods / Sound EffectsThe Binding of Isaac: Rebirth mods
The Binding of Isaac: Rebirth sound effects mods
Everything filed under sound effects by its own author, ordered by how much it is used.
740 sound effects mods, most downloaded first · newest update 29 Oct 2026
AllGraphics1.9kLua1.9kTweaks1.6kItems1.3kSound Effects740Player Characters709Active Items621Bosses475Familiars442Pickups405Music403Enemies359Rooms347Trinkets336Cards248Challenges198Floors169pills155Hazards145Removals143Shaders136babies112
740 sound effects mods
- Neco-Ark coinsby 76561198833945718This mod is created for all true connoisseurs of Neco ark The mod changes all the usual models and coin picking sounds to the screams of Neco ark and her head This mod will appeal to everyone who likes to play in conjunction with other modifications related to this topic, for example, Isaac's rep...6.1k downloadsupdated 2 y ago
- Chargin' Targe instead of Marsby 76561198825922892Changes Mars to be 200% more scottish6.1k downloadsupdated 5 y ago
- Grand Dad for Little Hornby LolkatReplaces Little Horn with the Vinesauce meme Grand Dad. Replaces the boss itself, boss ui (Name and portrait), and sound effects with Grand Dad and Joel's voice.6.1k downloadsupdated 10 y ago
- Loud Ni#ra Over Larynxby 76561198345921126Simple mod that replaces the Larynx scream with Loud Ni#ra. I cant make videos for this kind of stuff since my computer cant handle it, but Im sure you can imagine what it sounds like.6.0k downloadsupdated 5 y ago
- golden freddy jumpscare for death screenby 76561199087673261changes death screen to golden freddy fazbear, happy halloween bitches6.0k downloadsupdated 3 y ago
- Cleo-Cobraby 76561198353126873This mod REQUIRES StageAPI and Revelations to function. -Description- All hail the queen of the tomb. The sinister slither Cleo-Cobra rises. awaken from her slumber, Cleo's ready to feast on any who dare approach her tomb. and it looks like Isaac's her first course for the century. Can he survive...6.0k downloadsupdated 8 mo ago
- Tainted Lilith Whipcrack SFX Replacementby ❤ pavizi ❤I wanted to do this the moment I saw this character. Shoutout to my friend Vita for the help.6.0k downloadsupdated 6 y ago
- Cursed Voiceoversby SprSnpr_I edited some voiceover lines to make them . . . cursed All voiceovers have been changed-- outside of cutscenes, naturally All new voiceovers were made using preexisting ones6.0k downloadsupdated 5 y ago
- Soul of the Keeper replaced with "here comes the money"by M!stwalkaChanges Soul of the Keeper activation sound to something "more fitting". Credits to WWE and Naughty by Nature for the awesome Shane O'Mac theme tune. edits file ⧵resources-dlc3⧵sfx⧵voiceover⧵soul of the keeper.wav6.0k downloadsupdated 5 y ago
- Markiplier Greed Deathby 76561199127032644Replaces the death statue and death scream of Ultra Greed with Golden Markiplier.6.0k downloadsupdated 3 y ago
- Mario 1-1 In Isaac!by 『Sora』Adds Mario's first ever platforming adventure level to Isaac! This isn't a rom, it's Mario recreated using the base Isaac engine and physics. You can jump, shoot tears, bounce on enemies, collect mushrooms, and everything in between. Implemented as a separate character named Mario that you play as.6.0k downloadsupdated 5 y ago
- MGE loading screensby 76561198419052590Changes floor transition to mge furry crying meme(but with Isaac). Music for transition is untouched because it would also affect boss intro sounds. Also modifies loading screen transitions(the one after you pick a character), now it has tick tock joji sound and a bunch of mge brothers thumbnails...5.9k downloadsupdated 6 mo ago
- Tourettes Guy Hurt Soundsby krameraadChanges Isaac's hurt and death sounds to something the player might relate to more.5.9k downloadsupdated 5 y ago
- Cool! Katskins Resprite Collection!by 76561198995475535This is a giant resprite pack I put together mostly for personal use, handpicking the best resprites from practically every pack on and off the workshop into one compilation for faster loading times and compatibility. VERY FEW THINGS INCLUDED ARE MADE BY ME, credit to the respective authors are i...5.9k downloadsupdated 22 mo ago
- Gamblecore Wheel of Fortuneby 76561199068993168Wheel of Fortune and Reversed voice lines are replaced with gamblecore's "Let's go gambling", and getting a fly payout (and to an extent getting bad pills) plays "Aw dang it" Disclaimer: This mod does NOT include SFX for winning payouts, go to this person's mod instead (6/22/2024) Thanks for 2K d...5.9k downloadsupdated 2 y ago
- Dr. Zomboss!by knuxchuxReplaces Mom with Dr. Zomboss, the Brainiac Maniac from the Plants vs. Zombies series. Also affects Mausoleum Mom. Original PvZ graphics by Rich Werner, and edited by me.5.9k downloadsupdated 4 y ago
- *Snore* mimimimi deathby 76561198354546959*snore* mimiiimiimimiii, isaac is just taking a long nap5.9k downloadsupdated 4 y ago
- Wonder Flowersby sublimnlYou're all soggy! Imagine a wonderful world, where the flowers talk to you like you're an Italian plumber. Imagine them criticizing your every move, every choice, and your mere existence. Well, imagine no longer! Wonder Flowers have found their way in to your basement - and boy do they have a lot...5.9k downloadsupdated 3 y ago
- CHAINSAW MANby 76561199155657668this mod changes berserk to chainsaw man and little chubby to pochita5.9k downloadsupdated 4 y ago
- Darkest Dungeon's Ancestor Narratorby ExeOmniaLet our Ancestor tell us the horrors we will face down in the dark. A new shivering voice to celebrate our tears down, bad trips and all others wonders of cards, pills and runes that we will be led to discover in the dark caves and tenebrous dungeons of the basement. Watch your steps, and remind...5.9k downloadsupdated 8 y ago
- Mario & Luigi Soundtrackby moldy_train2Works with Repentance! Make sure you have the Repentance version of Music Mod Callback before using. Replaces all music and jingles possible with the Soundtrack Menu mod by ☢ Nato Potato ☢. Music used is from the first three games in the series, and the specific game is listed next to each track...5.9k downloadsupdated 5 y ago
- [AB+] Hush is now Garfieldby Concept Art Noelle HolidayThis mod turns the Hush into our favorite monday hating and lasagna loving cat! Garfield also threatens to kick Odie off the table when shooting tear lasers. Respriting by waterPsychiatrist (me bby). Expect an update before the year is over... hehehe5.8k downloadsupdated 7 y ago
- Brother may i have some oats over Ascentby 76561199219910159Changes the voicelines from the Ascent to whatever this Pigs are Thanks to burialgoods for this masterpiece5.8k downloadsupdated 17 mo ago
- Taco Bell Damage Soundby 76561198376887343Replaces Isaac's hurt sound with the Taco Bell bong.5.8k downloadsupdated 6 y ago
- Persona 3 Reload Soundtrackby 76561199013793134My attempt at a Persona 3 Reload Soundtrack mod. I have checked every track and made intro's and cuts to make them cleanly loop (as best as I could, a couple might be slightly jank). Requires soundtrack menu + music mod callback + mod config menu (or equivalents), and has full jukebox support (hi...5.8k downloadsupdated 6 mo ago
- The Serpent (+24 Unlocks)by Kerkel2 New Characters Have Appeared in the Basement! The Serpent aims to spice up the normal Isaac formula by making the player choose between 1 of 3 unique Blessings and 1 of 3 unique Sins upon starting a run. Blessings grant a modest benefit to help you along, and Sins provide a strong negative effe...5.8k downloadsupdated 3 mo ago
- 【中文配音】以撒的结合开场动画 (Intro Chinese Mandarin Dubbing)by OliverberryFrom Bilibili Uploader 上火龙肝 Uploader link: Video link: ========Tips======== You may need to turn off all mods related to the Intro before activated. ========Credit======== Mod @Oliverberry Voice @尚尚5.8k downloadsupdated 22 mo ago
- sus black powderby sex haverReplace pentagram with amogus. Randomly plays an amogus sound effect when pentagram drawn5.8k downloadsupdated 3 y ago
- The Binding Of Nikoby 76561198925841301Explore new perspectives with Niko's mod! THIS MOD ONLY WORKS WITH REPENTANCE/REPENTANCE+!! The Binding of Niko brings the character of Niko from the video game Oneshot into a new world. The sun is a new active that makes Niko strong enough to defeat enemies. Featuring: 1 New character EID compab...5.8k downloadsupdated 9 mo ago
- Kingdom Hearts Soundtrackby deyskilSoundtrack from the Action JRPG game, Kingdom Hearts. REQUIRES SOUNDTRACK MENU MOD OR POTATO PACK 2 Early version of a Soundtrack Menu Kingdom Hearts Mod. There may be problems with playback, looping, etc., so let me know if you find any and I'll try to fix it soon. Enjoy! Track List: Floors Base...5.7k downloadsupdated 6 y ago
- Madness Combat Musicby 76561198369844905Somewhere in Nevada... Changes 60+ in-game songs to OST from Madness Combat, Madness Project Nexus Classic and MADNESS: Project Nexus Highly recommend to checkout Krivaan Madness mods they are awesome! | Leave noticed bugs in the comments | Menu - Madness Project Nexus: Theme Song Levels: Basemen...5.7k downloadsupdated 4 y ago
- JoJo Pillar men themeby YusufReplaces the mega satan theme with the pillar men theme aswell as the death sound with Shiiizzzaaaa5.7k downloadsupdated 7 y ago
- Oguri Cap Judas Reskinby 76561199766476788Turns Judas into Oguri Cap from Umamusume Pretty Derby and Cinderella Gray. Includes many other theme variations: - Book of Belial turns into Tamamo Cross Plush; - The transformation induced by Tamamo Cross Plush and Devil Card turns the character into Oguri Cap's menacing shadow form from the an...5.7k downloadsupdated 6 mo ago
- Hit The Jackpotby MiemGPlays this legendary masterpiece of a song when you see a quality 4 item5.7k downloadsupdated 7 mo ago
- Hell's Kitchen Boss Introby GazasterReplaces the boss intro jingle with the funny dramatic Hell's Kitchen noise.5.7k downloadsupdated 5 y ago
- SHUT UP Purgatoryby 허농이5.7k downloadsupdated 22 mo ago
- [REP/REP+]Glacier's Laboratoryby Red.16Just some random, wacky, and maybe unique stuff I make from time to time. Currently, the mod has: -4 characters -100+ items -20+ trinkets -13 pocket items -4 pills -Some new rooms Feel free to try it and leave a comment!5.7k downloadsupdated 9 d ago
- Gapers/Zombies talk about the Salami Lidby 76561198838552783replaces Zombie Walker Kid noises with salami lid5.6k downloadsupdated 5 y ago
- MVmod 2by SpychopatInspiré du MVmod, mais en mieux ! Des tas de nouveaux sons pour mieux entendre Mister MV rager ou s'extasier sur un Cricket's Head. Notez que le mode est maintenant plus intelligent ! Au lieu de simplement remplacer les fichiers sonores, on entend maintenant MV grace à un script incroyable ! Grâc...5.6k downloadsupdated 4 y ago
- Donkey Kong Country Soundtrackby moldy_train2UPDATE: Now includes music from DKC1 as well as DKC2! Also rearranged some existing songs. Updated for Repentance! Make sure to have the Repentance version of Music Mod Callback before using. Now works with the Jukebox mod! To see all tracks, including Repentance ones, subscribe to TeSLaSP2's ver...5.6k downloadsupdated 5 y ago
- Tainted Samson sfx replaces with Mellstroyby 76561199261304124Replaces every berserk mode sound with Melstroy voice/Заменяет звуки из берсерка на "Я уже красный,культурно не получиться","Бэм бэм бэм","БЫСТРЕЕ".5.6k downloadsupdated 13 mo ago
- CatCoinsByTimby 76561198798896586Coin resprite You like Isaac, money and cats? Then this Mod was made for you! ❗️❗️❗️(Donation machine resprites will not work with mods like Animated machines)❗️❗️❗️ Mod resprites: -Coins -Donation machines -Trinkets Wip: -Items5.6k downloadsupdated 23 mo ago
- Weird Route Jingle Over Freeze SFXby CammyCatReplaces the sound effect that plays when an enemy is frozen with the weird route jingle.5.6k downloadsupdated 4 mo ago
- The Isaac of Isaac: Reisaac+ (Episaac)by SyncerReisaac epilogue cutscene by Syncer I made this for my fan who asked me to showcase Reisaac mod5.6k downloadsupdated 9 y ago
- tf2 soldier "box" sound effect when picking up boxby 76561198842992121Box! -Soldier from Team Fortress 2 It is simple. Just plays 'Box!" sound from tf2 soldier.5.6k downloadsupdated 3 y ago
- LTG replaces arguing parentsby 76561198369844905Replaces ascent voice lines (path to Beast) with Low Tier God inspirational speech :) KnowYourMeme Your life is nothing! You serve zero purpose! You should k*** yourself now! And give somebody else a piece of that oxygen and ozone layer, that's covered up so we can breathe inside this blue trappe...5.5k downloadsupdated 5 y ago
- Wind Waker Explosion and Sound (Pixelated)by SpongePierreAn explosion in the style of The Legend of Zelda Wind Waker, but most specifically based on the ones in Four Swords, and pixelated to fit Isaac's style Also replaces the sound effect with the one from the games Original version here: Known Issues -Huge and Small explosions will look weird and I h...5.5k downloadsupdated 5 y ago
- TF2 for Ultra Harbingers + The Beast!by StaccatoI was one of the many people who subscribed to the original mod that gave Ultra War the voice of Soldier, from Team Fortress 2 (and was later updated for all the Harbingers). Recently, while fighting the Harbingers, I noticed the voicelines were no longer there. The original mod has seemingly dis...5.5k downloadsupdated 5 y ago
740 sound effects mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.