Mods / Bosses

• AAntibirth Rotgutby KyleAdds back the Rotgut textures and animations from Antibirth.11.9k downloadsupdated 20 mo ago
• Ddelirium drops r keyby gan_regenas per a request on reddit. for those of you who wanna get completion marks easier but in a more spicy way. 💖 (pretty much just an alternative to the every floor mod.) definitely works in repentance, should work in ab+, dunno why it wouldnt. edit: r key isnt in ab+ to begin with oh my god lol11.9k downloadsupdated 5 y ago
• Mmother is a gorillaby 76561198835190493transforms mother into a large gorilla. this mod is simply bananas!!!!!! - changes mother sfx, fight music, portrait, and sprites - monky spin - may add gorilla chase sequence(??)11.9k downloadsupdated 3 y ago
• RRag Mega Respriteby 76561199063654767Another mod that I did not create, but that I upload because the creator asked me. This mod is a resprite of Rag Mega. The creator is Scroto McBolas and he says: "the best mod ever, a super duper hyper cool experience, the mod that changes lives and is super original, this mod inspired aladar and...11.9k downloadsupdated 5 y ago
• JJr. Fetus Bossby DeadInfinityA new boss mod for The Binding of Isaac Afterbirth+, adding Jr. Fetus, a new Caves boss. He has a 15% chance to replace the normal Caves boss, and uses missiles as his primary means of destroying Isaac! This mod was developed by OrigamiDragon (art + animation) Krowski_nall (art) and Meowlala / De...11.9k downloadsupdated 9 y ago
• TThe Binding of Steve (Rep. version) : Minecraft Crossoverby Ly FechaIf you like my work, please consider clicking on the like, favorite or even reward button. THIS IS THE REPENTANCE VERSION. Afterbirth+ version : Warning : Due to game and api instability, sounds and some items have been removed temporarly. They will probably be added back after some Repentance up...11.8k downloadsupdated 4 y ago
• MMore Devil Deals (+Angel Deals)by StlkngneThis mod enables Devil Deals (+Angel Deals) to show up in more stages: Basement I (early deal) Pre-Ascent (Dad's Note) Ascent (backwards path) Corpse II / Mortis II (Mother) ??? (Hush) Sheol / Cathedral (Satan / Isaac) Dark Room / Chest (The Lamb / ???) The Void (Delirium) Home (The Beast) Ultra...11.7k downloadsupdated 2 mo ago
• RRepentance Boss Champions CONTINUEDby kittenchillyThis mod requires REPENTOGON to work! The original mod now ported to REPENTOGON for bug fixes and better mod compatibility! Perhaps even more in the future...? This mod adds 36 new champion variants to the many bosses added in Repentance. These champions seek to emulate the vanilla game - keeping...11.5k downloadsupdated 20 mo ago
• MMega Susby LeifybearCRAZED Streamer Jeremy Albertson KILLS CHILD with bare hands. ------------------------------------------------------------------------------------------------------ Changes Mega Satan to Mega Sus, a horrific amalgamation of Jerma and the ancient demon only known to mortals as amogus. -Comes with...11.4k downloadsupdated 5 y ago
• NNeon Genesis Evangelion Soundtrack (Music Overhaul)by 76561198396299582Music, Jingles and MORE from the critically appraised 𝚴𝐞𝐨𝐧 𝐆𝐞𝐧𝐞𝐬𝐢𝐬 𝐄𝐯𝐚𝐧𝐠𝐞𝐥𝐢𝐨𝐧 franchise! Check out the "Death & Rebirth" Collection for even more Neon Genesis Evangelion Mods! Soundtrack Overhaul Video Showcase - "Youtube Video" Version Without Bonuses - "Soundtrack Only Ver." This is (not) an or...11.4k downloadsupdated 4 mo ago
• PPyrocynical Megafattyby Hazardous BaconPyro when isaac11.2k downloadsupdated 5 y ago
• SSinge is BALLIN'! (Rep+)by knuxchuxI always thought Singe's boss portrait looked like he was doing a slam dunk, so I made this mod in response to my warped, unsalvageable mind. Singe now wears a sweatband and sweat shorts, and his spike balls are now basketballs. He's prepped and ready for the NBA! UPDATED to now support Repentanc...11.2k downloadsupdated 23 mo ago
• AAngel Drop Items Remakeby RudyA remake of the original Angel Drop Items mod, with new features, bug fixes, rebalance and support in the current game version. Were you ever annoyed that after getting both key pieces fighting both Uriel and Gabriel was entirely pointless? Have you never gotten lucky to get the Filigree Feather...11.1k downloadsupdated 10 d ago
• Ssalvationby XtrikeThe Binding of Isaac: Salvation Salvation or Repented characters is a mod that aims to be an alternative of the tainted characters but instead of getting more broken they become more innocent. So far we have 1/17 Characters Completed, being Azazel For each character there is atleast 9 unlocks as...11.1k downloadsupdated 2 y ago
• TTenna Deltarune over Lambby 76561198335424411Cosmetic mod that changes the Lamb to Tenna from Deltarune. Also changes the Lamb's fight music to "It's TV Time!" I tried to keep the sprites and animations in line with the original Lamb's spritesheet (hence why Tenna is so short here hehe), so there shouldn't be any trouble with hitboxes and t...11.0k downloadsupdated 17 mo ago
• ((AB+) Genesis+ Revivedby BroskiPlays on ROG Ally1.2 BUGFIXES + 1 NEW ITEM ----- Fixed Trapdoor appearing in Catacombs / Caves Fixed Rune not able to be picked up Fixed Boss Room related Bugs Fixed all stuff related to Catacombs Disabled Stagesapi Added 1 new Item: Too Much Water! Enjoy the update and be sure to send me any bug reports :) GENES...10.8k downloadsupdated 9 y ago
• [[Rep] The Binding of Isaac: Benevolenceby OliveRiderThe Binding of Isaac: Benevolence Features: - 2 Characters - 60+ Items - 6 Trinkets - 400+ Rooms - 2 Monsters - Monster and boss tweaks - Item tweaks Planned features: - 2 MORE characters - 40+ MORE items - 15+ MORE trinkets - 1200+ MORE rooms - MORE enemies and bosses - More alt floors - MORE it...10.8k downloadsupdated 15 d ago
• RRock angelby 76561199037324892Rock moment it was a very stupid idea10.7k downloadsupdated 5 y ago
• BBig Horn But He is Meby shishiAlright guys, Big Horn couldn't make it today- doctor's appointment, I think. He never told me. Either way, I got called in to fill his shoes. Don't think you can slack off just because he has a substitute, though! I ain't letting you leave this boss room until you're done.10.6k downloadsupdated 5 y ago
• EEnvy but betterby 76561199075010917Envy trollface Yuh10.6k downloadsupdated 3 y ago
• TTETO BEGGARby 76561199172310537This mod replaces the devil beggar and hellgame sprites with kasase teto!1!10.5k downloadsupdated 12 mo ago
• DDark Matter Bossby GuilhermeA new boss appears, now from Kirby universe, you can find it as the boss in the Gehenna floor or a little rarely in common rooms in the Dark Room and Chest floor UPDATE: there's a modpack containing all of my bosses now, check it here: It has it's own music from the original game (you can disable...10.5k downloadsupdated 3 y ago
• ((Rep+)Hard mode major bosses patternsby DotThis is Repentance+ version of the mod, AB+ version is here : This mod adds new patterns and phases of major bosses in hard mode. Also involves some pattern enhancements and resprites. In addition, new patterns, phases and shields can be enabled or disabled in Dead Sea Scrolls menu. This mod is s...10.4k downloadsupdated 5 mo ago
• AAbortionbirth+by NarilliaEverybody knows and loves Abortionbirth, but we know it doesn't quite "fit in". To appease those who need their game to mesh together in a fun and coherent way, we hereby present... ABORTIONBIRTH+! The total conversion overhaul mod for Afterbirth+ that brings the DLC up to the quality we expect f...10.4k downloadsupdated 9 y ago
• AAlwaysMegaSatanby Coco Poops®spawn key pieces after isaac, satan , lamb and ???/ blue baby10.4k downloadsupdated 6 y ago
• GGuillotina Replaces Mega Fatty!!by 76561199233031397boom shakalaka simple mod, reskins mega fatty to be guillotina from that one fuckin game mewgenics,, made by uhhhhhh... i forgot who made it fuckk replaces champion variants or whatever theyre called doesnt replace the other mega fatty sorry10.4k downloadsupdated 10 mo ago
• Nnice mom legby 765611988516383981.更改妈腿为红色高跟、黑丝高跟、白丝高跟、裸足 2.女祭司和铲子生成的妈腿改为黑丝高跟 3.图片由AI生成并使用Aseprite手动修改10.4k downloadsupdated 2 mo ago
• PPeep is Pepe the Frogby imKeimPeep is replaced with Pepe the Frog!10.3k downloadsupdated 10 y ago
• SSpamton Sfx For Satanby HululuChanges Satan and Mega Satan's sound effects (that aren't already in the spamton instead of satan mod) to sounds from Deltarune (also affects things that use the same sounds) (the spamton satan reskin is made by Ridler)10.3k downloadsupdated 5 y ago
• EEveryone is Isaacby RidlerISAAC AND HIS ISAAC... Everyone Is Isaac! A resprite mod that changes nearly every enemy and boss into Isaac! Creating the Best Isaac and his Isaac experience you can get! This is a long awaited update to the worst attempt at The Binding of Isaac ReIsaac mod ever. This mod changes: - a lot of ene...10.2k downloadsupdated 19 mo ago
• Uultra death bad to the boneby daliadds the riff from bad to the bone to ultra deaths skull attack10.2k downloadsupdated 4 y ago
• TThe Binding of the Spireby 76561198355620741This is Chinese version. English version were published 杀戮尖塔MOD 34个新道具 34个新卡牌 全新的玩法 --游戏玩法： WSAD移动 鼠标左键攻击敌人 鼠标右键使用卡牌/点击按钮/选择卡牌 键盘1/2/3/4/5/6快捷键使用卡牌 如果发现任何BUG私信或者在评论里指出 4/28更新： 怪物自带准心了 关掉请控制台输入"target" 自带开启debug 7 关掉请控制台输入"debug7"10.2k downloadsupdated 8 y ago
• NNikocado Megacadoby The MorrowAds the big guy to the game.10.2k downloadsupdated 5 y ago
• GGutso the Greatby blorAfter being finished nearly 2 years ago, Gutso the Great has finally appeared in the Depths! (and also Necropolis and Dank Depths but not as commonly) Requires Custom Stage API I remain, BlorengeRhymes P.S. Thank you fiendfolio people for testing and balancing :)10.1k downloadsupdated 5 y ago
• DDouble Trouble+by Пардон{-------------------------------------} X2-Money X2-Hearts X2-Bomb X2-Boss and monsters 2x Mom's Heart 2x items Black market 2x Isaac 2x Hush 2x Mini Boss 2x Delirium⊙﹏⊙ Good luck!10.0k downloadsupdated 9 y ago
• ((AB+ Only) Customizable Game Over Screenby TaigaTreantNOTE: As of Repentance v1.7.7, game over support has become official. This mod is no longer necessary, as a result, and will create issues if enabled. Thank you for your support. Customizable Game Over Screen is a mod intended to expand the capabilities of modders in editing the game over screen....9.9k downloadsupdated 6 y ago
• JJevil Bossby GuilhermeA new boss arrives, this time from Deltarune here's: Jevil UPDATE: there's a modpack containing all of my bosses now, check it here: It can be found in Mausoleum It has it's own music from the original game (you can disable it if you don't want with the Mod Config Menu Pure) Stage Api is required...9.9k downloadsupdated 3 y ago
• UUltra Conquest (Old)by 76561198855158338THIS IS THE OLD VERSION OF THIS MOD! Go download the new version!9.9k downloadsupdated 4 y ago
• CCHUD replaces CHADby 76561199142178350Replaces Chad with everyones favorite chuddy.9.9k downloadsupdated 9 mo ago
• Ccool ANGEL STATUE modelby 76561199192206099This mod changes the angel's model :39.9k downloadsupdated 4 mo ago
• ⸱⸱ᴗ⸱ Monstroby GoosetávoeMonstro reskin. ⸱ᴗ⸱9.8k downloadsupdated 3 y ago
• MMin-Min Respriteby DarianChanges Min-Min's sprite to look similar to her cut and early concept, Maid in the Mist Changes all the graphics associated with Min-Min's boss sprite, as well as the Vs. screen graphic Should be compatible with Enhanced Boss Bars:9.8k downloadsupdated 4 y ago
• RRooms Galore! Fiendish Editionby 76561198325454024Rooms Galore! Fiendish Edition is an expansion to the Fiend Folio Reheated mod that adds up to 2500+ new rooms! And much like Rooms Galore, Fiendish Edition also comes equipped with a more interesting void floor!9.8k downloadsupdated 4 y ago
• DDOOM in Isaac!by PoondaedalinWarning: This mod may not be suitable for people who are sensitive to flashing lights or effects! If you want to play the first level with mouse look/firing, click here! (note: just the first level) "Can it run DOOM?" "Yes, yes it can." "...sort of." This mod contains a few levels of a DOOM/Wolfe...9.8k downloadsupdated 14 mo ago
• TThe Duke of flies but he's omni manby 76561198811411536this mod changes the duke of flies and lil blub sprites to omni man9.6k downloadsupdated 3 y ago
• CCute Duke of Fliesby eweThis mod changes the sprites of the Duke of Flies to look more cute rather than terrifying. It affects it's default form as well as it's champion variants (orange and green). It also changes it's portrait during the VS screen. This mod will override or will be overriden by any mod that changes th...9.6k downloadsupdated 21 mo ago
• DDelkisserUwUby 76561199661094703(English): This mod was inspired by this other mod: I seriously can't believe the effort I put into making Delirium Boykisser. Boykisser is love, Boykisser is life. (Español): Este mod fué inspirado por este otro mod: (Es el mismo link que el de arriba, no lo voy a pegar dos veces) En serio no pu...9.5k downloadsupdated 4 mo ago
• Tthe destroyer over angelsby 76561199724434256this mod replaces angel statue and all angels sprites (expect Delirium's forms) to The Destroyer and his champion version from Mewgenics :steamhappy: also this mod changes the Angel Room music to Angel Wings (instrumental) by Ridiculon view my workshop for more mods with Mewgenics my channel: aut...9.5k downloadsupdated 18 d ago

475 bosses mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.