Mods / Bosses

• GGenesis+ Septic Shock!by budjmtSomething smells funny beneath the Caves... After over 2 years, let's go to the Septic! - Septic is back and in the best shape of its life! It's been ported to the newer StageAPI for greatly enhanced stability and performance. - To access the floor, go to Ch 2 and look for a greenish rock. - The...9.4k downloadsupdated 7 y ago
• FFair Co-op Items (Online)by ArtuurIMPORTANT REQUIREMENT To use this mod in online multiplayer, it is strictly required to have Isaac Online Modded installed. MOD CONFIGURATION & DESYNC WARNING To customize this mod's settings, you need to install Mod Config Menu - Impure. CRITICAL ONLINE INSTRUCTIONS: ALL players in the lobby MUS...9.3k downloadsupdated 28 d ago
• MMalware & Spam - The forgotten Modern Horseman of the Apocalypse [RGON]by DüpsyThe forgotten Modern Horseman has appeared in the Basement! The forgotten Modern Horseman of the Apocalypse Malware and his trusty steed Spam have appeared in the Basement, flooding your screen with malicious software, intrusive ads, and endless spam. Like a virus burrowing into the heart of our...9.3k downloadsupdated 20 mo ago
• TThe Beast into Mr. Beastby robbRAP. BATTLE. ISAAC VS. MR BEAST BEGIN Changes the sprites and music into Mr. Beast from the Squid Game vs. Mr. Beast rap battle... but you can scrap the s cause he never missed a beat Credits: trashei - graphic changes kuba - music changes9.2k downloadsupdated 4 y ago
• EEiballs' Hush Respriteby the loathsome gamermy very first mod includes brand spankin new sprites for: hush boss portrait both phases of hush blue gapers blue conjoined fatties blue boils hush flies hushy enjoy check out my other resprite mod here:9.1k downloadsupdated 4 y ago
• UUnique Music for Cameo Bossesby Clove G.This mod adds unique music for the cameo bosses that appear in other games Edmund McMillen made, using music from the games they originated from. Tracklist: Vs Boss: C.H.A.D. - C.H.A.D.'s Lullaby | Super Meat Boy Steven - Time F cuk SIHT | The Basement Collection Gish - Versus Music | Gish Sister...9.1k downloadsupdated 1 mo ago
• PPatrick Gluttonyby SchlomannChanges Gluttony into Patrick star :)9.0k downloadsupdated 9 mo ago
• GGhost Pepper Rework!by Mr. HeadcrabThe beloved Ghost Pepper is looking hotter than ever! This all new Ghost Pepper shoots out the same white flame you can find in Downpour, one that will exorcise any monster in it's way! These disembodied souls are far weaker than the hosts they come from, and will prioritize getting back into the...9.0k downloadsupdated 3 y ago
• MMegaFemmyby 76561198967539132Replaces Mega fatty with Mega femmy9.0k downloadsupdated 5 y ago
• Tthe binding of maggy's toy box and WOB isaac's secret stashby 76561199032451894BUG FIX: 超级撒旦和鲍勃的烂头动画修复！ MegaSatan and Bobsrottenhead Animation fix! 炸弹乞丐被炸不出炸弹修复！ Fixed the Bomb Bum not dropping an insta-exploding bomb when blown up！ 究极傲慢宝宝瞎几把乱闪修复！ Fixed the Ultra Pride Baby incorrect flashing animation! 个人整合包，非原作者，模组来源： maggy's toy box maggy's toy box reborn WOB isaac's sec...8.9k downloadsupdated 11 d ago
• DDOGMA ECHOby Loud & NoisyThis mod simply replaces Dogma's Boss theme, "Living in the Light", with "ECHO" by Crusher-P. Just like the original battle theme, Phase 1 will play an instrumental version of the song, and phase 2 will add in the lyrics. Artwork provided by: Yazawa Akio(Tweaked by me) Music by: Crusher-P8.9k downloadsupdated 4 y ago
• TThe Binding of Isaac: Eternal Youthby snooch"The Binding of Isaac : Eternal Youth" Is planned to be a huge content pack for the game! This is a mod made from a small bunch of people who share similar passion for the game. Current Content ============== 10 Items Abomination Baby - A familar that likes to reward you with a troll bomb at the...8.9k downloadsupdated 10 y ago
• RRooms and Roams (700+ rooms)by MarbleTearsHello, welcome to Rooms & Roams!! an expansive mod for more adventures This mod add Adds: 100+ rooms for every chapter (basement, caves and depths) 50 + rooms for every alts (burning basement, cellar, etc) 50 + rooms for every alt2 chapter (downpour, mines, etc) + 200 special rooms (planetariums,...8.9k downloadsupdated 14 mo ago
• EEXPLODING PLUM (100% Chance)by 76561199087673261restores the 100% chance of baby plum exploding to death FUCK BABY PLUM!!!!!!!!!!!!!!!!!!!!!!118.7k downloadsupdated 4 y ago
• TThe Cursed and Brokenhearted - "I Never Forgot You"by 76561198813288416Notice I will not update this any further, I just readded it so people can play it Prerequisites for the best experience StageAPI - For the new bosses and such MMC - For the new music in the game! MinimapAPI Immortal Hearts from Team Compliance - For easier new personality unlock! EID - descripti...8.6k downloadsupdated 3 y ago
• TTrollirium (Troll Face Delirium)by Squizzle DizzleThis mod replaces Delirium with the Troll Face Based on8.5k downloadsupdated 10 mo ago
• [[Ab+ Only] Complete Eternal Edition+by GuilhermeTHIS MOD IS OUTDATED, Click Here FOR THE REPENTANCE VERSION This mod adds a new champion variant for almost all monsters and for all bosses, all based on the classic game. Eternal enemies are tougher and haves new mechanics, with a small chance of dropping a reward. ATTENTION • Incompatible with:...8.5k downloadsupdated 4 y ago
• TThicc Siren (Re-Upload)by 76561199229505861I am uploading this mod because the original creator яйца пришли made it a troll for some reason. Flowey face in the picture is from this mod: if you want to spawn her on debug console type: spawn 904.08.5k downloadsupdated 2 y ago
• YYo Mama's Shadowby HazicaReplaces Mother's Shadow with that Brody guy from Yo Mama, complete with new sounds and chase theme. Made as a joke for a friend group but I figured I'd upload it. Intro will be longer than usual so don't use the mod if you're speedrunning, or something. note: im not updating the video, so its ou...8.4k downloadsupdated 5 y ago
• WWho's That Isaac Boss ?by 76561198375403876Transform the boss reveal screen into a guessing game with the Who's That Isaac Boss mod! Inspired by the Who's That Pokémon segments in the TV show. Can you guess who you're gonna fight? This mod should be compatible with custom bosses.8.4k downloadsupdated 5 y ago
• BBetter Boss Barby SpyroBoss bar now has numerical data showing what % of the health you have done. Also some swords and spooky red eyes!8.4k downloadsupdated 10 y ago
• DDemogurglingsby TheErrorMakes your gurglings do AAAAAAAAAAAAAAAAAAAAAAAAAAAA Also thanks to Goganidze for helping with script And AidenGamez for idea8.3k downloadsupdated 4 y ago
• FFaith's Rewardby DaGammlaDo you have a bad Computer? Do the fireworks produce lag? Just press "F1" and you're save! CAUTION ! This mod is possibly not compatible with others but Works perfectly with True Co-op Content : --Dynamic Boss drops-- Bosses have a chance to spawn Boss specific items like Mask of Infamy -> Isaac'...8.3k downloadsupdated 8 y ago
• AAlt Path + Mother in Greed Mode!by 76561199034036813With the 1 year anniversary of Planetariums in Greed Mode coming up, I knew I had to return to my roots and make another greed mode mod. So, I present to you: The Alt Path in Greed Mode! Yes, I know this has been done before (twice in fact) but the original mod had 3 main problems that this mod f...8.3k downloadsupdated 4 y ago
• Sshuodedaoliby 76561198845833421Monstro replacement with Shuodedaoli8.2k downloadsupdated 3 y ago
• CClassic Boss Rushby EstrogenGirlMega Man style Boss Rush is here! This mod adds a new challenge to the game called "Classic Boss Rush" that allows you to fight all of the bosses in the entire game from Monstro to Delirium. Also, you get an item after each one. Made by AstroPenguin6428.2k downloadsupdated 9 y ago
• BBetter Lasers For Fallen Angelsby Guilhermethis mod changes the color of the laser spawned by fallen angels to red.8.2k downloadsupdated 4 y ago
• YYAPO (Yet Another Portrait Overhaul)by FerrySimple enough I wanted to redo some boss portraits, I went for something cute for the cute bosses while I went for some more detail for the not as cute bosses, some exceptions here and there and they might be subject to change in the future. Check em' at the images, there's 24 now! More to come i...8.1k downloadsupdated 4 y ago
• FFat Teto Beastby 76561199549838612The Beast is now Kasane Teto, and the Horsemen of the Apocalypse are now Miku, Gumi, Neru, and Luka! P.S. The Horsemen of the Apocalypse have only been redesigned from the moment you see them; in the future, there will be a complete rework of the bosses themselves. There are also plans to add spe...8.1k downloadsupdated 11 mo ago
• MMixed Boss Collection Part 1by GuilhermeThis mod is a pack of all my boss mods, does to limitations of how many values a mod can save then It doesn't contain all the bosses, CLICK HERE for the part 2 of the mod and HERE for the part 3 of the mod it also features it's own menu config to change which bosses do you want and which ones wit...8.1k downloadsupdated 3 mo ago
• TThe Binding of Brazil (AB+)by TCDubs✎ 𝗥𝗲𝗽𝗲𝗻𝘁𝗮𝗻𝗰𝗲: --------------- A Tradução Brasileira de "The Binding of Isaac: Afterbirth +" ~Todos os Itens e Suas Próprias Descrições ~Pílulas, Cartas, Runas e Suas Descrições ~Alguns Nomes de Bosses ~Os Desafios ~O Bestiário ~Interface ~Todas as Conquistas ~Booster Pack 1,2,3,4 e 5 ~Andares ~ S...8.0k downloadsupdated 8 y ago
• BBrainrot Edition!by 76561199844292366Those who know..💀7.9k downloadsupdated 18 mo ago
• Ppudzian bumbinoby 76561198334935970POLSKA GUROM7.8k downloadsupdated 4 y ago
• TThe Librarian [Ab+/REP]by AgentCuccoThis mod has been tested on rep to work fine, but it might be a bit unstable. Additions This mod adds a new boss to the game: The Librarian. This boss has a 25% chance of appearing in libraries (similar to Greed). The boss possesses two different phases, however the second phase is exclusive to H...7.8k downloadsupdated 6 y ago
• Fflash angelsby 76561198339469043mod that makes angels look much better if you played flash isaac 80 years ago7.8k downloadsupdated 5 mo ago
• DDark One and Adversary Have Glowing Eyes!by GuwahavelMakes Dark One's and Adversary's eyes glow in the dark.7.8k downloadsupdated 5 y ago
• HHonk Brosby Mr. Metal AlexWhat's a good crying child game without some good old coulrophobia? So that's what I'm fixing with this: -Big Horn is now Big Honk! Straight out of the circus! -Little Horn is now... Little Horn. Cute, and now also hilarious! -Loki is now Lolki! along his other version Lolkii! Each half with thei...7.7k downloadsupdated 5 y ago
• Ddeath with troll faceby 76561198453270934death with troll face cool mod7.7k downloadsupdated 4 y ago
• BBoss Resprite - Rainmakerby FerpeResprited and tweaked the animations of the gayest boss in Repentance. Honestly this is the only rep boss that kinda needed a glow-up from Antibirth and didn't get one. Doesn't have champion nor Delirium versions in the base game so this is all you get. He's now like 14.5% gayer.7.7k downloadsupdated 4 y ago
• CCobson (Beast resprite)by 76561198338773226HWABAG Bone chilling, spine tingling, genre redefining, slow-burn resprite mod that will change The Beast with Cobson. no 'p embedded.7.7k downloadsupdated 3 y ago
• Mmy dog as mega satanby 76561199056952875mega satan but he is replaced by my dog, max. this took me like two hours to make lmfao hope you enojoy7.6k downloadsupdated 3 y ago
• MMega Satan but It's My Dad (The Sequel)by unfunny username #1967The long awaited sequel is finally here, i finished my exams with a passing grade and now have nothing better to do than make stupid bullshit like this, i hope you enjoy playing because i sure enjoyed making. <3 Shoutout to my dad for his unwavering patience and cooperation and thanks to all you...7.6k downloadsupdated 4 y ago
• Bbossroulette_V2by 허농이✅ This mod was created by the livestreamer Isaac Oh Heon-Young. ✅ Purpose: A content-focused mod designed for veteran players who have achieved Dead God. ✅ How to use: Press the I key to randomly select a boss. ✅ Notes: If the boss route is set to Delirium, the Hush door will open regardless of t...7.6k downloadsupdated 10 mo ago
• NNecrocyst Bossby GuilhermeBlastocyst went to corpse and rotted with the rest of the floor, now you can find it at the boss room of the corpse I. unlike the other bosses that I made, this one don't drop any item because this boss is not from another game or a reference to another game Custom Stage API is required to make t...7.6k downloadsupdated 3 y ago
• NNeko Repentance Bosses!by transgirlcathyUh oh! Everything is cats! ...At least all the Repentance bosses are! How did this happen?! This mod changes all bosses added in Repentance to have cat ears. It also gives cat ears to big horn. This effects Vs. screens, in game sprites, and a few extra hidden easter eggs for you to find! Leave a...7.5k downloadsupdated 5 y ago
• BBest Isaac Musicby 76561199030889749Isaac has a lot of pretty good music of various composers, why not extract the best of the most of them??? Like other the music mods, this one replaces almost all Afterbirth/Repentance music tracks for others than I think are better, there are some compositions of DannyB (Flash Isaac), Mudeth (An...7.4k downloadsupdated 3 y ago
• NNotYourSag's Siren w/ Red Hair [REUPLOAD]by EMORYGives Siren the appearnace that NotYOurSagittarius draws her in, but with red hair. Comfy sweater. Red hot red-head. Original creator deleted the red-hair variant. Art by NY_Sagittarius7.4k downloadsupdated 4 y ago
• SSatan in Devil Rooms (+Fallen Angels)by StlkngneThis mod was inspired by Devil Statues Plus and Bombable Devil Statue. There's a devil statue in each Devil Room. Now, sometimes it'll turn into a Satan fight. Once you defeat Satan, each devil deal item will cost a single point of damage rather than one or more heart containers. Note: After you...7.4k downloadsupdated 11 mo ago

475 bosses mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.