Mods / Bosses

• NNeko Colostomiaby transgirlcathyYou knew this was coming. Credit to The Binding Of Isaac discord for telling me to do this. Also credit to my girlfriend for telling me to make the poop bombs have ears. I didn't do that but it was a good idea.7.4k downloadsupdated 5 y ago
• SShe Got An Educationby OctotronChanges the Siren to have some nice glasses and a suit because she got an education. Isn't that pleasant?7.4k downloadsupdated 5 y ago
• WWhiteNight Dogmaby 76561198365949909Changes Dogma to WhiteNight Aleph Abnormality from games Lobotomy Corporation and Library of Ruina Features: - WhiteNight as Dogma - New music - New sound effects - Styled visual effects of second phase 🔑🌙 Project Moon7.4k downloadsupdated 7 mo ago
• AAbortionbirth Revelations Compatibilityby NarilliaIf you're one of the lunatics who plays Revelations's Glacier, but wish you could still play the far superior Northern Glacier from Abortionbirth, this is the mod for you! Patches a compatibility issue in Abortionbirth Pack 2: The Heckoning, to allow playing inferior mods alongside it. Also adds...7.4k downloadsupdated 9 y ago
• BBlastocyst is King Slimeby Ivan_CrysisBlastocist now is King Slime . . . just that . . .7.3k downloadsupdated 5 y ago
• BBoss Resprite - Dingle + Dangleby FerpeShitpost moment Resprited and reanimated a shitty boss amirite poopy shitty farty haha caca poopoo brrrap Complete with its 3 champion variants + their Delirium versions! (I know Dangle isn't a champion but it might as well be one come on)7.3k downloadsupdated 4 y ago
• BBaby Plum doesn't dieby Richard MoelleuxMakes it so when you deplete Baby Plum's health, it just plays its leave animation instead of the death animation (yes that's it). No more heartbreak :(7.3k downloadsupdated 5 y ago
• SSteve over Hornfelby 765611990681377477.3k downloadsupdated 11 mo ago
• BBiblically Accurate Angelsby Hatless(MOD WAS MADE FOR AFTERBIRTH+) Angels in the Bible are apparently described as disturbing masses of flames and eyes, which I thought would be neat in a game like Isaac. This mod changes: - The Angel Statue Sprite. - Uriel's Sprite. - Gabriel's Sprite. - Delirium Uriel's Sprite - Delirium Gabriel'...7.2k downloadsupdated 6 y ago
• BBoss Resprite - Daddy Longlegs + Triachnidby FerpeResprited and reanimated both Daddy Longlegs and Triachnid. The attack where they stomp a lot drove me nuts because the animation didn't convey them being unreachable by Isaac's tears, so I did the logical thing of redoing everything. Complete with their own Delirium variants! This is now include...7.2k downloadsupdated 4 y ago
• BBygone Over ???by FissionMetroid101"The end is nigh!" It always bothered me how ??? was always just a reskin of Isaac, even if he plays differently... Buuuutttt seeing as Bygone is technically also blue baby, I thought it'd make a perfect visual replacement! This mod features NO gameplay changes, but it does include a slight visua...7.2k downloadsupdated 5 y ago
• DDeep laboratories (AFTERBIRTH PLUS VERSION)by Mogumi-------------------------------------------------------------------------- DEEP LABORATORIES FOR REPENTANCE IS OUT! -------------------------------------------------------------------------- IMPORTANT! Don't force this mod in Repentace! the new DLC changed a lot of sprites and how things work in...7.2k downloadsupdated 6 y ago
• BBoss Rush Plus - More Varied Boss Wavesby Clove G.Everything is Terrible! More Foes have Entered the Boss Rush! Boss Rush Plus is a mod that updates the Boss Rush to include the Afterbirth+ bosses and all the Chapter 4 Bosses that were missing. Alongside Mini-Bosses such as the Sins, their Super Variants, and Krampus. As well as the Repentance B...7.2k downloadsupdated 4 y ago
• IImproved Animation for Satanby GuilhermeThis mod improves the animation of satan while he is attacking in phase two. His wings will not be closed while attacking anymore, now he is always flying7.2k downloadsupdated 4 y ago
• SSalem | The Soul Seekerby AgentCuccoSalem Approaches. The trials have begun, and the bells of awakening toll. The Soul Seeker rises once more, to take by force what was thought lost. Heed thy warning, for you will die, to outrun her is a foolish man's fight. Speed's the key, the bells ought not toll, for if they do, the Witch shall...7.1k downloadsupdated 18 mo ago
• LLuncheon (Tapeworm boss)by MsGummyLuncheon is a new boss inspired from the mechanics of Tapeworm, a board game by Edmund McMillen! Rather than directly attacking the player, Luncheon will throw up his insides which are swarming with wriggling tapeworms, who each attack differently depending on their segments. (Requires StageAPI)...7.1k downloadsupdated 6 y ago
• HHOMERO song for every bossby cringecoreadds better song over every boss fight HO ME RO HO ME RO HO ME RO7.1k downloadsupdated 9 mo ago
• CCaco Plumby График ЗапоевThis mod replaces visual of boss Baby Plum to the visual of Cacodemon sprites from Doom 2. Animations also fully work. ✦✦ Please don't forget to push the like button and leave comment! ✦✦ If you want to Caco Plum to get massive explosion when he dies (g-fuel), you want to take this! You also may...7.1k downloadsupdated 4 y ago
• BBetter Fallen Angelsby *{~kamenshchik~}*A simple mod that alters appearance of the fallen angels that can be seen at mega satan boss fight. Now they look more demonic. Also, feel free to change this mod as you want. Contact me if you discovered bugs.7.0k downloadsupdated 2 y ago
• FFamily Guy Death Pose for the lambby BarneyReplaces The Lamb's body sprite with the family guy death pose. Works for both The Lamb and his Delirium form. Will probably be incompatible with other Lamb resprites, hit me up if it breaks your mod and I'll gladly try to fix it. Thanks for getting this to the popular section, I hate all of you7.0k downloadsupdated 4 y ago
• RRoad Roller!by lesserStar-Changes Monstro into a road roller from jojo -So monstro's tooth becomes a Road roller item -the name of the item is not chenged (idk how to do that) Sprite is from Jump Ultimate Stars6.9k downloadsupdated 8 y ago
• CCave Angler bossby Mr SexNew boss for flooded caves, thanks to All-Seeing for help with the sprite, and numerous people on the Modding of Isaac discord server for help with code6.9k downloadsupdated 4 y ago
• WWhatsApp Whistle for Dingleby EthanChanges Dingle's whistle to the whatsapp notification6.9k downloadsupdated 3 y ago
• SScooby Doo Creepy Run replaces Chased By Deathby 76561199035670843This mod replaces Chased By Death with the theme song from Scooby Doo Creepy Run!!!! I saw a bunch of Tiktok comments asking for this and a bunch of videos editing it into the game so I decided to make it into an actual mod lmfao :P (THIS IS ONE OF TWO MODS I'VE MADE ABOUT SCOOBY DOO CREEPY RUN!!...6.9k downloadsupdated 5 mo ago
• TThe Grinding of Isaac: Meme Hellby XXL Pizzaytp sexer ruins isaac's life Replaces almost every sound effect and song in the game with meme trash and YTP humor. Features custom graphics occasionally. BEFORE PLAYING: Other mods that change player animations and sounds may cause compatibility issues. For the intended experience I reccommend d...6.8k downloadsupdated 4 y ago
• DDogma Fidget Spinner Attackby smemmoChanges the spinning attack of Dogma to a fidget spinner.6.8k downloadsupdated 5 y ago
• BBrindle.by 76561198977878686Includes: brindle note: brindle is owned by zephyr!!!6.8k downloadsupdated 4 y ago
• RRe: Item Chests Before Motherby StlkngneDoesn't this already exist? Yes This mod requires REPENTOGON. It uses a newer Repentogon API that properly supports Guppy's Eye. The room before Mother will contain 4 golden chests with treasure room items inside. If you have The Left Hand trinket then you'll get devil room items instead, and hav...6.8k downloadsupdated 11 mo ago
• GGreedier Bosses (OUTDATED)by slapjakThis mod is outdated! You can subscribe to the new, expanded version here Greedier Bosses is a cosmetic mod that will include Greed-themed reskins for all bosses that appear in Greed mode. Reskins only appear in Greed mode by default, however that can be changed via Mod Config Menu . Using Mod Co...6.7k downloadsupdated 5 y ago
• Rreap creep respriteby 76561198876704734this mod polishes reap creep's sprites a lil to be more up to snuff in comparison with the other repentance bosses commissions still open! hit us up!6.7k downloadsupdated 4 y ago
• LLittle horn vampireby ThingKingTMGives little horn a halloween costume.6.7k downloadsupdated 4 y ago
• [[Uma musume Pretty Derby] Oguri Cap as Beastby 76561199290715406Simple replacement MOD The material comes from tanukimaker No uma musume has been hurt in this mod.Feel free to use it If you have good suggestions, you can leave a message to share.6.6k downloadsupdated 22 mo ago
• Llebron sunshine over dogma versus screenby 76561199121244854this mod does things (doesn't change Dogma itself) you are my sunshine my only sunshine6.5k downloadsupdated 3 y ago
• TTennistulaby SprSnpr_A mod that makes the Mother fight just a little bit less unbearable... Changes: - The sprite of the Corpse version of Fistula Doesn't Change: - The normal fistula sprite - The melee swing sound effect (only in the video)6.5k downloadsupdated 4 y ago
• BBEAST TWEAKSby DeadInfinityHas the final fight in home gotten a little too repetitive for you? If so, then BEAST TWEAKS might be the mod for you! Randomized horsemen and changes to the structure of the final fight with The Beast herself inject newfound variety directly into your game! Features Randomized horseman order! Fa...6.4k downloadsupdated 4 y ago
• GGodmode汉化模组by 76561199253021281⚠️该模组已过期，请在我的合集里下载新的EID汉化模组⚠️ 这是一个对Godmode Achieved模组的EID进行了汉化的模组 请确认你已安装了Godmode Achieved和EID 汉化作者：B站@青灼QWQ 感谢B站@长山小春0213 提供的汉化帮助6.4k downloadsupdated 2 y ago
• DDeath Wishby ☢ Nato Potato ☢The Death Wish active item allows you to challenge extra bosses and earn extra items. When used you are teleported to a new boss room separate from the one with the exit trapdoor, the boss you fight is totally random, but does not include bosses which are marked on the completion note like satan...6.4k downloadsupdated 9 mo ago
• TThe Peepingby Jean-Alphonse6.4k downloadsupdated 10 y ago
• [[OUTDATED] BLOAT EXPLODES ON DEATH!by Hideo KojimaBLOAT FINALLY FUCKING EXPLODES ON DEATH!!!!!!!!!!!!!! (just like baby blum) A mod for our beloved community r/fuckbloat Credits to Goncholito for making this mod possible (checkout his baby plum fucking dies on death too!!!) IT TOOK ME 3 HOURS TO MAKE THIS MOD :((((6.4k downloadsupdated 4 y ago
• !! Coming Down: Stomps, Fixed![REUPLOAD]by TidloasHey, you can find the rework of this mod here : Unlike the "Rework" version, this mod is strictly the same as the original, With the amn2 and the incompatibilities that go with it, with the simple difference that delirium stomp is fixed. Coming Down: Stomps adds high-visibility visual tells to al...6.3k downloadsupdated 4 y ago
• Ddogma unused attacksby 76561199017158324Did you know that there are unused attacks for Dogma in the gamefiles because they would be "too difficult"? I thought its a bit sad they werent really in the game, so I looked for mods that implement them, and searched the workshop but i couldnt find any... so i ended up trying it myself :D Chan...6.3k downloadsupdated 8 mo ago
• FFaster Boss Deathsby DevSimple mod, bosses no longer take eons to die. All bosses, including modded ones now die 30 times faster (configurable)6.3k downloadsupdated 3 mo ago
• WWHERE IS OMNI MANby 76561198838990189WHERE IS HE Replaces the mom fight with the immortal (and others)6.3k downloadsupdated 19 mo ago
• BBoss Resprite - Mask of Infamy + The Visageby FerpeResprited and reanimated a glorified enemy located in Necropolis for no good reason. I really hope they update this boss so that it's an actual boss and not whatever this is. Complete with its champion and Delirium variants! If you don't like the reference to its concept art version I put a norma...6.1k downloadsupdated 4 y ago
• GGrand Dad for Little Hornby LolkatReplaces Little Horn with the Vinesauce meme Grand Dad. Replaces the boss itself, boss ui (Name and portrait), and sound effects with Grand Dad and Joel's voice.6.1k downloadsupdated 10 y ago
• FFaith Dogma Reskinby 76561198973457670replaces the dogma boss graphics with purist the spectres faith the unholy trinity reskin of it faith crucifix mod: faith music mod:6.1k downloadsupdated 3 y ago
• TTBoI: Radbirth [NUCLEAR THRONE]by majoThe Binding of Isaac: Radbirth is a mod that was made for Afterbirth in 2016 by majofps and EthanTheLion. Over the past week, it has been ported over and updated for the new DLC, Afterbirth+! Radbirth's Features: - ALL NEW Nuclear Throne characters - ALL NEW Challenges - Nuclear Throne themed ite...6.1k downloadsupdated 10 y ago
• CCleo-Cobraby 76561198353126873This mod REQUIRES StageAPI and Revelations to function. -Description- All hail the queen of the tomb. The sinister slither Cleo-Cobra rises. awaken from her slumber, Cleo's ready to feast on any who dare approach her tomb. and it looks like Isaac's her first course for the century. Can he survive...6.0k downloadsupdated 8 mo ago

475 bosses mods, most downloaded first. Each one has its own page here with what it needs to run and where its author publishes it; the files themselves stay with the author and are never re-hosted on this site.